Kinase PIM1 promotes prostate cancer cell growth via c-Myc-RPS7-driven ribosomal stress

Zhang, Chang-wen; Qie, Yunkai; Yang, Tiehong; Wang, Li; Du, Eugenie; Liu, Yan; Xu, Yong; Qiao, Baomin

doi:10.1093/carcin/bgz030

Cited by 16 publications

(6 citation statements)

References 38 publications

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“…Studies indicate that the serine/threonine protein kinase pim 1 is known to be an oncogene and is present in the cytoplasm and nucleus and is capable of phosphorylating different targets, most of which are involved in the cell cycle and apoptosis processes . Pim1 is overexpressed in various tumours such as breast cancer and prostate cancer and promotes tumour progression by promoting cell proliferation, survival and inhibition of apoptosis . Moreover, Pim1 promotes cancer cells growth by enhancing the Warburg effect and promotes epithelial‐mesenchymal transition and oncogenesis .…”

Section: Discussionmentioning

confidence: 99%

miR24‐2 accelerates progression of liver cancer cells by activating Pim1 through tri‐methylation of Histone H3 on the ninth lysine

Yang

Song

Meng

et al. 2020

J Cellular Molecular Medi

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Several microRNAs are associated with carcinogenesis and tumour progression. Herein, our observations suggest both miR24‐2 and Pim1 are up‐regulated in human liver cancers, and miR24‐2 accelerates growth of liver cancer cells in vitro and in vivo. Mechanistically, miR24‐2 increases the expression of N6‐adenosine‐methyltransferase METTL3 and thereafter promotes the expression of miR6079 via RNA methylation modification. Furthermore, miR6079 targets JMJD2A and then increased the tri‐methylation of histone H3 on the ninth lysine (H3K9me3). Therefore, miR24‐2 inhibits JMJD2A by increasing miR6079 and then increases H3K9me3. Strikingly, miR24‐2 increases the expression of Pim1 dependent on H3K9me3 and METTL3. Notably, our findings suggest that miR24‐2 alters several related genes (pHistone H3, SUZ12, SUV39H1, Nanog, MEKK4, pTyr) and accelerates progression of liver cancer cells through Pim1 activation. In particular, Pim1 is required for the oncogenic action of miR24‐2 in liver cancer. This study elucidates a novel mechanism for miR24‐2 in liver cancer and suggests that miR24‐2 may be used as novel therapeutic targets of liver cancer.

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Section: Discussionmentioning

confidence: 99%

miR24‐2 accelerates progression of liver cancer cells by activating Pim1 through tri‐methylation of Histone H3 on the ninth lysine

Yang

Song

Meng

et al. 2020

J Cellular Molecular Medi

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“…The functional biology and related molecular mechanisms of small ribosomal proteins have been widely investigated (21). The mRNA expression level of RPS7 was found to be highly expressed in prostate cancer compared with that in adjacent normal tissues, and a high mRNA expression level of was also found to be positively associated with poor outcome via promoting cell proliferation (22). RPSA was revealed to activate AKT-related pathways and to promote pancreatic cancer cell metastasis (23).…”

Section: Discussionmentioning

confidence: 99%

Identification of 40S ribosomal protein S8 as a novel biomarker for alcohol‑associated hepatocellular carcinoma using weighted gene co‑expression network analysis

Sun²,

Lei³

et al. 2020

Oncol Rep

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Alcohol-associated hepatocellular carcinoma (HCC) is a subtype of HCC with poor prognosis. The present study aimed to identify key biomarkers for alcohol-associated HCC. The gene data profiles and corresponding clinical traits of patients with alcohol-associated HCC were downloaded from The Cancer Genome Atlas (TCGA) database. Firstly, good genes and good samples were identified, which were subsequently used to conduct weighted gene co-expression network analysis (WGCNA). Hub genes in the significant modules were selected following Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses, and from constructing a protein-protein interaction (PPI) network. Real hub genes among hub genes were determined following progression, survival analysis and gene set enrichment analysis (GSEA), as well as reverse transcription-quantitative PCR and immunohistochemical staining of non-alcohol-and alcohol-associated HCC samples. In total, 64 good samples of alcohol-associated HCC with height score <160 were selected, from which 15,195 good genes were identified and used to conduct WGCNA; 8 gene co-expressed modules were identified using WGCNA, while 3 modules (including pink, magenta and turquoise) were significantly associated with Child-Pugh score, T-stage and body weight. Following GO and KEGG analysis and construction of the PPI network, a total of 30 hub genes were identified in the aforementioned 3 gene co-expressed modules, while 16 hub genes (including AURKB,

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“…153 Additionally, the aberrant ribosomal biosynthesis of PIM1 and ribosomal small subunit protein 7 leads to ribosomal stress, thereby promoting tumor progression within prostate cancer. 154 Dysregulation of translation factors, such as eIF5A, eEF1, and eIF4E, contributes to enhanced protein synthesis and upregulation of factors involved in cell proliferation, invasion, and metastasis in pancreatic cancer. [155][156][157][158][159] Methylation of tRNA by the RNA methyltransferase METTL8 plays an important role in the protein translation process of pancreatic cancer.…”

Section: Cancersmentioning

confidence: 99%

Protein translation: biological processes and therapeutic strategies for human diseases

Jia,

He,

Huang

et al. 2024

Sig Transduct Target Ther

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Protein translation is a tightly regulated cellular process that is essential for gene expression and protein synthesis. The deregulation of this process is increasingly recognized as a critical factor in the pathogenesis of various human diseases. In this review, we discuss how deregulated translation can lead to aberrant protein synthesis, altered cellular functions, and disease progression. We explore the key mechanisms contributing to the deregulation of protein translation, including functional alterations in translation factors, tRNA, mRNA, and ribosome function. Deregulated translation leads to abnormal protein expression, disrupted cellular signaling, and perturbed cellular functions- all of which contribute to disease pathogenesis. The development of ribosome profiling techniques along with mass spectrometry-based proteomics, mRNA sequencing and single-cell approaches have opened new avenues for detecting diseases related to translation errors. Importantly, we highlight recent advances in therapies targeting translation-related disorders and their potential applications in neurodegenerative diseases, cancer, infectious diseases, and cardiovascular diseases. Moreover, the growing interest lies in targeted therapies aimed at restoring precise control over translation in diseased cells is discussed. In conclusion, this comprehensive review underscores the critical role of protein translation in disease and its potential as a therapeutic target. Advancements in understanding the molecular mechanisms of protein translation deregulation, coupled with the development of targeted therapies, offer promising avenues for improving disease outcomes in various human diseases. Additionally, it will unlock doors to the possibility of precision medicine by offering personalized therapies and a deeper understanding of the molecular underpinnings of diseases in the future.

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Kinase PIM1 promotes prostate cancer cell growth via c-Myc-RPS7-driven ribosomal stress

Cited by 16 publications

References 38 publications

miR24‐2 accelerates progression of liver cancer cells by activating Pim1 through tri‐methylation of Histone H3 on the ninth lysine

miR24‐2 accelerates progression of liver cancer cells by activating Pim1 through tri‐methylation of Histone H3 on the ninth lysine

Identification of 40S ribosomal protein S8 as a novel biomarker for alcohol‑associated hepatocellular carcinoma using weighted gene co‑expression network analysis

Protein translation: biological processes and therapeutic strategies for human diseases

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