Kikuchi's disease: A case report from south India

P, Sathyamurthy; Indhumathi, E; Rajendran, Amarabalan; Vivek, Bavya

doi:10.5348/ijcri-2011-02-20-cr-4

Cited by 5 publications

(3 citation statements)

References 7 publications

(9 reference statements)

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“…KFD is an uncommon benign condition of necrotizing histiocytic lymphadenitis commonly seen in East Asian and Japanese populations, and it was first described by Kikuchi and Fujimoto in 1972 [2]. Males are affected rarely with a male to female ratio of 1:4 [5]. KFD can be associated with other autoimmune disorders especially SLE [2].…”

Section: Discussionmentioning

confidence: 99%

Kikuchi–Fujimoto disease associated with systemic lupus erythematosus complicated with hemophagocytic lymphohistiocytosis: a case report

et al. 2019

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Background Kikuchi–Fujimoto disease, which was originally described in young women, is a benign condition characterized by necrotizing lymphadenitis and fever. Even though the clinical course is usually self-limiting, it can be associated with recurrences and rarely can be associated with systemic lupus erythematosus or can be complicated with hemophagocytic lymphohistiocytosis. We report the case of a 17-year-old Sri Lankan Sinhalese schoolboy who presented with fever and cervical lymphadenopathy diagnosed as Kikuchi–Fujimoto disease and was complicated with hemophagocytic lymphohistiocytosis subsequently. Later he fulfilled the criteria for systemic lupus erythematosus. Case presentation A 17-year-old previously healthy Sinhalese schoolboy presented with high-grade fever associated with chills and rigors associated with loss of appetite and loss of weight for more than 40 days. On examination, he had bilateral firm matted tender cervical lymphadenopathy and firm hepatomegaly. An excision biopsy of his right cervical lymph node revealed necrotizing lymphadenitis and immunohistochemistry of a lymph node biopsy favored Kikuchi disease. Initial antinuclear antibody and anti-double-stranded deoxyribonucleic acid tests were negative and his C3 and C4 levels were normal. An infections screening was negative. He was treated with steroids. While in hospital he developed hemophagocytic lymphohistiocytosis and renal impairment. Later his antinuclear antibody titer became positive in 1:160 and fulfilled the diagnostic criteria for systemic lupus erythematosus. He was managed with steroids and immune suppressive drugs and showed remarkable improvement. Conclusion Although Kikuchi–Fujimoto disease is uncommon in male patients, it needs to be considered in patients with lymphadenopathy and fever. The disease can be complicated with hemophagocytic lymphohistiocytosis and the patients need continuous monitoring for the possible development of systemic lupus erythematosus later in the course.

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Section: Discussionmentioning

confidence: 99%

Kikuchi–Fujimoto disease associated with systemic lupus erythematosus complicated with hemophagocytic lymphohistiocytosis: a case report

et al. 2019

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“…In the 11 cases reported from India, involvement of cervical lymph nodes was 100 %. Only one patient had generalized lymphadenopathy [5, 11–16]. In a retrospective study of 195 patients by Cheng et al, only 2.6 % of patients had axillary lymphadenopathy [17].…”

Section: Discussionmentioning

confidence: 99%

“…Raised ESR was found in all patients in a study of six cases by Adhikari et al [7]. Among the six patients reported from India, raised ESR was observed in five cases, and leukopenia and leukocytosis were found in one patient each [5, 11, 13–16]. Thrombocytopenia is rare.…”

Section: Discussionmentioning

confidence: 99%

An uncommon presentation of Kikuchi Fujimoto disease: a case report with literature review

et al. 2015

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BackgroundKikuchi–Fujimoto disease is so named because Kikuchi and Fujimoto were the first scientists to describe it in Japan in 1972. Although the disease has been reported from all over the world and more so from Asia, it is rare. To date only eight cases have been reported from Nepal. Cervical lymphadenopathy, fever and raised Erythrocyte Sedimentation Rate are usual presenting features of this disease. We describe a case which presented with thrombocytopenia and axillary lymphadenopathy in addition to the usual features. Out of the total eight cases that have been reported from Nepal so far, no patients had thrombocytopenia and only one patient had axillary lymphadenopathy.Case presentationA 24-year-old Nepali female presented with a 3-week history of low-grade fever, headache, and painful, discrete, unilateral left-sided cervical and axillary lymphadenopathy. Among the multitude of tests that were carried out, Erythrocyte Sedimentation Rate was raised and there was thrombocytopenia while other tests were normal. Painful lymphadenopathy pointed to bacterial lymphadenitis while chronic low-grade fever suggested tuberculosis. A cervical lymph node was excised for histopathological examination to reach an accurate diagnosis. On the basis of pathognomonic features viz., paracortical foci composed of various types of histiocytes including crescentic type in the background of abundant apoptotic karyorrhectic debris, a diagnosis of Kikuchi–Fujimoto disease was made. On follow-up evaluation after 6 weeks, the patient had no systemic symptoms, enlarged lymph nodes had regressed in size significantly, and Erythrocyte Sedimentation Rate and platelet count had become normal.ConclusionKikuchi–Fujimoto disease should be kept in the differential diagnosis of lymphadenopathy in young patients, female or male even in tuberculosis-endemic countries and even in patients who have unusual features; for example thrombocytopenia and involvement of axillary lymph nodes in addition to cervical lymph nodes as in this case.

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Kikuchi–Fujimoto Disease Presenting as Brachial Plexus Neuritis: A Case Report

Gupta

Kayal

Rajawat

2016

IJNS

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Kikuchi?Fujimoto disease is a rare, idiopathic, self-limiting necrotizing lymphadenitis of unknown etiology. It usually affects young Asian women. Clinically, it closely resembles with tuberculosis or lymphomas. This pathology has occasionally been associated with various cardiac, renal, pulmonary, and other systemic complications. The association of the disease in context to other neurological pathologies is even more sporadic. We report a case of Kikuchi?Fujimoto disease in a 56-year-old woman associated with the rare presentation as brachial plexus neuritis. The diagnosis was established histopathologically upon surgical resection of lesion. We discuss the peculiar features of presentation, pathological elements, surgical management, and postoperative outcome with special emphasis on complications of this clinical entity.

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Kikuchi's disease: A case report from south India

Cited by 5 publications

References 7 publications

Kikuchi–Fujimoto disease associated with systemic lupus erythematosus complicated with hemophagocytic lymphohistiocytosis: a case report

Kikuchi–Fujimoto disease associated with systemic lupus erythematosus complicated with hemophagocytic lymphohistiocytosis: a case report

An uncommon presentation of Kikuchi Fujimoto disease: a case report with literature review

Kikuchi–Fujimoto Disease Presenting as Brachial Plexus Neuritis: A Case Report

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