Kikuchi Disease: A Clinicopathological Analysis of 13 Cases from Riyadh Central Hospital

Abba, Abdullah A.; Afzal, Mohammed; Al-Moharab, Fahad I.; Baez-Giangreco, Atilio

doi:10.5144/0256-4947.1995.288

Cited by 4 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, we reported 44 cases of KFD after excluding SLE cases as they show almost similar histopathological findings; however, they have distinctive clinical course, management, and outcome. We found a 6.4% incidence compared to 0.6% and 1.16% reported in Abba A et al in 1995 and Al-Maghrabi J et al in 2005 [7,9]. The increased risk may be related to the awareness of healthcare providers about the disease and the availability of diagnostic tools like immunohistochemistry.…”

Section: Discussioncontrasting

confidence: 40%

“…In Saudi Arabia, around 11 studies and case reports were conducted exploring the clinicopathological characteristics of KFD. Two studies (Abba A et al in 1995 andAl-Maghrabi J et al in 2005) were done on a large scale [7,8]. They showed an incidence of 0.6% and 1.16% KFD out of 2500 and 1884 lymphoid tissue biopsies, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…It is obvious that KFD has clinical, radiological, and pathological features that overlap with malignancy, especially lymphoma. Knowing this disease and careful diagnostic approach can help avoid misdiagnosis [7].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Pathological Features and Clinical Characteristics of Kikuchi-Fujimoto Disease: A Tertiary Hospital Experience in Riyadh, Saudi Arabia

Alshieban

Masuadi

Alghamdi

et al. 2023

Cureus

View full text Add to dashboard Cite

BackgroundKikuchi-Fujimoto disease (KFD) -also known as necrotizing histiocytic lymphadenitis -is a benign histiocytic lymphadenitis known for its low incidence and misdiagnosis that occurs mostly in young Asian females more than males. This disease resolves spontaneously in a few months with a low risk of relapse (one in 30 patients) after resolution. ObjectivesThe aim of this study is to share King Abdulaziz Medical City's (KAMC's) experience with KFD by determining its clinicopathological characteristics. Materials and methodsIn this study, we reviewed histopathological slides and pathological reports of all lymphadenopathy cases (683 cases) in the period between January 2008 and December 2018. ResultsForty-four cases of KFD were found and their clinicopathological characteristics were recorded. There is a slight female predominance (59% females versus 41% males) with a wide age range from 10 months to 97 years (mean = 28.8). The majority of the cases (63.6%) are seen in young adults (between 21 and 40 years). Association with autoimmune diseases was shown by 20.5% of cases while viral infection association was shown by few cases. Most cases showed remission (59%) and no deaths were reported upon follow-up. Histopathologically, the majority of cases have proliferative type followed by the necrotic type and few cases showed xanthomatous type. ConclusionsOur study has the largest number of KFD cases in this region. It is obvious that KFD has clinical, radiological, and pathological features that overlap with malignancy, especially lymphoma. Knowing this disease and careful diagnostic approach can help avoid misdiagnosis.

show abstract

Section: Discussioncontrasting

confidence: 40%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pathological Features and Clinical Characteristics of Kikuchi-Fujimoto Disease: A Tertiary Hospital Experience in Riyadh, Saudi Arabia

Alshieban

Masuadi

Alghamdi

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…Kikuchi's disease (KD) also known as Kikuchi-Fujimoto disease (KFD), or histiocytic necrotizing lymphadenitis was first described in 1972 independently by Kikuchi and Fujimoto et al [1] , [2] . Initially all reports of Kikuchi-Fujimoto disease came from Japan but subsequently it has been reported from Europe, America, Asia and Middle East [3] , [4] , [5] , [6] , [7] . Kikuchi-Fujimoto disease is a benign self-limited condition of unknown etiology which usually presents with cervical lymphadenopathy or fever of unknown origin [8] .…”

Section: Discussionmentioning

confidence: 99%

Kikuchi-Fujimoto disease following SARS CoV2 vaccination: Case report

Soub

Ibrahim

Maslamani

et al. 2021

IDCases

View full text Add to dashboard Cite

Kikuchi's disease (KD) also known as Kikuchi-Fujimoto disease (KFD), or histiocytic necrotizing lymphadenitis was first described in 1972 independently by Kikuchi and Fujimoto et al. It is a benign self-limited condition of unknown etiology which usually presents with cervical lymphadenopathy or fever of unknown origin. The diagnosis of KFD is based on histopathologic examination of the involved lymph node, showing the presence of well-defined necrosis without granulocytic cells. There is no special treatment for KFD. However non-steroidal anti-inflammatory drugs or corticosteroids are required occasionally to control the associated systemic manifestations. The outcome of the disease is usually favorable with resolution of symptoms in most cases within one to four months. We report a case of Kikuchi-Fujimoto disease that occurred in a young Qatari male patient 10 days following receiving the first dose of BNT162b2 vaccine. Diagnosis was established by lymph node biopsy and recovery was complete after 10 days.

show abstract

“…2 So far, 28 patients have been reported from Saudi Arabia. 6,7,9,10 The association between KD and SLE, or other autoimmune diseases, has been described in the literature, 2,6,7,14,15 where SLE appeared after the diagnosis of KD 2 or even preceded it. 8 Histologically, the disease is characterized by coagulative necrosis, an infiltrate of histiocytic cells, varying degrees of loss of nodal architecture and an absence of polymorphs.…”

Section: Discussionmentioning

confidence: 99%

Kikuchi's Disease and Systemic Lupus Erythematosus in A Saudi Child

Salloum

1998

Ann Saudi Med

View full text Add to dashboard Cite

Kikuchi Disease: A Clinicopathological Analysis of 13 Cases from Riyadh Central Hospital

Cited by 4 publications

References 11 publications

Pathological Features and Clinical Characteristics of Kikuchi-Fujimoto Disease: A Tertiary Hospital Experience in Riyadh, Saudi Arabia

Pathological Features and Clinical Characteristics of Kikuchi-Fujimoto Disease: A Tertiary Hospital Experience in Riyadh, Saudi Arabia

Kikuchi-Fujimoto disease following SARS CoV2 vaccination: Case report

Kikuchi's Disease and Systemic Lupus Erythematosus in A Saudi Child

Contact Info

Product

Resources

About