Kimura's disease with oral ulcers: Response to pentoxifylline

Hongcharu, Wichai; Baldassano, Marisa; Taylor, Charles R.

doi:10.1067/mjd.2000.101931

Cited by 31 publications

(4 citation statements)

References 19 publications

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“…The male-to-female ratio of 18 cases was 3.5:1, similar to the reported sex distribution in all KD patients (male: female 3.5-6:1) [2,9]. The medium age at onset was 47, ranging from 3 to 63, older than the onset age reported by the previous literature [5,10]. Palate (61.1) was the most common location, followed by buccal mucosa.…”

Section: Discussionsupporting

confidence: 83%

A Rare Kimura’s Disease in the Oral Cavity with Severe Sleep Apnea: Case Report and Literature Review

Lei

Feng

et al. 2022

Medicina

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Kimura’s disease (KD) is a rare chronic inflammatory disorder that commonly occurs in Asian males. It mainly presents as painless subcutaneous masses or lymphadenopathy in the head and neck region. The incidence of KD in the oral cavity is quite rare. We reported a rare case of a 53-year-old male who had KD in his soft palate, hard palate and bilateral tonsils associated with severe sleep apnea. This patient underwent radiotherapy and exhibited a good response to the treatment. Throughout the 12-month follow-up period, the patient’s condition remained satisfactory. Of the other 14 reviewed cases of KD in the oral cavity, the lesions can occur in the buccal mucosa, hard and soft palate, and mouth floor with specific clinical features. We further summarized their manifestations and treatments in order to guide the future identification and management of KD with lesions in the oral cavity.

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Section: Discussionsupporting

confidence: 83%

A Rare Kimura’s Disease in the Oral Cavity with Severe Sleep Apnea: Case Report and Literature Review

Lei

Feng

et al. 2022

Medicina

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“…These methods include retinoids, immunosuppressants, monoclonal antibodies (imatinib), antiallergenic drugs (suplatast tosilate and cetirizine), leukotriene-receptor blocker (panlukast), and pentoxifylline [15] with variable effect [11]. …”

Section: Discussionmentioning

confidence: 99%

Kimura’s Disease in a Caucasian Female: A Very Rare Cause of Lymphadenopathy

Osuch‐Wójcikiewicz

Bruzgielewicz

Lachowska

et al. 2014

Case Reports in Otolaryngology

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Introduction. Kimura's disease is a rare chronic inflammatory disorder characterized by the head and neck lymphadenopathy often accompanied by eosinophilia and elevated serum IgE. It is benign condition with unknown etiology usually affecting young men of Asian race. Affected Caucasians are very rare. Case Presentation. We report a clinically and histopathologically typical case of this disease in a 40-year-old Caucasian female. In differential diagnosis particular attention has been paid to angiolymphoid hyperplasia with eosinophilia and neoplasms. Conclusion. The diagnosis of Kimura's disease can be very difficult and misleading; it is important not to ignore histopathological features. The presented patient has been under follow-up with no more symptoms of the disease for the last 1.5 years.

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“…Intravenous immunoglobulin (IVIG) was used in one patient as a steroid-sparing agent, and he remained disease free more than 6 years after follow-up [18]. Oral pentoxifylline has been reported to be effective in one patient with Kimura's disease; however, the lesions relapsed after discontinuation of therapy [19]. All trans-retinoic acid in combination with prednisone has resulted in remission of Kimura's disease in one patient, and he remained disease free 12 months after discontinuation of all therapy.…”

Section: Discussionmentioning

confidence: 99%

Kimura’s Disease—A Rare Cause of Head and Neck Swelling

Rao¹,

Kumar²

2014

IJOHNS

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Kimura's disease (KD) is a chronic inflammatory disorder with unknown etiology, most commonly manifesting as painless unilateral cervical lymphadenopathy or subcutaneous masses in the head or neck region. The disease is characterized by a triad of painless subcutaneous masses in the head or neck region, blood and tissue eosinophilia, and markedly elevated serum immunoglobulin E levels. Kimura's disease is an unusual vascular tumor that typically occurs at 20 to 30 years of age. There has been no documented case of malignant transformation; however, recurrence rates after excision may be as high as 25%. Surgery and medical therapy are useful for treatment. We present a 14 years old male developed a unilateral cervical mass associated with KD. It was a recurrence of disease. As a complete excisional resection of the mass already done 1 year back at some other centre, we decided to give medical treatment for Kimura's disease.

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Kimura's disease with oral ulcers: Response to pentoxifylline

Cited by 31 publications

References 19 publications

A Rare Kimura’s Disease in the Oral Cavity with Severe Sleep Apnea: Case Report and Literature Review

A Rare Kimura’s Disease in the Oral Cavity with Severe Sleep Apnea: Case Report and Literature Review

Kimura’s Disease in a Caucasian Female: A Very Rare Cause of Lymphadenopathy

Kimura’s Disease—A Rare Cause of Head and Neck Swelling

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