Kidney transplantation in small children with live related donors: 20 years of experience

Ruiz, Eduardo; Cateriano, Javier Escalante; Lobos, Pablo; Badiola, Francisco I.P. de; Boer, Marcelo; Moldes, Juan; Puigdevall, J.; Ferraris, Jorge R.

doi:10.1016/j.jpurol.2006.05.005

Cited by 15 publications

(14 citation statements)

References 20 publications

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“…In case of vascular risk (according to surgeon's experience) after initial prophylaxis with enoxaparin during initial hospitalization, at‐risk patients receive aspirin. This policy of LD selection differs obviously between centers: In some series, the rate of LD is 100%, whereas some groups report no living donation; most RTx teams report a 30‐50% proportion of living donation in children below 15 kg …”

Section: Discussionmentioning

confidence: 99%

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Renal transplantation in children under 3 years of age: Experience from a single‐center study

Loiseau

Bacchetta

Klich

et al. 2018

Pediatric Transplantation

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RTx remains challenging in children under 3 years of age. This single-center study reviewed the medical records of children <3 years transplanted since 1987 (N = 32, Group 1). They were matched for donor type and RTx period with children aged 3-13 years (N = 32, Group 2) and 13-18 years (N = 32, Group 3). There were no between-group significant differences regarding distributions of gender, primary renal disease, proportion of dialysis before RTx, and growth (SDS). Compared to Groups 2 and 3, Group 1 had more peritoneal dialyses (P < .001), more EBV mismatches (P = .04), and longer warm ischemia times (P < .001). The risk of graft loss was not significantly different among age groups (hazard ratio, 2.4 in Group 2 and 2.0 in Group 3 vs Group 1; P = .2). Death occurred in four patients (3 in Group 1 and 1 in Group 2) and graft loss occurred in 28 patients, mainly due to chronic allograft nephropathy. In recipients <3 years of age, the outcomes of RTx are close to those obtained in older pediatric age groups. Thus, young patients may be transplanted in experienced multidisciplinary teams without additional risks provided that particular attention is paid to donor selection and prevention/early diagnosis of comorbidities and complications.

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Section: Discussionmentioning

confidence: 99%

“…These results are similar to previously reported ones. Some series reported a 100% young patient survival at 10 years in case of living donation …”

Section: Discussionmentioning

confidence: 99%

Renal transplantation in children under 3 years of age: Experience from a single‐center study

Loiseau

Bacchetta

Klich

et al. 2018

Pediatric Transplantation

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“…[183334] Since 1985, 23 patients between one and 10 years of age (male 16 / females seven) with ESRD and a weight lower than 17kg(8,9–16,9) were operated and received their first transplantation with a live related renal donor. The etiology of the ESRD that led to kidney transplantation showed more than 50% of patients with different types of urologic problems.…”

Section: Surgical Technical Considerationsmentioning

confidence: 99%

25 years of live related renal transplantation in children: The Buenos Aires experience

Ruiz¹,

Ferraris²

2007

Indian J Urol

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The number of pediatric patients with end stage renal disease (ESRD) has been steadily growing during the last 10 years all over the world, because of the improvement of medical and surgical treatment of severe urologic malformations and congenital and acquired nephrological disorders. Kidney transplantation (Tx) with a live related donor continues to be the gold standard therapy to treat ESRD in children because of the best final results, the chronic lack of cadaveric donors and the frequent possibility of young patients to have parents or relatives as a source of a potential graft donor.Nowadays almost every pediatric patient can be dialyzed and transplanted, even early in life, if he or she has the possibility of a live related donor. Improvements in pediatric anesthesiology and intensive care have also been very important, in reducing the morbidity and mortality related to Tx procedures.Here we report our experience with Tx for the last 25 years, specially our long experience of live related donor transplantation in children and adolescents with emphasis on technical issues in small children and pediatric patients with severe urologic malformations and bladder dysfunction. We'll make special considerations on the improvement in short and long follow-up with the actual prevention and treatment of graft rejection, due to the new immunosuppressive agents and protocols.

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“…The pertinent reference quoted in the study by Ruiz et al. does not report this as a usual problem and depicts a figure showing the classical routing of the vessels (artery anterior to the cava) . Indeed, this appears to be more of a theoretical concern.…”

mentioning

confidence: 99%

Vascular anastomosis for pediatric renal transplantation – A potential new strategy in low‐weight children?

Salle

Lorenzo

2014

Pediatric Transplantation

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Kidney transplantation in small children with live related donors: 20 years of experience

Cited by 15 publications

References 20 publications

Renal transplantation in children under 3 years of age: Experience from a single‐center study

Renal transplantation in children under 3 years of age: Experience from a single‐center study

25 years of live related renal transplantation in children: The Buenos Aires experience

Vascular anastomosis for pediatric renal transplantation – A potential new strategy in low‐weight children?

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