Kidney transplantation from non-heart-beating donors

Daemen, Jan-Willem; Wit, alph J. de; Heineman, Erik; Kootstra, G.

doi:10.1016/0955-470x(95)80001-o

Cited by 17 publications

(6 citation statements)

References 31 publications

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“…Thanks to the new immunosuppressive agents, human leukocyte antigen (HLA) matching protocols, and optimized follow-up in transplanted patients, graft survival rate has improved and the incidence of the graft complications has been reduced. 1 However, studies still report about 7% to 10% acute graft loss within the first postoperative week because of the surgical and nonsurgical complications. 2,3 Identifying postoperative complications at an earlier stage would have a major impact on reducing the rate of graft loss.…”

Section: Introductionmentioning

confidence: 99%

Early Detection of Metabolic Changes Using Microdialysis During and After Experimental Kidney Transplantation in a Porcine Model

et al. 2011

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Section: Introductionmentioning

confidence: 99%

Early Detection of Metabolic Changes Using Microdialysis During and After Experimental Kidney Transplantation in a Porcine Model

et al. 2011

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“…R75231 can be used clinically for the procurement of organs from non-heartbeating donors. Non-heartbeating donors have been classified into four categories (44): dead on arrival (category 1); unsuccessful resuscitation (category 2); awaiting cardiac arrest (category 3); and cardiac arrest while brain dead (category 4). At the very least R75231 treatment would be indicated for category 3 donors.…”

Section: Discussionmentioning

confidence: 99%

Attenuation of Ischemic Liver Injury by Augmentation of Endogenous Adenosine1,2

Todo

Zhu²,

Zhang³

et al. 1997

Transplantation

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Hepatic grafts from non-heartbeating donors may alleviate the organ shortage, but they inherently suffer from warm ischemia. In the present study, we tested our hypothesis that augmentation of endogenous adenosine by inhibition of nucleoside transport with R75231 attenuates ischemic liver injury. Adult female beagle dogs underwent 2-hr hepatic vascular exclusion with venovenous bypass. R75231 was given to the animals by continuous intravenous infusion for 30 min before ischemia at a dose of 0.1 mg/kg (Group 2, n=6), 0.05 mg/kg (Group 3, n=6), or 0.025 mg/kg (Group 4, n=6). Nontreated animals were used as the control (Group 1, n= 10). Animal survival, hepatic tissue blood flow, liver function, and histopathology were analyzed. Two-week animal survival was 30% in Group 1, 83% in Group 2, 100% in Group 3, and 100% in Group 4. Postreperfusion hepatic tissue blood flow was markedly improved by the treatment. Treatment significantly attenuated liver enzyme release, lipid peroxidation, and changes in adenine nucleotides and purine catabolites. Structural abnormality of the liver after reperfusion was markedly improved by R75231 treatment, showing better architecture and less neutrophil infiltration. Preischemic administration of a nucleoside transport inhibitor ameliorated ischemic liver injury due to the positive effects of augmented endogenous adenosine, and is applicable clinically when the liver is procured from a controlled non-heartbeating donor.

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“…The most intriguing application of HPA machine perfusion is its potential use in rescuing grafts from nonheart-beating donors [6,221. The ability of the HPA to provide adequate perfusion at lower flow rates than conventional machine perfusion may reduce additional damage by preservation.…”

Section: Discussionmentioning

confidence: 99%

An automated and portable low-flow pulsatile petfusion system for organ preservation

Yland¹,

Todo²,

Zhu³

et al. 1996

Transplant Int

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While machine preservation reduces the incidence of delayed graft function in renal transplant recipients, it is only used in 10% of kidney transplantations. The performance of our portable, low-flow-pulsatile organ perfusion system was examined in a canine kidney autotransplantation model. Grafts were stored for 72 h by simple cold preservation in University of Wisconsin (UW) solution, or by high or low-flow machine preservation After preservation, the grafts were autotransplanted and the animals were followed for 15 days. Graft function was better in machine-preserved kidneys. Tissue biochemistry indicated that machine preservation resulted in higher levels of adenine nucleotides and better histological integrity than the cold storage. While histology and biochemistry of machine-preserved groups were similar, electromicroscopy of high-flow grafts showed mild accumulation of intravenous debris and endothelial swelling. This study shows that a simplified machine perfusion technique is effective for organ preservation.

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Kidney transplantation from non-heart-beating donors

Cited by 17 publications

References 31 publications

Early Detection of Metabolic Changes Using Microdialysis During and After Experimental Kidney Transplantation in a Porcine Model

Early Detection of Metabolic Changes Using Microdialysis During and After Experimental Kidney Transplantation in a Porcine Model

Attenuation of Ischemic Liver Injury by Augmentation of Endogenous Adenosine1,2

An automated and portable low-flow pulsatile petfusion system for organ preservation

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