Kidney Tumor Location Measurement Using the C Index Method

Simmons, Matthew N.; Ching, Christina B.; Samplaski, Mary K.; Park, Chin Hyong; Gill, Inderbir S.

doi:10.1016/j.juro.2010.01.005

Cited by 340 publications

(247 citation statements)

References 4 publications

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“…Anatomical factors are reflected in the TNM classification and provide the most reliable prognostic information. In addition, objective anatomical classification systems such as the Preoperative Aspects and Dimensions Used for an Anatomical (PADUA) classification system, the RENAL nephrometry score, and the C-index have been proposed to standardise the description of renal tumours and aid in comparing nephron-sparing treatment strategies [39][40][41]. Histological factors include nuclear grade, RCC subtype, sarcomatoid features, microvascular A chest CT is recommended for staging assessment of the lungs and mediastinum C A bone scan is not routinely recommended C A renal tumour biopsy is recommended before ablative therapy and systemic therapy without previous pathology C A percutaneous biopsy is recommended in patients in whom active surveillance is pursued C A percutaneous renal tumour biopsy should be obtained with a coaxial technique C Use of the current TNM classification system is recommended.…”

Section: Prognostic Factorsmentioning

confidence: 99%

EAU Guidelines on Renal Cell Carcinoma: 2014 Update

Ljungberg¹,

Bensalah²,

Canfield³

et al. 2015

European Urology

2,675

1,914

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Context: The European Association of Urology Guideline Panel for Renal Cell Carcinoma (RCC) has prepared evidence-based guidelines and recommendations for RCC management. Objectives: To provide an update of the 2010 RCC guideline based on a standardised methodology that is robust, transparent, reproducible, and reliable. Evidence acquisition: For the 2014 update, the panel prioritised the following topics: percutaneous biopsy of renal masses, treatment of localised RCC (including surgical and nonsurgical management), lymph node dissection, management of venous thrombus, systemic therapy, and local treatment of metastases, for which evidence synthesis was undertaken based on systematic reviews adhering to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Relevant databases (Medline, Cochrane Library, trial registries, conference proceedings) were searched (January 2000 to November 2013) including randomised controlled trials (RCTs) and retrospective or controlled studies with a comparator arm. Risk of bias (RoB) assessment and qualitative and quantitative synthesis of the evidence were performed. The remaining sections of the document were updated following a structured literature assessment. Evidence synthesis: All chapters of the RCC guideline were updated. For the various systematic reviews, the search identified a total of 10 862 articles. A total of 151 studies reporting on 78 792 patients were eligible for inclusion; where applicable, data from RCTs were included and meta-analyses were performed. For RCTs, there was low RoB across studies; however, clinical and methodological heterogeneity prevented data pooling for most studies. The majority of studies included were retrospective with matched or unmatched cohorts based on single or multi-institutional data or national registries. The exception was for systemic treatment of metastatic RCC, in which several RCTs have been performed, resulting in recommendations based on higher levels of evidence.

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Section: Prognostic Factorsmentioning

confidence: 99%

EAU Guidelines on Renal Cell Carcinoma: 2014 Update

Ljungberg¹,

Bensalah²,

Canfield³

et al. 2015

European Urology

2,675

1,914

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“…Several methods of quantifying these tumours have been proposed as an objective means of pre-operative assessment and will play an increasing role in the future as urologists carefully weigh the risks and benefits of treatment decisions for SRMs. [73][74][75][76] …”

