Kimura Disease of the Breast - A Previously Undescribed Entity

Kakkar, Aanchal; Gupta, Rakesh Kumar; Khanna, Poonam; Balasundaram, Partheeban; Ray, Ruma; Shukla, Nootan Kumar

doi:10.1111/tbj.12603

Cited by 6 publications

(7 citation statements)

References 10 publications

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“…Kimura disease is a rare chronic inflammatory disease of unknown origin, first described by Kimura et al in 1948 1 . To date, there have only been 200 reported incidences of Kimura disease globally, 2 and only 1 reported case of Kimura Disease of the Breast in 2016 3 . Kimura disease predominantly occurs in Asian male populations, with incidence peaking around the second and third decade of life 4,5 …”

Section: Discussionmentioning

confidence: 99%

Kimura disease of the breast: Case report and literature review of current management

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Kimura disease of the breast: Case report and literature review of current management

et al. 2020

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“… 1 Breast, as observed in our patient, is an unusual location for disease involvement and, to the best of our knowledge, the first case of KD in the breast was published in the medical literature in 2016 by Kakkar et al who reported a 40-year-old female with breast KD presented with painful breast lump and axillary lymphadenopathy. 3 Later in 2020, another case report described a case of KD of the breast in a 50-year-old Asian female, which had bilateral multifocal breasts masses and bilateral axillary lymphadenopathy. 4 In comparison to the previously reported cases, the distinct presentation of our patient was painless diffuse breast enlargement and axillary lymphadenopathy without palpable breast mass or focal lesion.…”

Section: Discussionmentioning

confidence: 99%

A rarely described Kimura’s disease of the breast

Almohawes,

Zakareia,

Dumiati

et al. 2023

BJR|case reports

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Kimura’s disease is a rare chronic inflammatory disease of unknown aetiology. The majority of cases are reported in middle-aged Asian males and rarely seen in other ethnicities. Patients classically present with chronic single or multiple painless subcutaneous masses, lymphadenopathies, hypereosinophilia and elevated serum immunoglobulin E. The disease usually affects the head and neck area, however, rare involvement of other locations such as axilla, upper limbs, popliteal region and abdomen has been reported. Here, we report a rarely encountered Kimura’s disease of the breast and axillary lymph nodes in a middle-aged female. In this report, we will describe the main clinical, radiological and pathological features to raise the awareness about this indolent disease.

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“…Besides the head and neck, cases with axillary lymph node and breast involvement have also been reported. 15,16 More extensive patterns of disease should prompt consideration of an alternative diagnosis. The key is to follow the clinical course with a low threshold for extensive work up to rule out malignancy in patients who show clinical progression.…”

Section: Discussionmentioning

confidence: 99%

A case series of Kimura’s disease: a diagnostic challenge

Kumar

Mittal²,

Huang

et al. 2018

Therapeutic Advances in Hematology

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Kimura's disease (KD) is a rare, benign disorder characterized by subcutaneous masses with regional lymph-node enlargement. It is considered to be due to chronic inflammation of unclear etiology. Most cases have been reported in young, 20-30-year-old men of Asian descent. The diagnosis of KD is based on pathological features and elevated immunoglobulin E levels. Characteristic pathological features include intact lymph-node architecture, florid germinal center hyperplasia, extensive eosinophilic infiltrates, and proliferation of postcapillary venules. However, these features can also be seen in Hodgkin's disease or T-cell lymphoma, therefore, cases presenting as KD pose a diagnostic challenge. We report a case series of two cases with suspected KD at initial presentation, with one patient eventually diagnosed with Hodgkin's disease after clinical progression. The first case was a 45-year-old Asian man who presented with bilateral thigh masses and significantly enlarged inguinal lymph nodes. The histopathology was characteristic and the patient had stable disease on treatment with cetirizine for 20 months. The second case was a 29-year-old African-American man who had progressive enlargement of the right neck lymph nodes extending into the mediastinum, with the original biopsy suggestive of KD. An initial search for Reed-Sternberg cells using immunohistochemical staining for CD15 and CD30 was negative. However, the patient developed neurological symptoms corresponding to tumor extension to the cervical and thoracic neural foramina. A repeat biopsy showed a lack of nodal structure and atypical large cells that were positive for CD30 staining. The patient was treated with chemotherapy with good response. We emphasize the importance of following the clinical course to render an accurate diagnosis. Both cases showed extensive eosinophilic infiltration and other KD-like pathological features. However, KD is rare; not missing a malignant diagnosis lies in high clinical suspicion and repeated exhaustive work up.

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Kimura Disease of the Breast - A Previously Undescribed Entity

Cited by 6 publications

References 10 publications

Kimura disease of the breast: Case report and literature review of current management

Kimura disease of the breast: Case report and literature review of current management

A rarely described Kimura’s disease of the breast

A case series of Kimura’s disease: a diagnostic challenge

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