Kikuchi‐Fujimoto Disease: A Case Report

Lee, Chih‐Hung; Cheng, Shih‐Tsung

doi:10.1016/s1607-551x(09)70432-2

Cited by 6 publications

(5 citation statements)

References 25 publications

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“…In many instances, Kikuchi disease is a self-limiting disorder that regresses spontaneously in 1–4 months with symptomatic management with antipyretics and analgesics. Unresponsive cases need to be treated with systemic corticosteroids to aid in early recovery [ 21 ]. Hydroxychloroquine and intravenous immunoglobulins are some of the specific therapeutic options which have been used with successful outcomes [ 22 – 24 ].…”

Section: Discussionmentioning

confidence: 99%

Kikuchi disease complicated with aseptic meningitis following COVID-19 Vaccination: a case report

Kularathna,

Medagama,

Bandara

et al. 2024

J Med Case Reports

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Background Kikuchi Fujimoto disease is a rare self-limiting disorder mainly affecting young Asian females. The typical presentation is unexplained fever with associated cervical lymphadenopathy. It can mimic many sinister diseases such as lymphoma, tuberculosis, and systemic lupus erythematosus. Aseptic meningitis due to Kikuchi disease is extremely rare, and majority were reported from Japan. There have been no published cases of aseptic meningitis due to Kikuchi disease in Sri Lanka. Case presentation A 29 years old Sri Lankan female presented with a prolonged fever for three weeks with an associated headache for five days duration. She developed painful cervical lymphadenopathy during the hospital stay. She has been previously well and had been vaccinated against COVID-19 six weeks before. Her lumbar puncture showed lymphocytic pleocytosis with marginally elevated protein levels and reduced ratio of serum to CSF sugar. Lymph node biopsy was consistent with necrotizing lymphadenitis. She was subsequently diagnosed with Kikuchi disease complicated with aseptic meningitis. She responded to corticosteroids well and had an uneventful recovery. Conclusion Kikuchi disease is a rare self-limiting disorder that can be complicated with aseptic meningitis on infrequent occasions. Other conditions such as tuberculosis, lymphoma, systemic lupus erythematosus, and adult-onset Still’s disease should be considered as differential diagnoses. Knowledge of Kikuchi disease and its complications will prevent unnecessary investigations which delay the early diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

Kikuchi disease complicated with aseptic meningitis following COVID-19 Vaccination: a case report

Kularathna,

Medagama,

Bandara

et al. 2024

J Med Case Reports

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“…suggested that KFD and systemic lupus erythematosus (SLE) have in common a hyperimmune reaction, which later is expressed as two different manifestations: one compromising lymph nodes (KFD), and the other manifesting as SLE. Thus, diagnosing KFD can be challenging given the similarities between KFD-lymphadenopathy and other autoimmune-lymphadenopathies and that KFD is not a well-known entity among clinicians and pathologists 8 , 9 .…”

Section: Discussionmentioning

confidence: 99%

Activated phosphoinositide 3-kinase delta syndrome 2 associated with Kikuchi–Fujimoto disease: a rare Palestinian case report

Abulaila

Sabha

Misk

et al. 2023

Annals of Medicine &Amp; Surgery

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Introduction: Histiocytic necrotic lymphadenitis (HNL), also known as Kikuchi–Fujimoto disease (KFD), is a rare local lymphadenopathy with a benign course and clinical manifestations such as fever, lymphadenopathy, rash, hepatosplenomegaly, central nervous system (CNS) symptoms, and hemophilic cell syndrome. It was first identified by Japanese pathologists Kikuchi and Fujimoto. KFD damages the meninges, the brain parenchyma, and peripheral nerves in addition to the CNS. Neurological symptoms may even be the most obvious clinical manifestations or initial symptoms of the disease. Case presentation: We present a unique case of a 7-year-old male patient who was diagnosed with activated phosphoinositide 3-kinase delta syndrome 2 (APDS 2) associated with KFD, a HNL during a workup for fever without a focus and cervical lymphadenopathy. Conclusion: Highlighted the unique relationship between two uncommon conditions and stressed the significance of adding KFD to the list of possible diagnoses for lymphadenopathy in APDS 2. Furthermore, we demonstrate that patients with APDS 2 may exhibit low immunoglobulin M levels.

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“…A definitive diagnosis of KFD can be made only by histological examination of the affected node; diagnostic imaging studies (chest radiography, ultrasound, CT scanning or MR imaging) confirm the presence of enlarged lymph nodes in the affected areas but cannot specifically confirm a diagnosis of KFD [31]. Node extirpation is appropriate, as the findings of fine needle aspiration are most often nonspecific [5]. Morphologically, the lesion affects the cortical and paracortical areas of the node with single or multiple necrotic foci.…”

Section: Discussionmentioning

confidence: 99%

“…Although its pathogenesis remains unclear, it is assumed that the disease results from a genetic predisposition with a consecutive hyperimmune reaction to various agents or an autoimmune reaction with lymphocyte apoptosis as a key factor [5]. The aim of this report is to increase awareness of the possibility of KFD since this disease can easily be mistaken for lymphoma or systemic lupus erythematosus (SLE) and thus patients might be overtreated.…”

Section: Introductionmentioning

confidence: 99%

Necrotizing cervical lymphadenopathy: Kikuchi-Fujimoto disease in a young male

Glaser

Borin

Kavalar

et al. 2008

Wien Klin Wochenschr

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Kikuchi-Fujimoto disease (KFD) or histiocytic necrotizing lymphadenitis is a rare benign disease, more common in Japanese women, with only a few cases reported from other parts of the world. The pathogenesis is poorly understood. A 22-year-old man noticed a node growth a month before his admittance. At first he noticed one enlarged node in the left axilla, later also the nodes on his neck and in his right axilla. Before that he had felt shivery and reported night sweats. Physical examination revealed bilateral enlarged (up to 2 cm) painful but not inflamed lymph nodes on the neck and in both axillae. The patient was diagnosed with KFD on histological examination of the nodes and on the basis of typical changes. No medical treatment was prescribed and the patient has been without symptoms for the past two years. The clinical picture of KFD is nonspecific and variable. Most patients complain of enlarged cervical nodes (up to 2 cm) accompanied by various symptoms (fever, malaise, night sweats, weight loss). The enlarged nodes, which are mobile, rarely appear in other locations. The only way of proving whether the disease is present or not is by histological examination of the node, which may show the following changes typical for KFD: paracortical necrotic foci, surrounded by histiocytic aggregates, irregular rounded eosinophilic areas of different sizes in the paracortex and cortex with the presence of numerous histiocytes, lymphocytes, immunoblasts, plasmacytoid monocytes and eosinophilic granulated cellular debris. Histiocytes had mostly turned into foamy macrophages. It is typical not to find epithelioid cells and neutrophil granulocytes in the necrotic centers. In particular, the disease needs to be distinguished from high-grade lymphoma and SLE lymphadenitis. There is no specific medical treatment for KFD since the disease usually resolves spontaneously over four months. Disease recurrence or fatalities are unusual.

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Kikuchi‐Fujimoto Disease: A Case Report

Cited by 6 publications

References 25 publications

Kikuchi disease complicated with aseptic meningitis following COVID-19 Vaccination: a case report

Kikuchi disease complicated with aseptic meningitis following COVID-19 Vaccination: a case report

Activated phosphoinositide 3-kinase delta syndrome 2 associated with Kikuchi–Fujimoto disease: a rare Palestinian case report

Necrotizing cervical lymphadenopathy: Kikuchi-Fujimoto disease in a young male

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