Kikuchi-Fujimoto Disease in an Adolescent Boy

Cellura, A; Gallitano, Stephanie M.; McDermott, Laura E.; Shantharam, Rohini; Finelt, Nika; Chen, Sheng

doi:10.12788/cutis.0369

Cited by 2 publications

(4 citation statements)

References 11 publications

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“…They showed an incidence of 0.6% and 1.16% KFD out of 2500 and 1884 lymphoid tissue biopsies, respectively. Since this illness is rare and the etiology behind it is not well comprehended, many case reports suggested a relation between this disease and developing an autoimmune disease such as Sjogren's syndrome, Hashimoto's thyroiditis, and pseudoappendicitis [9][10][11][12][13]. In addition, there are some hypothesized etiologies including viral infections such as EBV, parvovirus B-19, HHV8, human herpesvirus 6, and CMV [11][12][13][14].…”

Section: Discussionmentioning

confidence: 99%

“…Since this illness is rare and the etiology behind it is not well comprehended, many case reports suggested a relation between this disease and developing an autoimmune disease such as Sjogren's syndrome, Hashimoto's thyroiditis, and pseudoappendicitis [9][10][11][12][13]. In addition, there are some hypothesized etiologies including viral infections such as EBV, parvovirus B-19, HHV8, human herpesvirus 6, and CMV [11][12][13][14]. Moreover, KFD has been linked with antiphospholipid syndrome, polymyositis, bilateral uveitis, peripheral arthritis, cutaneous necrotizing vasculitis, and pulmonary hemorrhage [15].…”

Section: Discussionmentioning

confidence: 99%

“…It is known that KFD can be associated with other medical illnesses -like viral infection, autoimmune diseases, and malignancy -or idiopathic [9][10][11][12][13][14][15][16][17]. Most of our cases are idiopathic (56.7%) and 43.3% show association with predominantly autoimmune diseases and less commonly viral infection.…”

Section: Discussionmentioning

confidence: 99%

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Pathological Features and Clinical Characteristics of Kikuchi-Fujimoto Disease: A Tertiary Hospital Experience in Riyadh, Saudi Arabia

Alshieban

Masuadi

Alghamdi

et al. 2023

Cureus

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BackgroundKikuchi-Fujimoto disease (KFD) -also known as necrotizing histiocytic lymphadenitis -is a benign histiocytic lymphadenitis known for its low incidence and misdiagnosis that occurs mostly in young Asian females more than males. This disease resolves spontaneously in a few months with a low risk of relapse (one in 30 patients) after resolution. ObjectivesThe aim of this study is to share King Abdulaziz Medical City's (KAMC's) experience with KFD by determining its clinicopathological characteristics. Materials and methodsIn this study, we reviewed histopathological slides and pathological reports of all lymphadenopathy cases (683 cases) in the period between January 2008 and December 2018. ResultsForty-four cases of KFD were found and their clinicopathological characteristics were recorded. There is a slight female predominance (59% females versus 41% males) with a wide age range from 10 months to 97 years (mean = 28.8). The majority of the cases (63.6%) are seen in young adults (between 21 and 40 years). Association with autoimmune diseases was shown by 20.5% of cases while viral infection association was shown by few cases. Most cases showed remission (59%) and no deaths were reported upon follow-up. Histopathologically, the majority of cases have proliferative type followed by the necrotic type and few cases showed xanthomatous type. ConclusionsOur study has the largest number of KFD cases in this region. It is obvious that KFD has clinical, radiological, and pathological features that overlap with malignancy, especially lymphoma. Knowing this disease and careful diagnostic approach can help avoid misdiagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pathological Features and Clinical Characteristics of Kikuchi-Fujimoto Disease: A Tertiary Hospital Experience in Riyadh, Saudi Arabia

Alshieban

Masuadi

Alghamdi

et al. 2023

Cureus

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“…The treatment is aimed at symptomatic control, and non-steroidal anti-inflammatory drugs (NSAIDs) have been recommended for lymph node sensitivity or febrile illness (Cellura et al, 2021). If it is severe, the use of glucocorticoids has been recommended, but there is no agreement among experts on the dosage or duration (Dumas et al, 2014;Jang et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Kikuchi Fujimoto's Disease: A Strange Cause of Cervical Lymphadenopathy, As A Differential Diagnosis of Nodal Tuberculosis: A Case Report in A Public Hospital - Peru

Vásquez Becerra,

Quiroz-Zela,

Ballesteros-Patiño

et al. 2023

FMCR

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Kikuchi-Fujimoto disease is a rare cause of lymphadenopathy of unknown etiology to date. Its clinical manifestations are the presence of lymphadenopathies associated with fever, diaphoresis, and night sweats. The diagnosis is made by histopathology and the exclusion of other pathologies, and its management is symptomatic. A case is reported of a 26-year-old woman from Venezuela, from the district of San Juan de Miraflores, department of Lima - Peru, who presented with an increase in the volume of the cervical lymph node in 3 months, very painful associated with night sweats. The diagnosis was established by the anamnesis, clinical picture, laboratory tests, and pathological anatomy; she received symptomatic treatment with a favorable evolution. The clinical, laboratory, and therapeutic aspects of the disease are discussed.

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Kikuchi-Fujimoto Disease in an Adolescent Boy

Cited by 2 publications

References 11 publications

Pathological Features and Clinical Characteristics of Kikuchi-Fujimoto Disease: A Tertiary Hospital Experience in Riyadh, Saudi Arabia

Pathological Features and Clinical Characteristics of Kikuchi-Fujimoto Disease: A Tertiary Hospital Experience in Riyadh, Saudi Arabia

Kikuchi Fujimoto's Disease: A Strange Cause of Cervical Lymphadenopathy, As A Differential Diagnosis of Nodal Tuberculosis: A Case Report in A Public Hospital - Peru

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