Kikuchi-Fujimoto Disease in an Atypical Site

Fernández, María Ramos; Hiscock, Luis Jiménez; Navarro, Beatriz de Olaiz

doi:10.1016/s1579-2129(09)72441-3

Cited by 5 publications

(6 citation statements)

References 7 publications

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“…Lee et al (4) reported increased uptake on PET in the right cervical parotid space, bilateral upper to lower cervical, supraclavicular, axillary, intra-abdominal, and retroperitoneal regions (4). Another case with no evidence of cervical or supraclavicular adenopathy was reported recently by Fernández et al (5), in which CT showed not only enlarged mediastinal and subcarinal lymph nodes but also small peripherally distributed subpleural nodules.…”

Section: Discussionmentioning

confidence: 93%

“…The presenting symptoms are high fever and cervical adenopathy, with pathological findings of histiocytic necrotizing lymphadenitis (1,2). Several authors have reported cases with lymphadenopathy in an atypical location, and such cases are difficult to differentiate from malignant lymphoma (3)(4)(5)(6). A biopsy is necessary to arrive at a final histological diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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Mediastinal Lymphadenopathy without Cervical Lymphadenopathy in a Case of Kikuchi- Fujimoto Disease

et al. 2011

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A 44-year-old man was referred to our hospital because of persistent high fever. Both CT and PET-CT demonstrated lymph node lesions limited to the mediastinal region without cervical lymphadenopathy. Histology of a mediastinal lymph node obtained by video-assisted thoroscopic excision confirmed the diagnosis of histiocytic necrotizing lymphadenitis. To our knowledge, this is the first report of Kikuchi-Fujimoto disease with isolated mediastinal lymphadenopathy. Although Kikuchi-Fujimoto disease is rare, we should consider this disease in patients with a high fever and no other symptoms.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Mediastinal Lymphadenopathy without Cervical Lymphadenopathy in a Case of Kikuchi- Fujimoto Disease

et al. 2011

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“…In this case, all symptoms resolved after using steroids. Another case with no evidence of cervical or supraclavicular adenopathy was reported recently by Fernández et al, in which CT showed not only enlarged mediastinal and subcarinal lymph nodes but also small peripherally distributed subpleural nodules [15].…”

Section: Discussionmentioning

confidence: 83%

“…Kikuchi Fujimoto disease most often occurs in the lymph nodes of the neck, but it has been also described in other locations: cervical parotid space, suparaclavicular, axillary, intra-abdominal, and retroperitoneal regions [9,14,15,16]. There are a few cases of chest location.…”

Section: Discussionmentioning

confidence: 99%

Quiz. Correct answer to the quiz. Check your diagnosis Histiocytic necrotising lymphadenitis in mediastinum mimicking thymoma or lymphoma – case presentation and literature review of Kikuchi Fujimoto disease

Błasiak

Jeleń²,

Rzechonek³

et al. 2016

pjp

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Kikuchi Fujimoto disease (KFD) as a rare self-limiting lymphadenopathy of short and benign course concerns most frequently the lymph nodes of the neck. The most common symptoms are painfulness of the diseased area, fever and night sweating. The etiology is not well understood, but in the role of pathogenesis viral, autoimmune and genetic factors are taken into account. In the presented case of 37-year-old female it was necessary to exclude diseases such as lymphoma or thymoma because of atypical mediastinal location of Kikuchi Fujimoto disease. After multidisciplinary consultation the lymph node was resected from the mediastinum with videothoracoscopic approach. The diagnosis was difficult for the pathologist because of the large percentage of necrosis of the lymph node but the image was typical for histiocytic necrotizing lymphadenitis. Two cases of patients with KFD limited to the mediastinum have been previously reported in the literature. This article presents the world's first reported case of this disease in the topographic location of the thymus. Furthermore, a review of current literature was made.

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“…Deep sites of lymphadenopathy are mentioned in the literature, such as mediastinal lymphadenopathy, intraabdominal lymphadenopathy, hepatomegaly, and splenomegaly. [12][13][14][15] No specific laboratory test can be used to diagnose KFD. There are many nonspecific laboratory findings in KFD patients, such as leukopenia, lymphopenia, thrombocytopenia, and elevated alanine aminotransferase, an elevated erythrocyte sedimentation rate, elevated C-reactive protein, and elevated lactate dehydrogenase levels.…”

Section: Discussionmentioning

confidence: 99%

The Differential Diagnosis of Bilateral Pleural Effusion and Multiple Mediastinal Lymphadenopathies Includes Kikuchi-Fujimoto Disease

Huang

2020

Journal of Investigative Medicine High Impact Case Reports

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Kikuchi-Fujimoto disease is an uncommon lymphohistiocytic disorder that frequently presents with acute or subacute clinical disease course. Cervical lymphadenopathy is the most common involved lymph node. Very rare cases of pathologic diagnosis of Kikuchi-Fujimoto disease with bilateral pleural effusion and multiple mediastinal lymphadenopathies have been reported in the literature. In this article, we report the case of a 60-year-old male presented with bilateral pleural effusion and multiple mediastinal lymphadenopathies. He received video-assisted thoracoscopic surgery of the right pleura and thoracoscopic excision of the mediastinal lymph node. The pathologic findings from the lymph node and pleura were compatible with Kikuchi-Fujimoto disease. He was treated with oral hydroxychloroquine and oral prednisolone. A computed tomography scan of the chest 4 months later showed regressive mediastinal lymphadenopathy and bilateral pleural effusion. Our case is a first reported case of Kikuchi-Fujimoto disease diagnosis by the pathology of the lymph node and pleura in the literature. Results from our case suggest that Kikuchi-Fujimoto disease should be included in the differential diagnosis of bilateral pleural effusion and multiple mediastinal lymphadenopathies.

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Kikuchi-Fujimoto Disease in an Atypical Site

Cited by 5 publications

References 7 publications

Mediastinal Lymphadenopathy without Cervical Lymphadenopathy in a Case of Kikuchi- Fujimoto Disease

Mediastinal Lymphadenopathy without Cervical Lymphadenopathy in a Case of Kikuchi- Fujimoto Disease

Quiz. Correct answer to the quiz. Check your diagnosis Histiocytic necrotising lymphadenitis in mediastinum mimicking thymoma or lymphoma – case presentation and literature review of Kikuchi Fujimoto disease

The Differential Diagnosis of Bilateral Pleural Effusion and Multiple Mediastinal Lymphadenopathies Includes Kikuchi-Fujimoto Disease

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