Kikuchi-Fujimoto disease in fine needle aspiration smears: A clinico-cytologic study of 18 pediatric cases and correlation with 68 adult patients

Das, Dilip K.; Haji, Bahiya I; Al-Boijan, Ruaá A.A; Sheikh, Zafar A.; Pathan, Shahed K.; Mannan, Abul Ala Syed Rifat

doi:10.4103/0377-4929.101739

Cited by 8 publications

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“…In a study comparing clinical-cytological features in adults and children, children were significantly less likely to have high cellularity and Kikuchi histiocyte counts >5% than adults. [19] Our study also showed that the positive rate of EBV, one of the trigger factors of KFD, was higher in children, particularly among boys compared in adults. Although ANA positivity was higher in women than in men, ANA positivity was higher in boys than in girls.…”

Section: Discussionsupporting

confidence: 69%

Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age

Kim¹,

Jo²,

Kim³

2021

Preprint

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Background: Little information exists regarding the differences in the clinical and laboratory characteristics of Kikuchi-Fujimoto disease (KFD) according to age. Objective: To evaluate the clinical and laboratory characteristics of KFD according to age. Methods: We retrospectively evaluated patients diagnosed with KFD at Pusan National University Hospital between 2010 and 2020. Results: Eighty patients (46 children and 34 adults) with a mean age of 21.5 ± 11.8 years (range, 3–49 years) were included in the study. Among children, the male sex ratio was higher, in adults, the female sex ratio was higher. Fever, tenderness in the lymph node, and skin rashes were more common in children, while myalgia and weight loss were more common in adults. In children, the recurrence rate was significantly higher among boys than among girls (15.8% vs 0.0%, P=0.001). EBV and ANA positivity rates were higher in boys than in girls. In adults, the recurrence rate was significantly higher in women than in men (18.2% vs 0.0%, P=0.005). ANA positivity rates were higher in women than in men. Conclusion: The clinical features, laboratory findings, and recurrence of KFD may differ depending on age and sex. Clinicians should be aware of this.

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Section: Discussionsupporting

confidence: 69%

Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age

Kim¹,

Jo²,

Kim³

2021

Preprint

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“…However, the diagnostic accuracy of FNAC is not high for KFD. In previous studies, the initial diagnostic accuracies of FNAC in diagnosing KFD vary, ranging from 10% to 75% 7,9‐11,17 . Diagnosing KFD using FNAC is challenging because plasmacytoid monocytes are not identified confidently in the FNAC smears 9 and crescentic histiocytes can be observed in a wide variety of lymphadenopathy, such as tuberculosis lymphadenitis and non‐Hodgkin's lymphomas 10 .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Ultrasound‐Guided Needle Biopsy in the Diagnosis of Kikuchi‐Fujimoto Disease

et al. 2020

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Objectives/Hypothesis Ultrasound‐guided fine‐needle aspiration cytology (US‐FNAC) is a well‐established procedure performed to establish the diagnosis of Kikuchi‐Fujimoto disease (KFD). Ultrasound‐guided core needle biopsy (US‐CNB) is an alternative diagnostic tool for KFD. However, the efficacy of US‐CNB is not well evaluated. This study aimed to evaluate the efficacy of US‐CNB and compare it with that of US‐FNAC in the diagnosis of KFD. Study Design Retrospective cohort study. Methods We analyzed 170 patients who were diagnosed with KFD between January 2009 and May 2019. US‐FNAC, US‐CNB, and excisional biopsy were performed in 47, 114, and 9 patients, respectively. Diagnostic accuracies of US‐FNAC and US‐CNB were analyzed and compared. Results Of the 170 patients, 45 and 125 were men and women, respectively. The mean age was 26.9 ± 9.1 years. The most common symptom was cervical lymphadenopathy, followed by fever, headache, and myalgia. The diagnosis of KFD was established primarily by US‐FNAC in 21 (44.7%) of the 47 patients, by US‐CNB in 109 (95.6%) of the 114 patients, and by excisional biopsy in all 9 patients. There was no specific major complication related to US‐FNAC and US‐CNB. Conclusion US‐CNB can be considered safe and effective and used as the primary modality for the pathological diagnosis of KFD. Level of Evidence 4. Laryngoscope, 131:E1519–E1523, 2021

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“…18,19 KFD is a type of cervical lymphadenitis that occurs rarely in children. 21 KFD is rarely reported in children and an misdiagnosed as reactive lymphoid hyperplasia or malignancy clinically and pathologically also. 1,4,22 Most of clinical diagnosis in our study was that of tuberculous lymphadenitis and reactive lymphoid hyperplasia.…”

Section: Discussionmentioning

confidence: 99%

Kikuchi-Fujimoto disease on aspiration cytology: diagnostic dilemma and clinicopathologial correlation – A retrospective study in a tertiary care hospital

Dixit¹,

S²,

P³

et al. 2019

ACHR

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Kikuchi -Fujimoto disease (KFD), also known as Histiocytic necrotizing lymphadenitis is a benign, uncommon, self-limited disease of unknown etiology. Young females are primarily affected and it manifests primarily as cervical lymphadenopathy with tenderness at times. Kikuchi and Fujimoto, way back in 1972, reported it from Japan, independently and simultaneously, as a type of lymphadenitis associated with numerous histiocytes and extensive nuclear debris. The present study aims to study the key cytomorphological features of KFD along with its clinicopathological correlation. Materials and Methods: This present study was carried out in a tertiary care hospital for a period of one year. The cases that were diagnosed as KFD on Fine needle aspiration cytology (FNAC) and whose follow up histopathology was confirmatory were included in the present study. Papanicolaou stain (PAP stain), Hematoxylin and eosin stain (H&E), and May-Grunwald Giemsa stain (MGG stain) was done on smears. Following cytological features were evaluated; cellularity, crescentic histiocytes, plasmocytoid monocytes, karyorrhectic debris and intra and extra cytoplasm apoptotic bodies. Result: Females in the age group of 31-40 years were most commonly affected with cervical lymphadenopathy as the presenting feature. The most common clinical diagnosis rendered by clinicians was tuberculosis. Karyorrhexis, crescentic histiocytes and plasmacytoid monocytes were the key cytological features. Conclusion:This study emphasizes on the key cytological features of the rare entity of KFD and its clinicopathological correlation. Knowledge and timely diagnosis of this rare entity avoids unnecessary surgical intervention and helps in timely management.

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Kikuchi-Fujimoto disease in fine needle aspiration smears: A clinico-cytologic study of 18 pediatric cases and correlation with 68 adult patients

Abstract: Besides observation and interpretation errors, a significant difference between the two groups in respect of some clinico-cytomorphological features could have influenced the routine cytodiagnosis leading to lower pickup rate of pediatric KFD cases as compared to adults.

Cited by 8 publications

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Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age

Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age

Efficacy of Ultrasound‐Guided Needle Biopsy in the Diagnosis of Kikuchi‐Fujimoto Disease

Kikuchi-Fujimoto disease on aspiration cytology: diagnostic dilemma and clinicopathologial correlation – A retrospective study in a tertiary care hospital

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