Kin Recognition and the Major Histocompatibility Complex: An Integrative Review

Brown, Jerram L.; Eklund, Amy

doi:10.1086/285612

Cited by 239 publications

(170 citation statements)

References 112 publications

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“…It is highly genetically variable and appears to affect mate-choice decisions in mice (Egid & Brown 1989;Potts et al 1991) and humans (Ober et al 1997; but see Hedrick & Black 1997). MHC variation in natural populations, and its effect on behaviour, remain understudied (see reviews in Alberts & Ober 1993;Brown & Eklund 1994;Penn & Potts 1999). …”

Section: Discussionmentioning

confidence: 99%

Wild female baboons bias their social behaviour towards paternal half-sisters

Smith

Alberts

Altmann

2003

Proc. R. Soc. Lond. B

115

102

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Adult female cercopithecines have long been known to bias their social behaviour towards close maternal kin. However, much less is understood about the behaviour of paternal kin, especially in wild populations. Here, we show that wild adult female baboons bias their affiliative behaviour towards their adult paternal half-sisters in the same manner and to the same extent that they bias their behaviour towards adult maternal half-sisters. Females appear to rely heavily on social familiarity as a means of biasing their behaviour towards paternal half-sisters, but may use phenotype matching as well.

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Section: Discussionmentioning

confidence: 99%

Wild female baboons bias their social behaviour towards paternal half-sisters

Smith

Alberts

Altmann

2003

Proc. R. Soc. Lond. B

115

102

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“…The second major paradigm for how MHC diversity can be maintained at high levels in natural populations invokes MHC-dependent sexual selection (Brown and Eklund, 1994;Jordan and Bruford, 1998;Penn and Potts, 1999). A number of adaptive hypotheses, which are not necessarily mutually exclusive, have been proposed to explain how MHC could influence mating behaviour and reproductive success.…”

Section: Mhc-dependent Sexual Selection Mate Choice and The Mhcmentioning

confidence: 99%

“…Several studies have implicated olfaction as a mechanism by which an individual can assess the MHC type of another congener (Brown and Eklund, 1994). Although the process is not fully understood, MHC genes can affect the concentration of volatile acids that produce odour in sweat or urine (Yamazaki et al, 1979;Singh et al, 1987;Wedekind et al, 1995;Wedekind and Furi, 1997;Hurst et al, 2001;Beauchamp and Yamazaki, 2003;Santos et al, 2004).…”

Section: Mhc-dependent Sexual Selection Mate Choice and The Mhcmentioning

confidence: 99%

The evolutionary ecology of the major histocompatibility complex

2005

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The major histocompatibility complex (MHC) has become a paradigm for how selection can act to maintain adaptively important genetic diversity in natural populations. Here, we review the contribution of studies on the MHC in non-model species to our understanding of how selection affects MHC diversity, emphasising how ecological and ethological processes influence the tempo and mode of evolution at the MHC, and conversely, how variability at the MHC affects individual fitness, population dynamics and viability. We focus on three main areas: the types of information that have been used to detect the action of selection on MHC genes; the relative contributions of parasite-mediated and sexual selection on the maintenance of MHC diversity; and possible future lines of research that may help resolve some of the unanswered issues associated with MHC evolution.

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“…The simulated values for full-sib pairings, for both sets of dosage rules, increase with both Land n, and approximate the empirical values only when there are at least four loci and a ing, clonal animals, can distinguish self from unrelated conspecific nonself with nearly unerring precision (reviewed in Buss 1987;Grosberg 1988). To the extent that this specificity is genetically controlled, the loci governing invertebrate allorecognition specificity may exhibit polymorphism that rivals, or exceeds, levels recorded at loci in the vertebrate Major Histocompatibility Complex (Potts and Wakeland 1990;Hughes and Nei 1992;Brown and Ecklund 1994;Hedrick 1994), as well as loci associated with gametophytic incompatibility systems in angiosperms (Ebert et al 1989). High levels of allotypic specificity could, however, result from any number of genetic alternatives, ranging from one or a few loci with tens to hundreds of alleles per locus (characteristic of populations of botryllid ascidians : Milkman 1967;Mukai and Watanabe 1975a,b;Scofield et al 1982;Grosberg and Quinn 1986;Rinkevich and Saito 1992;Yund and Feldgarden 1992;Rinkevich et al 1994) to numerous independent loci with relatively low levels of allelic variation (Curtis et al 1982).…”

Section: Simulated Frequencies Of Compatibility In Full and Halfmentioning

confidence: 89%

EVOLUTIONARY GENETICS OF ALLORECOGNITION IN THE COLONIAL HYDROID HYDRACTINIA SYMBIOLONGICARPUS

1996

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Abstract.-Many sedentary, clonal marine invertebrates compete intensively with con specifics for habitable space. Allorecognition systems mediate the nature and outcome of these intraspecific competitive interactions, such that the initiation of agonistic behavior and the potential for intergenotypic fusion depend strongly on the relatedness of the contestants. The dependence of these behaviors on relatedness, along with the extraordinary precision with which self can be discriminated from nonself, suggest that allorecognition systems are highly polymorphic genetically. However, allotypic specificity of this sort could be produced by any number of genetic scenarios, ranging from relatively few loci with abundant allelic variation to numerous loci with relatively few alleles per locus. At this point, virtually nothing is known of the formal genetics of allorecognition in marine invertebrates; consequently, the evolutionary dynamics of such systems remain poorly understood. In this paper, we characterize the formal genetics of allorecognition in the marine hydrozoan Hydractinia symbiolongicarpus. Hydractinia symbiolongicarpus colonizes gastropod shells occupied by hermit crabs. When two or more individuals grow into contact, one of three outcomes ensues: fusion (compatibility), transitory fusion (a temporary state of compatibility), and rejection (incompatibility, often accompanied by the production of agonistic structures termed hyperplastic stolons). Observed patterns of compatibility between unrelated, half-sib pairs, and full-sib pairs show that unrelated and half-sib pairs under laboratory culture have a very low probability of being fusible, whereas full sibs have a roughly 30% rate of fusion in experimental pairings. The genetic simulations indicate that roughly five loci, with 5-7 alleles per locus, confer specificity in this species. In ecological terms, the reproductive ecology of H. symbiolongicarpus should promote the cosettlement of kin, some of which should be full sibs, and some half sibs. Thus, there is potential for kin selection to playa major role in the evolution of the H. symbiolongicarpus allorecognition system. In genetic terms, this system conforms to theoretical predictions for a recognition system selected to distinguish among classes of kin, in addition to self from nons elf.

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Kin Recognition and the Major Histocompatibility Complex: An Integrative Review

Cited by 239 publications

References 112 publications

Wild female baboons bias their social behaviour towards paternal half-sisters

Wild female baboons bias their social behaviour towards paternal half-sisters

The evolutionary ecology of the major histocompatibility complex

EVOLUTIONARY GENETICS OF ALLORECOGNITION IN THE COLONIAL HYDROID HYDRACTINIA SYMBIOLONGICARPUS

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