Kimura’s disease: a rare cause of chronic neck lymphadenopathy

Kok, Kenneth Y.Y.; Lim, Edwin

doi:10.1093/jscr/rjab318

Cited by 8 publications

(3 citation statements)

References 13 publications

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“…The diffuse interfollicular in ltrates are rich in eosinophils, lymphocytes, plasma cells, and mast cells. Sometimes, several eosinophilic microabscesses and brosis are observed [9,15]. Histologically, lymphocytic eosinophilic hyperplasia (ALHE) is similar to KD and commonly affects women in the third to fourth decade of life.…”

Section: Discussionmentioning

confidence: 99%

Kimura Disease: A Rare Case in Vietnamese Woman

Le,

Tran,

Pham

2023

Preprint

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Background: Kimura disease (KD) is a rare benign chronic inflammatory condition that predominantly affects Asian males. It is characterized by subcutaneous tissue masses in the head and neck region, enlarged lymph nodes, increased blood eosinophilia, and elevated serum total IgE levels. In this report, we describe a rare case of KD in a young Vietnamese female. Case summary: A 31-year-old Vietnamese woman presented to the hospital with 2 masses in the bilateral cheeks and 1 mass behind the left ear that persisted for 15 years, recurrent skin itching, elevated serum total IgE levels and increased blood eosinophilia. No medical history of the individual or family was recorded. We performed an excision biopsy of the postauricular mass which revealed follicular hyperplasia with small vessel hyperplasia, diffuse infiltration of eosinophils in lymphoid follicles, and several eosinophilic microabscesses. After a comprehensive review, the final diagnosis for this patient was KD and atopic dermatitis comorbidity. Conclusion: KD is not limited to males, as this report demonstrated. The histopathological examination plays an important role in the diagnosis of KD. This case illustrated the characteristic description of KD and highlights the need for awareness of this rare disease in Asian women.

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Section: Discussionmentioning

confidence: 99%

Kimura Disease: A Rare Case in Vietnamese Woman

Le,

Tran,

Pham

2023

Preprint

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“… 2 , 3 Laboratory tests showed eosinophilia and immunoglobulin E (IgE) increase in peripheral blood. 4 Histopathology was the gold standard for diagnosis, including marked lymphoid follicular hyperplasia with enlargement of germinating centers, eosinophilic infiltration, accumulation of eosinophilic microabscesses, proliferation of lymphocytes and mast cells around capillaries and venules, with surrounding deposition of circular collagen fibers and varying degrees of fibrosis. 5 …”

Section: Introductionmentioning

confidence: 99%

An Unusual Case of Systemic Lymphadenopathy - Kimura’s Disease

Liu¹,

Liu²,

Xu³

et al. 2023

JIR

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Background Kimura’s disease (KD) is a rare, chronic inflammatory disease. Clinically, subcutaneous nodules of the head and neck are typical manifestations, often accompanied by local lymphadenopathy or salivary gland enlargement, but there is also systemic damage, such as kidney involvement. Due to the lack of specific markers and imaging examination is not specific, it is difficult to clinically diagnose accurately and can be easy to misdiagnose. The treatment of KD is still not standardized and overtreatment can affect the quality of life. Case Presentation The case of a 26-year-old man complaining of chest pain with self-conscious progressive lymphadenopathy after receiving Pfizer BioNTech COVID-19 vaccine for more than 1 month is presented. Eosinophil levels were normal and IgE elevated and the final diagnosis of KD was eventually confirmed by lymph node biopsy, which revealed lymphadenopathy with extensive eosinophilic infiltration in the right neck. Treatment was prednisone combined with methotrexate, resulting in satisfactory control. Conclusion This case demonstrates that that Kimura disease can involve systemic lymphadenopathy, not only in the head and face or regional lymphadenopathy, suggested that KD should be excluded in patients with systemic lymphadenopathy. The current patient’s response to treatment suggested that corticosteroid combined with disease-modifying antirheumatic drugs (DENARDs) was a promising treatment for KD patients with systemic damage. It is worth noting that the mechanism of immunity in the pathogenesis of KD still needs to be further studied.

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“… 1 , 2 Frequently seen in young men, Kimura’s disease is usually featured by elevated serum IgE and peripheral blood eosinophilia. 3 Currently, the preferred treatment strategy for Kimura’s disease is not well established. Available treatment options for Kimura’s disease include surgical excision, local radiation, regional or systemic steroid therapy.…”

Section: Introductionmentioning

confidence: 99%