Kikuchi's disease: Case report and systematic review of cutaneous and histopathologic presentations

The cutaneous lesions of Kikuchi's disease: a comprehensive analysis of 16 cases based on the clinicopathologic, immunohistochemical, and immunofluorescence studies with an emphasis on the differential diagnosis

“…We agree with the series of 5 cases by Spies et al [8] and a systemic review by Atwater et al [4]; we propose the diagnostic criteria in Table 5. It is important to recognize the cutaneous lesions of KD, which is a selflimited disorder, because more invasive diagnostic procedures, such as lymph node biopsy, can be avoided in cases with the aforementioned histopathologic findings and clinical manifestations and especially a fever of unknown origin or lymphadenopathy.…”

“…The cutaneous manifestations of KD are common and can be quite variable, but erythematous macules, papules, or patches were the most common findings in this study and in previous studies [4]. The skin eruptions were located on the face and upper extremities and also on the lower extremities and trunk.…”

“…These features have also been described in the literature [4,[6][7][8][9]. Pityriasis lichenoides is a papulosquamous disorder and includes pityriasis lichenoides chronica and pityriasis lichenoides et varioliformis acuta (PLEVA).…”

“…It has been reported that 16.6% to 40% of the patients with KD have cutaneous involvement, and this was first described by Kuo [2] in 1990. The cutaneous manifestations and histopathologic findings are variable [3,4], and the description of the histopathologic findings of such skin lesions is limited to one case series and several case reports that include reviews of the literature [2][3][4][5][6][7][8][9][10]. It has been difficult for pathologists to make a specific diagnosis based on skin biopsy specimens.…”

A Case of Kikuchi's Disease Presenting with Unique Facial Involvement

“…Other symptoms may include leucopenia, liver dysfunction, weight loss, diarrhea, nausea, vomiting, myalgia, and arthralgia 3,4 . Less frequently, KD involves skin lesions as erythematous macules, papules, patches, and plaques on the scalp, chest, back and extremities 5,6 . We report a 20-year-old Korean woman with KD that showed unique skin involvement with symmetrically distributed, erythematous, firm nodules limited to the face.…”