Killing two birds with one stone: phosphorylation by a tabun mimic and subsequent capture of cyanide using a single fluorescent chemodosimeter

Mia, Rashid; Cragg, Peter J.; Fronczek, Frank R.; Wallace, Karl J.

doi:10.1039/d2nj04014j

Cited by 2 publications

(3 citation statements)

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“…The oximate moiety, a supernucleophile, can undergo a fast chemical reaction with organophosphates to form an organophosphate adduct. The synthesis of probe 1 and its photophysical property changes that occur upon the addition of organophosphates, for example, diisopropyl fluorophosphate (DFP), are based on previously published work [29,30]. See Figure 2 for the molecular structures of probe 1, DFP, and O,S-DEMPT that were used in this study.…”

Section: Resultsmentioning

confidence: 99%

“…This change is due to the formation of a covalent bond between the oxime of probe 1 and the phosphorous center of DFP because of phosphorylation. In addition, oxidation peak IV shows a marginal shift of ~0.05 V from 1.64 V to 1.59 V, which is due to the disruption of the structure of the enamine moiety in probe 1 by free F− ions from the DFP simulant [29]. As shown in Figure 6, upon the addition of the thiol-containing nerve agent mimic O,S-DEMPT, a new distinct peak V, most likely as a result of the thiol oxidation, emerged at 1.85 V. Oxidation peak III also showed a similar shift of ~0.13 V upon the addition of O,S-DEMPT, which is similar to the results observed previously with the DFP simulant.…”

Section: Electrochemical Detection Of Cwasmentioning

confidence: 96%

“…All chemicals, including silver nitrate, tetrabutylammonium perchlorate (TBAP), diisopropyl fluorophosphate (DFP), and O,S-dimethylmethylphosphonate (O,S-DEMPT), in this study were purchased from Sigma-Aldrich, St. Louis, MO, USA and used without further purification. The coumarin derivative probe 1 was synthesized according to a procedure from the literature [29,30]. Glassy carbon electrode (GCE), silver wire, and platinum (Pt) mesh were obtained from CH Instruments, Inc., Austin, TX, USA.…”

Section: Reagentsmentioning

confidence: 99%

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Toward Remote Detection of Chemical Warfare Simulants Using a Miniature Potentiostat

Dawoud,

Mia,

Motchaalangaram

et al. 2024

Micro

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A miniaturized electrochemical sensor was developed for the remote detection of chemical warfare agent (CWA) simulants. To facilitate drone-based remote sensing, this present study focuses on advancing the miniaturized and compact electrochemical sensor for monitoring two CWA simulants, diisopropyl fluorophosphate (DFP) and O,S-diethylmethylphosphonothioate (O,S-DEMPT). The differential pulse voltammetry (DPV) signal was processed, and the DPV signature features were extracted on the basis of the redox properties associated with the absence and the presence of DFP and O,S-DEMPT. Upon the addition of 0.10 equivalence of DFP or O,S-DEMPT, a shift in potential (E) of ~0.13 V was recorded. The limit of detection (LOD) was calculated to be 0.25 µM (0.046 ppm) and 0.10 µM (0.017 ppm) for DFP and O,S-DEMPT, respectively. These results were validated using a portable Palmsens Emstat HR potentiostat, which corroborated the results obtained using a lab benchtop potentiostat. Additionally, Boolean logic (“AND” operation) was implemented for future drone technology deployment. This advancement enables the fabrication of a networked device capable of autonomously executing tasks without constant oversight.

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Section: Resultsmentioning

confidence: 99%

Section: Electrochemical Detection Of Cwasmentioning

confidence: 96%

Section: Reagentsmentioning

confidence: 99%

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