Kikuchi-Fujimoto Disease and Systemic Lupus Erythematosus: The EBV Connection?

Gionanlis, Lazaros; Katsounaros, Marios; Bamihas, Gerasimos; Fragidis, S.; Veneti, Panagiota; Sombolos, Kostas

doi:10.1080/08860220802595518

Cited by 14 publications

(9 citation statements)

References 15 publications

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“…La asociación entre enfermedad autoinmunes, específicamente lupus eritematoso sistémico y Kikuchi-Fujimoto ha sido reportada en varios artículos a nivel mundial (6)(7)(8). La enfermedad de Kikuchi-Fujimoto puede presentarse antes, después o superpuesta con el lupus eritematoso sistémico (9,10).…”

Section: Discussionunclassified

Una relación potencialmente peligrosa: lupus eritematoso sistémico y enfermedad de Kikuchi – Fujimoto

Botero-Echeverri¹,

Muriel-Hurtado²,

Arteta-Cueto³

2016

CES Med

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Comparte ResumenLa enfermedad de Kikuchi-Fujimoto (EKF) es conocida como una linfadenitis necrotizante histiocítica, tiene una presentación benigna y autolimitada, afecta principalmente a mujeres jóvenes y generalmente resuelve sin tratamiento en los primeros seis meses de los síntomas. Presentamos el caso de una mujer de 48 años quien consultó por un cuadro de dolor abdominal, mialgias y adenopatía cervical al examen físico. Se le encontró en los exámenes paraclínicos anticuerpos antinucleares 1:640, anti DNA de doble cadena asociado a consumo de complemento y anticuerpos anticardiolipina positivos. Se realizó biopsia de ganglio cervical que mostró necrosis cortical y población de histiocitos y linfocitos. Al iniciar el manejo con esteroides y cloroquina se comprobó mejoría franca y posteriormente la paciente fue dada de alta, continuando controles de manera ambulatoria por los servicios de reumatología y medicina interna.Palabras clave: Enfermedad de Kikuchi-Fujimoto, Linfadenitis necrotizante, Lupus eritematoso sistémico. AbstractKikuchi disease, also known as histiocytic necrotizing lymphadenitis, isa benign and self-limited condition that mainly affects young women andresolve without treatment within six months of symptoms. It was first describedin Japan in 1972 and is more common in Asian population. We report the case of a woman of 48 years who consults for abdominal pain, myalgia, and cervical lymphadenopathy on physical examination. He found himself in the presence of antinuclear antibodies paraclinical 1: 640 positive DNA double chain associated with complement consumption and positive cardiolipin antibodies We perform cervical node biopsy that showed the presence of cortical necrosis and histiocytes and lymphocytes population. When you start handling steroid and chloroquine, a high frank and subsequent improvement was observed, continuing control rheumatology and internal medicine.

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Section: Discussionunclassified

Una relación potencialmente peligrosa: lupus eritematoso sistémico y enfermedad de Kikuchi – Fujimoto

Botero-Echeverri¹,

Muriel-Hurtado²,

Arteta-Cueto³

2016

CES Med

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“…The nodes are firm in consistency and may be tender. In 30%–50% of patients, fever is the presenting symptom [4, 6]. Other symptoms and signs include splenomegaly, weight loss, arthralgia, and skin rash.…”

Section: Discussionmentioning

confidence: 99%

Kikuchi-Fujimoto Disease Associated with Myasthenia Gravis: A Case Report

Onasanya

Nochlin

Casas

et al. 2010

Case Reports in Medicine

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Kikuchi-Fujimoto disease is a self-limited benign condition of unknown etiology characterized by cervical lymphadenopathy, fever, and leucopenia. An autoimmune hypothesis has been suggested and an association with systemic lupus erythematosus, Sjogren's disease, and antiphospholipid syndrome has been noted. We report a 27-year-old male who presented for evaluation of weakness and he was diagnosed with seropositive generalized myasthenia gravis and underwent a thymectomy. He was stable until five months post-thymectomy, when he developed a high fever associated with nontender cervical lymphadenopathy, chills, and night sweats. Histopathology of a cervical lymph gland biopsy was compatible with Kikuchi-Fujimoto lymphadenitis. He improved spontaneously and was asymptomatic at the followup six months later. Our case expands the association of Kikuchi-Fujimoto disease with autoimmune disorders to include myasthenia gravis.

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“…The diagnosis is established by identifying characteristic pathologic features from a lymph node biopsy: paracortical necrosis with karyorrhectic foci of histiocytes, plasmacytoid monocytes, immunoblasts, and small and large lymphocytes with a predominance of CD8+ T cells. Pathological examination enables HNL to be differentiated from other types of necrotizing lymphadenitis, such as SLE, malignant lymphoma or pyogenic infections [1,4]. …”

Section: Case Presentationmentioning

confidence: 99%

“…A short course of steroid therapy may be indicated if HNL is very symptomatic. However, patients must be followed-up over the long term because SLE can develop several years after the diagnosis of HNL [4]. …”

Section: Case Presentationmentioning

confidence: 99%

Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease) after laparoscopic Roux-en-Y gastric bypass for morbid obesity: a case report

et al. 2012

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IntroductionKikuchi-Fujimoto disease, or histiocytic necrotizing lymphadenitis, is a rare, benign, autoimmune condition characterized by lymphadenopathy, fever and neutropenia. It is a self-limited condition of unknown etiology.Case presentationWe report the case of a 45-year-old Caucasian man with the first known case of Kikuchi disease associated with dramatic weight loss after bariatric surgery.ConclusionAlthough the association between Kikuchi disease and bariatric surgery may be entirely coincidental, we speculate whether the immune dysfunction associated with weight loss may have played an etiologic role in this process.

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Kikuchi-Fujimoto Disease and Systemic Lupus Erythematosus: The EBV Connection?

Cited by 14 publications

References 15 publications

Una relación potencialmente peligrosa: lupus eritematoso sistémico y enfermedad de Kikuchi – Fujimoto

Una relación potencialmente peligrosa: lupus eritematoso sistémico y enfermedad de Kikuchi – Fujimoto

Kikuchi-Fujimoto Disease Associated with Myasthenia Gravis: A Case Report

Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease) after laparoscopic Roux-en-Y gastric bypass for morbid obesity: a case report

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