Killer‐cell immunoglobulin‐like receptor (KIR) nomenclature report, 2002

“…Despite extensive sequence similarity in the extracellular domains, activating KIRs frequently have altered ligand speciWcity compared to their cognate inhibitory molecules [22]. KIR nomenclature reXects the structure of the molecule [23]. For example, a name beginning with KIR3DL signiWes a molecule with three Ig domains that is inhibitory (long cytoplasmic tail) whereas KIR2DS indicates that molecule contains two Ig domains and a short cytoplasmic tail.…”

Section: Killer-immunoglobulin-like Receptorsmentioning

confidence: 98%

KIRigami: the case for studying NK cell receptors in SIV+ macaques

Bimber

O’Connor

2007

Immunol Res

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Genes of the major histocompatibility complex (MHC) are one of the most significant genetic predictors of HIV and SIV disease outcome; however, in no case is MHC genotype alone sufficient to account for this durable HIV/SIV control. Killer immunoglobulin-like receptors (KIRs) interact with MHC molecules and have been implicated in control of HIV replication. They provide an attractive candidate to act in concert with protective MHC alleles in promoting viral control. While there is ample data demonstrating the association between KIR genotype and improved disease course, little is known about the mechanism through which KIRs promote HIV protection. As with MHC studies, macaques provide an important experimental model in which to address the role of KIRs in disease pathogenesis. This review focuses on the current understanding of the role of KIRs in HIV infection and outstanding questions for future study.

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“…Killer cell immunoglobulin-like receptors (KIRs) on NK cells show extensive variation in terms of gene content among different individuals. Fifteen functional KIR genes and two KIR pseudogenes have been identified (1). Because HLA and KIR independently segregate on different chromosomes, only a minority of HLA-matched transplants is KIR-matched (2)(3)(4).…”

Section: Introductionmentioning

confidence: 99%

Donor Killer Immunoglobulin-Like Receptor Profile Bx1 Imparts a Negative Effect and Centromeric B-Specific Gene Motifs Render a Positive Effect on Standard-Risk Acute Myeloid Leukemia/Myelodysplastic Syndrome Patient Survival after Unrelated Donor Hematopoietic Stem Cell Transplantation

Bao¹,

Wang²,

Zhou³

et al. 2016

Biology of Blood and Marrow Transplantation

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Donor killer immunoglobulin-like receptor (KIR) group B profiles (Bx) and homozygous of centromeric motif B (Cen-B/B) are the most preferable KIR gene content motifs for hematopoietic stem cell transplantation (HSCT). The risk of transplant from Bx1 donors and the benefit of the presence of Cen-B (regardless of number) were observed for standard-risk acute myeloid leukemia/myelodysplastic syndrome (AML/MDS) patients in this 4-year retrospective study. A total of 210 Chinese patients who underwent unrelated donor HSCT were investigated. Donor KIR profile Bx was associated with significantly improved overall survival (OS; P = .026) and relapse-free survival (RFS; P = .021) and reduced nonrelapse mortality (NRM; P = .017) in AML/MDS patients. A significantly lower survival rate was observed for transplants from Bx1 donors compared with Bx2, Bx3, and Bx4 donors for patients in first complete remission (n = 82; OS: P = .024; RFS: P = .021). Transplant from donors with Cen-B resulted in improved OS (HR = .256; 95% CI, .084 to .774; P = .016) and RFS (HR = .252; 95% CI, .084 to .758; P = .014) in AML/MDS patients at standard risk. However, this particular effect did not increase with a higher number of Cen-B motifs (cB/B versus cA/B; OS: P = .755; RFS: P = .768). No effect was observed on high-risk AML/MDS, acute lymphoblastic leukemia/non-Hodgkin lymphoma, and chronic myelogenous leukemia patients. Avoiding the selection of HSCT donors of KIR profile Bx1 is strongly advisable for standard-risk AML/MDS patients. The presence of the Cen-B motif rather than its number was more important in donor selection for the Chinese population.

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Killer‐cell immunoglobulin‐like receptor (KIR) nomenclature report, 2002

Cited by 233 publications

References 34 publications

Comparative genomic analysis, diversity and evolution of two KIR haplotypes A and B

Comparative genomic analysis, diversity and evolution of two KIR haplotypes A and B

KIRigami: the case for studying NK cell receptors in SIV+ macaques

Donor Killer Immunoglobulin-Like Receptor Profile Bx1 Imparts a Negative Effect and Centromeric B-Specific Gene Motifs Render a Positive Effect on Standard-Risk Acute Myeloid Leukemia/Myelodysplastic Syndrome Patient Survival after Unrelated Donor Hematopoietic Stem Cell Transplantation

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