Kidney Transplantation From Brain-Dead Donors: Initial Experience in China

Li, Y.; Li, J.; Fu, Qian; Chen, L.; Fei, J.; Deng, Shijie; Qiu, Jian; Chen, G.; Huang, Gang; Wang, C.

doi:10.1016/j.transproceed.2016.07.027

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…Looking at the final results of our series, there was no loss of graft as well as no loss of a patient in 1, 3, and 4 years of follow-up postoperatively. Patient's graft function along with graft and patient survival outcomes in this series were compared with existing literature [ 7 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Kidney transplantation from brain-dead donors in Nepal: Report of first six cases

Shrestha¹,

Bhandari²,

Devbhandari³

et al. 2022

Annals of Medicine &Amp; Surgery

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Section: Discussionmentioning

confidence: 99%

Kidney transplantation from brain-dead donors in Nepal: Report of first six cases

Shrestha¹,

Bhandari²,

Devbhandari³

et al. 2022

Annals of Medicine &Amp; Surgery

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“…One of the authors' previous studies using rabbits focused on examining the alterations to liver protein expression (16). A relatively small number of studies have been published on rabbits' kidney injury induced by brain death, including hemodynamic changes, release of inflammatory cytokines, apoptosis, consumption of coagulation factors, endocrine and hormonal changes (1–3). To the best of our knowledge, no prior studies have used proteomics to investigate differentially expressed proteins in rabbit kidney induced by brain death.…”

Section: Discussionmentioning

confidence: 99%

“…Brain dead donors are becoming a major source of organ transplantation in China (1–3). Although the number of kidney transplantations from brain dead donors has markedly increased, the supply of donor kidneys still do not meet requirements (4,5).…”

Section: Introductionmentioning

confidence: 99%

Proteomic analysis of differentially expressed proteins in kidneys of brain dead rabbits

et al. 2017

Molecular Medicine Reports

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A large number of previous clinical studies have reported a delayed graft function for brain dead donors, when compared with living relatives or cadaveric organ transplantations. However, there is no accurate method for the quality evaluation of kidneys from brain-dead donors. In the present study, two-dimensional gel electrophoresis and MALDI-TOF MS-based comparative proteomic analysis were conducted to profile the differentially-expressed proteins between brain death and the control group renal tissues. A total of 40 age- and sex-matched rabbits were randomly divided into donation following brain death (DBD) and control groups. Following the induction of brain death via intracranial progressive pressure, the renal function and the morphological alterations were measured 2, 6 and 8 h afterwards. The differentially expressed proteins were detected from renal histological evidence at 6 h following brain death. Although 904±19 protein spots in control groups and 916±25 in DBD groups were identified in the two-dimensional gel electrophoresis, >2-fold alterations were identified by MALDI-TOF MS and searched by NCBI database. The authors successfully acquired five downregulated proteins, these were: Prohibitin (isoform CRA_b), beta-1,3-N-acetylgalactosaminyltransferase 1, Annexin A5, superoxide dismutase (mitochondrial) and cytochrome b-c1 complex subunit 1 (mitochondrial precursor). Conversely, the other five upregulated proteins were: PRP38 pre-mRNA processing factor 38 (yeast) domain containing A, calcineurin subunit B type 1, V-type proton ATPase subunit G 1, NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 and peroxiredoxin-3 (mitochondrial). Immunohistochemical results revealed that the expressions of prohibitin (PHB) were gradually increased in a time-dependent manner. The results indicated that there were alterations in levels of several proteins in the kidneys of those with brain death, even if the primary function and the morphological changes were not obvious. PHB may therefore be a novel biomarker for primary quality evaluation of kidneys from brain-dead donors.

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“…El protocolo de estudio en el donador renal incluye una diversidad de estudios bioquímicos, bacteriológicos, virales, inmunológicos y de imagen, que de manera relativa ofrecen cierto grado de complejidad al equipo de salud; sin embargo, una vez que este grupo multidisciplinario adopta esta práctica y los estudios se realizan con mayor frecuencia, se convierten en procedimientos cotidianos, en donde los profesionales de la salud se adaptan, los integran y dominan; de manera que prácticamente no existen obstáculos para realizarlos. 5 Los laboratorios de histocompatibilidad aún no tienen los recursos necesarios para realizar pruebas cruzadas y human leucocyte antigen (HLA), que deberían dar la pauta inicial para el estudio tanto de donadores como receptores, lo cual sería de gran utilidad para mejorar la donación de manera local, regional y hasta internacional, 6,7 práctica no aprobada por la Ley General de Salud de México; por lo tanto, no promovida por el IMSS. La supervivencia del injerto renal en los últimos años supera el 95% al primer año de trasplante y alcanza el 90% a los cinco años, lo cual es producto de la mejor selección de los donadores y la efectividad de los medicamentos inmunosupresores.…”

Section: Materials Y Métodosunclassified

Comportamiento de la referencia a trasplante renal en el Instituto Mexicano del Seguro Social

Méndez-Durán¹

2020

Revista Mexicana De Trasplantes

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Introduction: The substitute therapies of the renal function constitute a support of life, nevertheless they are temporary treatments until realizing renal transplantation (TR), meanwhile the complications are present the deterioration of the quality and reduction of the life expectancy. The TR rehabilitates, gives the possibility of a normal life, family, social and labor reintegration. The reference to TR day by day becomes more frequent and knowing the behavior will allow to implement improvement strategies. Material and methods: Retrospective and cross-sectional study conducted from 2014 to 2019, includes data on references to TR generated by the general and regional hospitals of the IMSS of subjects up to 65 years of age. Reference location is identified, gender, age, cause of chronic renal failure (CRF), modality of replacement therapy. Results: 19,979 patients were referred, 12,386 were male (62%) and 7,593 female (38%), aged 1 to 65 years, the group of 20 to 29 years was the most prevalent (30%). The highest number of references received peritoneal dialysis 9,166 (46%), hemodialysis 8,981 (45%), and 1,832 (9%) pre-dialysis. The reference increased 8.7% annual average in all the dialysis modalities. Conclusions: The reference presents a continuous increase and pre-dialysis patients each year are referred in greater numbers. The demand for renal transplantation exceeds the needs of the institution and offers a large area of opportunity to favor a greater number of patients.

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Kidney Transplantation From Brain-Dead Donors: Initial Experience in China

Cited by 5 publications

References 17 publications

Kidney transplantation from brain-dead donors in Nepal: Report of first six cases

Kidney transplantation from brain-dead donors in Nepal: Report of first six cases

Proteomic analysis of differentially expressed proteins in kidneys of brain dead rabbits

Comportamiento de la referencia a trasplante renal en el Instituto Mexicano del Seguro Social

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