KIF23 regulation by miR-107 controls replicative tumor cell fitness in mouse and human hepatocellular carcinoma
Mirco Castoldi,
Sanchari Roy,
Carolin Lohr
et al.
Abstract:Background & AimsIn hepatocellular carcinoma, there is a lack of successful translation of experimental targets identified in mouse models to human patients. In this study, we used a comprehensive transcriptomic approach in mice to identify novel potential targets for therapeutic intervention in humans.MethodsWe analysed combined genome-wide miRNA and mRNA expression data in three pathogenically distinct mouse models of liver cancer. Effects of target genes on hepatoma cell fitness were evaluated by prolif… Show more
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