Kikuchi-Fujimoto disease preceded by lupus erythematosus panniculitis: do these findings together herald the onset of systemic lupus erythematosus?

Pham, Alan; Castillo, Stephanie; Barton, Dorothea T.; Rigby, William F.C.; Guill, Marshall A.; Lucas, R.Clement; LeBlanc, Robert E.

doi:10.5070/d3268049885

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…Due to the possible immune nature of KFD, it is no surprise that the association of KFD with rheumatological autoimmune diseases has been well-documented in the literature, with the KFD diagnosis established before, during, and after SLE and SS [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. Although the first case of KFD is traced to 1972 in Japan where it was described almost simultaneously by Kikuchi and Fujimoto, more and more cases are now being diagnosed in the Western world as well [26,27].…”

Section: Discussionmentioning

confidence: 99%

Kikuchi-Fujimoto Disease With Systemic Lupus Erythematosus and Systemic Sclerosis Overlap: A Unique Clinical Presentation

Rana,

Fatima,

Rana

et al. 2023

Cureus

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Kikuchi-Fujimoto Disease (KFD), or histiocytic necrotizing lymphadenitis (HNL), is a rare self-limiting disorder presenting with fever and swollen lymph nodes. It is characterized by the focal proliferation of reticular cells, the presence of nuclear debris, and histiocytes. In advanced cases, it can present with hepato-splenomegaly and generalized lymphadenopathy. Historically, it has been associated with viral infections, as it frequently was found to be associated with upper respiratory symptoms. Alternative explanations include the immune response of T-cells leading to alteration in CD8-positive T-cell-mediated cell apoptosis. It is also speculated that KFD can be associated with rheumatological autoimmune diseases. We present a case of a 21-year-old African American female with a known diagnosis of systemic lupus erythematosus (SLE)-systemic sclerosis (SS) overlap presented with febrile lymphadenopathy and was diagnosed to have HNL on histological exam of lymph node biopsy.

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Section: Discussionmentioning

confidence: 99%

Kikuchi-Fujimoto Disease With Systemic Lupus Erythematosus and Systemic Sclerosis Overlap: A Unique Clinical Presentation

Rana,

Fatima,

Rana

et al. 2023

Cureus

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Kikuchi-Fujimoto Disease: A Distinct Pathological Entity but also an "Overlap" Autoimmune Syndrome: A Systematic Review

Zaccarelli

Vincentiis

et al. 2023

CRR

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Background: The association between KFD and autoimmune diseases, not only with systemic lupus erythematosus, has been repeatedly described. Objective: The aim of this review is to evaluate whether an overlap syndrome is present between KFD and autoimmune diseases, whether there is a chronological and a casual relationship between the pathologies. Methods: The databases used for the overlap case search were Medline and Embase from which we extrapolated the studies of interest. The search queries used were: Kikuchi-Fujimoto Syndrome and juvenile idiopathic arthritis or systemic lupus erythematosus or Systemic Sclerosis or Antiphospholipid Syndrome or Sjogren's Syndrome. All study types were considered (n=103). Results: total number of included studies are 43. We have shown that there is an "overlap" syndrome between KFD and other autoimmune diseases. The chronology of disease onset was variable; autoimmune disease may be "preceding" (n.=11 cases) or "simultaneous" (n.=20 cases) or "post" (n.=8 cases). Kikuchi-Fujimoto Syndrome. Also, the autoimmune disease can present with a complete clinical picture or only with the presence of autoantibodies. Conclusion: the different pathologies associated with KFD with different chronologies would indicate suggest that there is an alteration of the immune system that allows the autoimmune phenomena pathologies to occur in different temporal relationships.

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Kikuchi-Fujimoto disease preceded by lupus erythematosus panniculitis: do these findings together herald the onset of systemic lupus erythematosus?

Cited by 2 publications

References 29 publications

Kikuchi-Fujimoto Disease With Systemic Lupus Erythematosus and Systemic Sclerosis Overlap: A Unique Clinical Presentation

Kikuchi-Fujimoto Disease With Systemic Lupus Erythematosus and Systemic Sclerosis Overlap: A Unique Clinical Presentation

Kikuchi-Fujimoto Disease: A Distinct Pathological Entity but also an "Overlap" Autoimmune Syndrome: A Systematic Review

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