“…Early studies of different animal models demonstrated that the periodontal tissues possess some regeneration activity, suggesting the existence of stem cell population within the periodontium (Karring et al, 1980; Nielsen et al, 1980; Nyman et al, 1980, 1982; Parlar et al, 2005). After depletion of various periodontal tissues, not only the periodontal ligaments, but also cementum and alveolar bone, can be regenerated, suggesting the presence of multipotential stem cell populations (Nielsen et al, 1980; Nyman et al, 1982; Parlar et al, 2005). Studies conducted on the human periodontium indicate the presence of a putative PDLSCs population (Seo et al, 2004), positive for MSC markers including STRO-1 and CD146 and able to differentiate into osteoblasts, adipocytes, and cementoblasts (Seo et al, 2004).…”