Kidney Transplantation in Children

Dharnidharka, Vikas R.; Fiorina, Paolo; Harmon, William

doi:10.1056/nejmra1314376

Cited by 222 publications

(181 citation statements)

References 74 publications

Supporting

Mentioning

173

Contrasting

Unclassified

Order By: Relevance

“…The overall outcome of infant RTx has dramatically improved such that several registry data and single-center reports show 10-year patient and graft survivals of over 90 and 80 %, respectively [95]. Short-term problems after transplantation are more common in infants than in older children [5], but the long-term outcome figures in infants are better, with a relative hazard for graft failure being about 0.2-0.6 in infants as compared to adolescents [96].…”

Section: Discussionmentioning

confidence: 99%

Renal transplantation in infants

2015

View full text Add to dashboard Cite

Renal transplantation (RTx) has become an accepted mode of therapy in infants with severe renal failure. The major indications are structural abnormalities of the urinary tract, congenital nephrotic syndrome, polycystic diseases, and neonatal kidney injury. Assessment of these infants needs expertise and time as well as active treatment before RTx to ensure optimal growth and development, and to avoid complications that could lead to permanent neurological defects. RTx can be performed already in infants weighing around 5 kg, but most operations occur in infants with a weight of 10 kg or more. Perioperative management focuses on adequate perfusion of the allograft and avoidance of thrombotic and other surgical complications. Important long-term issues include rejections, infections, graft function, growth, bone health, metabolic problems, neurocognitive development, adherence to medication, pubertal maturation, and quality of life. The overall outcome of infant RTx has dramatically improved, with long-term patient and graft survivals of over 90 and 80 %, respectively.

show abstract

Section: Discussionmentioning

confidence: 99%

Renal transplantation in infants

2015

View full text Add to dashboard Cite

show abstract

“…In the original reports on infant RTx, frequencies up to 30% were reported, but recently the incidence of thrombosis has been 2-10% in infants 7 . It is desirable to maintain a central venous pressure above 10 cm water prior to unclamping and the mean arterial pressure at more than 60 mm Hg 7,8 . After the operation, attention to the intravascular volume and electrolyte and acid-base stability is essential to ensure good renal function.…”

Section: Discussionmentioning

confidence: 99%

A child weighing 8.5 kg with bilateral congenital dysplastic kidneys and end stage renal failure who has undergone a successful renal transplant

Ranawaka

Pinto

Lamawansa

et al. 2017

Sri Lanka J Child Health

View full text Add to dashboard Cite

“…Graft survival among pediatric kidney transplant recipients has improved significantly over the past decade [1] (Fig. 5) [7].…”

Section: Graft Survivalmentioning

confidence: 99%

“…The leading cause of death among pediatric kidney transplant recipients is infection (28.5%), followed by cardiopulmonary (14.7%), malignancy (11.3%), and dialysis related complications (3.1%) [1]. Almost half of these patients died with a functioning graft.…”

Section: Patient Survivalmentioning

confidence: 99%

“…There has been significant progress made in the field of kidney transplant including immunosuppressive drug therapy, graft, and patient survival. This progress can be attributed to advances in numerous factors including pre-transplant care, surgical advances, changes in deceased donor allocation policy, and more potent immunosuppressive medications [1]. We present data from North America on these successes and the ongoing challenges that face the pediatric transplant community.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Progress in Pediatric Kidney Transplantation

Smith¹,

Dharnidharka²

2014

TOUNJ

View full text Add to dashboard Cite

Significant progress has been made in pediatric kidney transplantation. Advances in immunosuppression have dramatically decreased rates of acute rejection leading to improved short term graft survival but similar improvements in long term graft survival remain elusive. Changes in allocation policy provide the pediatric population with timely access to transplant but there remains concern about the impact of less HLA matching and a decrease in living donors. This report presents data from North America on these successes and the ongoing challenges that face the pediatric transplant community.

show abstract

Kidney Transplantation in Children

Cited by 222 publications

References 74 publications

Renal transplantation in infants

Renal transplantation in infants

A child weighing 8.5 kg with bilateral congenital dysplastic kidneys and end stage renal failure who has undergone a successful renal transplant

Progress in Pediatric Kidney Transplantation

Contact Info

Product

Resources

About