Section: Equivalent Complication Ratesmentioning

confidence: 99%

886 Partial nephrectomy for the treatment of renal cell carcinoma and the risk of end stage renal disease

Yap¹,

Alibhai²,

Tomlinson³

et al. 2013

European Urology Supplements

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The surgical management of renal masses involves either radical nephrectomy (RN) or partial nephrectomy (PN). PN has been associated with better long-term renal function, and has also been linked to improved cardiac morbidity and overall survival. However, the relationship between treatment choice and definitive outcomes of chronic kidney disease (CKD) are lacking. Our aim was to examine whether PN is associated with a lower risk of end-stage renal disease (ESRD) requiring renal replacement therapy.We performed a population-based, retrospective cohort study with data from linked administrative databases in the province of Ontario, Canada. We included individuals with pathologically confirmed renal cell carcinoma (RCC) diagnosed between 1995 and 2010. Cox proportional hazards (PH) models, propensity score models, and competing risks models were used to assess the impact of treatment choice. PN compared to RN reduces the risk of ESRD requiring renal replacement therapy in a modern cohort of patients (2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010). PN is associated with a lower risk of new-onset CKD, lower risk of cardiac morbidity, and improved overall survival. We provide further evidence for the benefit of PN compared to RN, particularly related to definitive outcomes of renal failure.iii ACKNOWLEDGEMENTS

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“…To perform this step accurately, the cursor was stabilized on the HP during scrolling in the same way as the C index was measured previously. 7 The Pythagorean theorem was used to calculate the distance c based on the equation, √( x 2 +y 2 )=c. The m-CI was obtained by dividing c by r (Fig.…”

Section: Surgical Techniquesmentioning

confidence: 99%

“…5,6 Renal functional loss (RFL) following LPN has been well-evaluated and several reports have attempted to predict RFL following LPN on the basis of preoperative information. Some anatomical classification systems, such as the Centrality index (C index), 7 Preoperative Aspects and Dimensions Used for an Anatomical (PADUA) classification system, 8 and R.E.N.A.L. nephrometry score, 9 have been developed.…”

Section: Introductionmentioning

confidence: 99%

“…7 However, based on the principles of renal anatomy, the distance between the renal hilus and renal tumour would have a greater influence on the RFL following LPN. Therefore, to predict RFL following LPN, the present study aimed to modify the C index to quantify the distance between the renal hilum and the renal tumour, termed the modified C index (m-CI), and to validate the accuracy and superiority of the m-CI.…”

Section: Introductionmentioning

confidence: 99%

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Modified C index: Novel predictor of postoperative renal functional loss of laparoscopic partial nephrectomy

Ito

Makiyama

Kawahara

et al. 2017

CUAJ

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Introduction: We aimed to develop a scoring system to quantify the distance between the renal hilum and renal tumour, termed the modified C index (m-CI), and to predict renal functional loss (RFL) following laparoscopic partial nephrectomy (LPN). Methods: The m-CI was measured by using computed tomography in 113 patients who underwent LPN between May 2003 and June 2014. The RFL following LPN was calculated by examining the estimated glomerular filtration rate (eGFR) and radioisotope renography one year postoperatively. The Pythagorean theorem was used to calculate the distance from the tumour centre to the renal hilum. The distance was divided by the tumour radius to obtain the m-CI. The correlation between the m-CI and the postoperative RFL were evaluated using Pearson's coefficient values. Multivariate logistic regression models were used to assess the potential predictive factors of RFL following LPN. The correlation between the m-CI and the operative time, ischemia time, and blood loss during LPN were also evaluated by the unpaired t-test. Results: Pearson's coefficient values between the postoperative RFL and the m-CI and C index were 0.294 and 0.173, respectively. In the multivariate analysis, the resected volume (p=0.031) and m-CI (p=0.036) significantly correlated with the postoperative RFL following LPN. The operative time (p<0.001), ischemia time (p=0.028), and blood loss (p=0.047) during LPN was significantly longer and larger, respectively, in the group with shorter m-CI (≤4.5) than in the group with the longer m-CI (>4.5). Conclusions:The present study demonstrates that the m-CI can predict RFL following LPN, as well as the surgical difficulty.

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Kidney Tumor Location Measurement Using the C Index Method

Abstract: Centrality index scoring provides a clinically useful measure of tumor centrality. This system may allow improved clinical and radiological assessment of kidney tumors, and improved reporting of quantitative tumor site.

Cited by 340 publications

References 4 publications

EAU Guidelines on Renal Cell Carcinoma: 2014 Update

EAU Guidelines on Renal Cell Carcinoma: 2014 Update

886 Partial nephrectomy for the treatment of renal cell carcinoma and the risk of end stage renal disease

Modified C index: Novel predictor of postoperative renal functional loss of laparoscopic partial nephrectomy

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