Kimura's disease with oral ulcers: Response to pentoxifylline

Kimura’s disease: An unusual glandular involvement with blood and tissue esinophilia

“…Various therapeutic modalities have been tried for the treatment of Kimura's disease with varying degree of successes, which include observation, corticosteroids, immunosuppressive agent (e.g., Cyclosporine and Cyclophospamide), surgery and/or radiotherapy, Interferon alpha, Pentoxyphyline, cryotherapy, cytotoxic agent (Vinblastin) and Montelukast. [8][9][10] Steroids and other immunosuppressive agents have been shown to decrease the size of the lesion, but it tends to recur when these drugs are discontinued. However, in the index case there was no consistent response to Steroids or Cyclosporine or Montelukast.…”

Kimura’s Disease: A Diagnostic Challenge

“…3,4,7 The disease usually involves subcutaneous tissues, lymph nodes (periauricular, axillary, and inguinal), 7,8 parotid and submandibular salivary glands, 9 and rarely, oral mucosa. 10 Other unusual sites of involvement include the auricle, 11 scalp, and orbit. 12 The clinical course of Kimura's disease is generally benign and self-limited.…”

“…3 Other therapeutic options, including radiation, 24 systemic corticosteroids, cytotoxic agents, cyclosporin, and pentoxifylline, have all been tried with variable responses. 10,[22][23][24] Regrowth of the lesion is common after discontinuing such treatments. 22 In addition, the risks from radiation and chronic steroid therapy pose limitations.…”

Kimura’s Disease: A Case Report in a Child

“…• Oral pentoxifylline has been reported to be effective in one patient with Kimura's disease; however, the lesions relapsed after discontinuation of therapy [15].…”