Killing Two Birds with One Stone: Potential Therapies Targeting Psoriasis and Atherosclerosis at the Same Time

Šabović, Eva Klara Merzel; Zorko, Milena; Janić, Miodrag

doi:10.3390/ijms23126648

Cited by 3 publications

(2 citation statements)

References 115 publications

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“…As regular moderate-to-vigorous PE has essential anti-inflammatory and antioxidative abilities, a significant question is what dose of PE and intensity is needed to reduce the risk of psoriasis. Evidence has long demonstrated that patients with psoriasis take up less intensive PA than those without psoriasis [ 4 , 75 ] and have a higher risk of developing cardiovascular disease, obesity, and metabolic alteration, among others [ 86 ]. In recent years, two reviews and meta-analyses have quantified the association of psoriasis with PA [ 4 , 75 ].…”

Section: Resultsmentioning

confidence: 99%

The Impact of Diet and Physical Activity on Psoriasis: A Narrative Review of the Current Evidence

et al. 2023

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Psoriasis is an inflammatory disease with strong genetic links and numerous features of autoimmunity that are also influenced by environment and lifestyle, including nutritional factors and physical activity (PA), with regards to the condition of patients. Recent reports in the field of nutrigenomics indicate a significant impact of nutrients in modulating microRNAs. However, few studies have evaluated the effect of nutritional systems and PA on treating psoriasis. This narrative review updates information regarding the current dietary recommendations for individuals with psoriasis and discusses the role of diet and PA in psoriasis prevention and treatment. Application of nutrigenetics in psoriasis therapy is also discussed. The PubMed and Google Scholar databases were searched using the MeSH terms for “nutrigenomics”, “dietetics”, “diet therapy”, “diet”, “physical activity”, and “exercise” in conjunction with the MeSH terms for “psoriasis” and “dermatology”. Evidence has shown that patients with psoriasis should have a personalized anti-inflammatory diet. Psoriasis patients are less physically active; most performed exercises of low-to-moderate intensity and were less likely to undertake regular exercise. Identifying nutrigenomic discoveries and the current lifestyle interventions associated with psoriasis can help physicians and physical therapists develop educational programs to manage and protect against the disease.

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Section: Resultsmentioning

confidence: 99%

The Impact of Diet and Physical Activity on Psoriasis: A Narrative Review of the Current Evidence

et al. 2023

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“…Mercel Šabović et al [ 11 ], in a review article, present the common pathophysiological mechanisms of the psoriasis and cardiometabolic disorders and the atherosclerotic impact of some psoriasis treatments. The authors point out future perspectives in the treatment of psoriasis that should be accompanied by medications that target psoriasis-driven atherosclerosis.…”

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confidence: 99%

New Insights into Psoriasis

Nedoszytko

Owczarczyk‐Saczonek

Krasowska

et al. 2022

IJMS

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Management of psoriatic arthritis: a consensus opinion by expert rheumatologists

D’Angelo,

Atzeni,

Benucci

et al. 2023

Front. Med.

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BackgroundPsoriatic arthritis (PsA) is a chronic inflammatory musculoskeletal disease involving several articular and extra-articular structures. Despite the important progresses recently made in all of the aspects of this disease, its management is still burdened by unresolved issues. The aim of this exercise was to provide a set of statements that may be helpful for the management of PsA.MethodsA group of 38 Italian rheumatologists with recognized expertise in PsA selected and addressed the following four topics: “early PsA,” “axial-PsA,” “extra-articular manifestations and comorbidities,” “therapeutic goals.” Relevant articles from the literature (2016–2022) were selected by the experts based on a PubMed search. A number of statements for each topic were elaborated.ResultsNinety-four articles were selected and evaluated, 68 out of the 1,114 yielded by the literature search and 26 added by the Authors. Each of the four topic was subdivided in themes as follows: transition from psoriasis to PsA, imaging vs. CASPAR criteria in early diagnosis, early treatment for “early PsA”; axial-PsA vs. axialspondyloarthritis, diagnosis, clinical evaluation, treatment, standard radiography vs. magnetic resonance imaging for “axial PsA”; influence of inflammatory bowel disease on the therapeutic choice, cardiovascular comorbidity, bone damage, risk of infection for “comorbidities and extra-articular manifestations”; target and tools, treat-to-target strategy, role of imaging for “therapeutic goals.” The final document consisted of 49 statements.DiscussionThe final product of this exercise is a set of statements concerning the main issues of PsA management offering an expert opinion for some unmet needs of this complex disease.

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Killing Two Birds with One Stone: Potential Therapies Targeting Psoriasis and Atherosclerosis at the Same Time

Cited by 3 publications

References 115 publications

The Impact of Diet and Physical Activity on Psoriasis: A Narrative Review of the Current Evidence

The Impact of Diet and Physical Activity on Psoriasis: A Narrative Review of the Current Evidence

New Insights into Psoriasis

Management of psoriatic arthritis: a consensus opinion by expert rheumatologists

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