Kimura's Disease: A Case Report

Abstract

Kimura's disease is a rare, idiopathic condition that usually affects young men of Asian descent. The disease is characterized by swelling and lesions in the head and neck region, with involvement of the subcutaneous soft tissue, major salivary glands, and lymph nodes. Patients almost always have eosinophilia and elevated serum immunoglobulin E levels. The diagnosis is established by biopsy. Kimura's disease is usually self-limiting. Its etiology is unknown but is thought to be a manifestation of an aberrant allergic response. In this paper, we describe the case of a 30-year-old patient who was diagnosed with Kimura's disease at our institution.

Extranodal manifestation of Kimura's disease: ultrasound features

“…Patients with overlapping features of KD and ALHE have been reported [9]. It is now considered, however, that they are different entities with distinct clinicopathological features [1,2,8,10].…”

“…The incidence is higher in men (male:female ratio = 3:1) with a mean age of 26 years (age range 3±71 years) [2,7]. The onset is insidious and usually asymptomatic.…”

“…Peripheral blood oeosinophilia and raised serum IgE level are consistent findings. Nephrotic syndrome is found in 12 % of patients [2]. A unilateral large solitary mass with cervical nodal enlargement, salivary gland involvement and elevated IgE level are prominent clinical features of KD [2,7].…”

“…It was first reported by Kim and Sezto in 1937 and was later described by Kimura in 1948. Since then, there have been over 100 reported cases in the literatures [1,2]. Sporadic imaging examinations including US, CT, MR imaging and radiopharmaceutical studies of KD have been reported [3].…”

Radiology Quiz Case 2—Diagnosis

“…When the parotid gland is involved, there is also the risk of damaging the facial nerve. 1 3 Adjuvant therapy after surgery or local recurrence includes cryotherapy, steroid administration (systemic or intralesional), and laser treatment.…”