Kikuchi–Fujimoto Disease and Prognostic Implications

Salamat, Sebastian; Chan, Jacqueline; Jolly, Karan; Powell, Gail; Harrison, Katherine; Ahanger, Sajad; Hari, Churunal

doi:10.1007/s12105-019-01026-0

Cited by 15 publications

(40 citation statements)

References 15 publications

(18 reference statements)

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“…One 22 year old male patient in this study presented with symptoms of cervical lymphadenopathy for The histopathology findings of the excisional lymph node biopsy remains gold standard for confirming Kikuchi's disease. In this study, the findings were sub grouped into 3 morphological phases as done in previous studies 5,7,8 , and a vast majority of the confirmed cases presented in proliferative phase of KFD (n = 40, 59.7%).…”

Section: Resultsmentioning

confidence: 99%

“…Clinically and histologically, the disease is often misdiagnosed as tuberculosis, lymphoma or systemic lupus erythematosus (SLE) 4 . KFD can be seen in patients with previous history of SLE, it can coexist with SLE or complicate into SLE 7 .This association with SLE was more common in Asian than European patients 6 . Meanwhile, a significant number of patients were found to have underlying viral infections 6 .…”

Section: Introductionmentioning

confidence: 96%

“…The gold standard investigation for diagnosis is by histopathological examination of an excisional biopsy obtained from the affected lymph node 7 . Histologically, altered lymph node architecture by nodules in the cortex, and apoptotic cells with areas of necrosis accumulation of crescentic histiocytic, and the absence of eosinophils and basophils are typical fine-needle aspiration cytology features seen in KFD 6,8 .…”

Section: Introductionmentioning

confidence: 99%

“…Due to challenges faced in diagnosing KFD, three evolving histologic patterns have been proposed by pathologists based on key morphologic features. Namely, they are proliferative, necrotizing and xanthomatous 7 . Most patients have normal laboratory findings 1 .…”

Section: Introductionmentioning

confidence: 99%

“…Even though, this disease almost always runs a benign course and resolves in several weeks to months in most patients 6,9 , it is seen to increase the risk of SLE and lymphoma 7 . Treatment if necessary is symptomatic with analgesics and antipyretics 1 .…”

Section: Introductionmentioning

confidence: 99%

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Kikuchi-Fujimoto Disease: A Study Of 67 Cases From Coastal South India 

Achappa¹,

Herath²,

Kini³

et al. 2020

Preprint

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Background Kikuchi-Fujimoto disease is a rare, benign condition, of unknown etiology, presenting as cervical lymphadenitis, usually tender and maybe associated with systemic symptoms. Despite the extensive literature on this disease, it continues to be misdiagnosed owing to its misleading clinical presentation. Results The mean age in our study was 26.9 (±11.3) years with a female majority of 65.7%. The clinical presentation of most cases was, tender swelling over the side of the neck ( n =50, 74.6%). On local examination, the mean length and width were 2.3 (±1.0) cm and 2.2 (±0.7) cm respectively. Histopathological examination revealed that most patients presented in the proliferative stage ( n =40, 59.7%). In 83.6% of the patients lymphadenopathy resolved in less than 2 months. Follow up of these patients over 9 months revealed that a vast majority of the patients underwent full recovery with symptomatic treatment ( n =42, 62.7%). Conclusions The disease is prevalent in young, female patients of Asian descent and often presents as cervical lymphadenopathy. Early diagnosis with excisional lymph node biopsy is crucial to avoid unnecessary investigations and treatment. Treatment is only symptomatic unless complicated, where steroid therapy is considered. Kikuchi’s disease has an excellent prognosis with almost no risk of fatality.

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Section: Resultsmentioning

confidence: 99%