Kidney transplantation in primary oxalosis: data from the EDTA Registry

Abstract

Abstract. This paper reports the results of 98 first kidney transplantations in patients with oxalosis as the primary renal disease as recorded by the EDTA Registry. There were 79 patients who received a cadaveric (CAD) graft and 15 patients with a living related donor (LRD) graft; the type of donor was not recorded for four patients. Initial graft survival appeared to be better after LRD as compared to CAD grafts but at 3 years the poor survival was similar with 23% for LRD and 17% for CAD grafts. CAD graft survival did not differ between children and adults and was not affected by the waiting time on dialysis. A slight improvement was observed in grafts performed in the years 1983-1986 as compared to grafts performed in earlier years. The causes of failure reported were mainly rejection (33%) and recurrence of primary renal disease (31 %). In view of the poor results related to recurrence of Correspondence and offprint requests to: Professor F. P. Brunner, EDTA Registry, St Thomas' Hospital, London SE1 7EH, UK. Tel: 01-633 0636. oxalosis in the graft, the potential of combined kidney and liver transplantation is discussed.

Twenty-five years of renal transplantation from: a single center a risk factor analysis for short- and long-term outcomes

“…The number of children in our series is relatively small; however, our results are in accord with those reported by others [1,5,21]. The incidence of technical factors as reasons for graft failure was greater in children than in adults according to the EDTA registry [1].…”

Primary hyperoxaluria 1: catch up growth and normalization of oxaluria 6 years after hepatorenal transplantation in a prepubertal boy

“…The present case demonstrates that in contrast to isolated kidney TPL [4], combined hepatorenal TPL oers the chance of complete rehabilitation after endstage renal insuciency due to PH1 even in very young children. However, a favourable outcome is not always guaranteed [9].…”

Transplantation Outcomes in Primary Hyperoxaluria

“…Prior to 1990 outcomes of transplantation in primary hyperoxaluria were poor, to the extent that the appropriateness of transplantation for patients with PH was questioned (14,26). Loss of function due to oxalate deposition in the transplanted kidney and death related to systemic oxalosis were particular problems.…”