“…Clinical (Scopp et al 1966, Older 1967) and histological (Arrocha et al 1968, Nielsen et al 1980, 1981 studies promoted the use of anorganic bovine bone for grafting in intra-osseous defects. In this context, an anorganic xenograft (Bio-Oss s , Geistlich Pharma AG, Wolhusen, Switzerland) was developed for bone regeneration procedures.…”