Kidney stone disease

Younis, Ayman; Radharikrishnan, Suresh

doi:10.1002/tre.177

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Men are more likely to have urolithiasis than women 8 . Moreover, there are socioeconomic differences for most diseases worldwide as Caucasians and Asians are more likely to develop upper urinary stones compared to Hispanics, and African Americans 9 . Due to these discrepancies in renal stone distribution, to increase the external validity of clinical trials, researchers recommend studying populations which are a true representative of real patients.…”

Section: Introductionmentioning

confidence: 99%

Assessment of health equity consideration in Cochrane systematic reviews and primary studies on urolithiasis

Basirat

Soleimani

Shakiba

et al. 2023

Health Science Reports

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Background and Aims: Health injustice is defined as "unnecessary, preventable, unjustified and unfair health differences." One of the most important scientific sources on the prevention and management of urolithiasis are Cochrane reviews in this field. Given that the first step in eliminating health injustice is to identify the causes, the aim of the present study was to evaluate equity considerations in Cochrane reviews and the included primary studies on urinary stones.Methods: Cochrane reviews on kidney stones and ureteral stones were searched through the Cochrane Library. The included clinical trials in each of the reviews published after 2000 were also collected. Two different researchers reviewed all the included Cochrane reviews and primary studies. The researchers reviewed each PROGRESS criteria independently

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Section: Introductionmentioning

confidence: 99%

Assessment of health equity consideration in Cochrane systematic reviews and primary studies on urolithiasis

Basirat

Soleimani

Shakiba

et al. 2023

Health Science Reports

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“…Our findings can help provide the medical and surgical support needed for nephrolithiasis patients and offer key opportunities to learn more about nephrolithiasis, thereby fueling the much-needed research in this field. However, various factors were associated with the formation and recurrence of CaOx crystal in the kidney, and more in-depth studies are required in order to elucidate the specific mechanisms by which MUC4 eases nephrolithiasis [49,50].…”

Section: Discussionmentioning

confidence: 99%

Mucin 4 Gene Silencing Reduces Oxidative Stress and Calcium Oxalate Crystal Formation in Renal Tubular Epithelial Cells Through the Extracellular Signal-Regulated Kinase Signaling Pathway in Nephrolithiasis Rat Model

Sun¹,

Zou²,

Wang³

et al. 2018

Kidney Blood Press Res

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Background/Aims: Nephrolithiasis plagues a great number of patients all over the world. Increasing evidence shows that the extracellular signal-regulated kinase (ERK) signaling pathway and renal tubular epithelial cell (RTEC) dysfunction and attrition are central to the pathogenesis of kidney diseases. Mucin 4 (MUC4) is reported as an activator of ERK signaling pathway in epithelial cells. In this study, using rat models of calcium oxalate (CaOx) nephrolithiasis, the present study aims to define the roles of MUC4 and ERK signaling pathway as contributors to oxidative stress and CaOx crystal formation in RTEC. Methods: Data sets of nephrolithiasis were searched using GEO database and a heat flow map was drawn. Then MUC4 function was predicted. Wistar rats were prepared for the purpose of model establishment of ethylene glycol and ammonium chloride induced CaOx nephrolithiasis. In order to assess the detailed regulatory mechanism of MUC4 silencing on the ERK signaling pathway and RTEC, we used recombinant plasmid to downregulate MUC4 expression in Wistar rat-based models. Samples from rat urine, serum and kidney tissues were reviewed to identify oxalic acid and calcium contents, BUN, Cr, Ca²⁺ and P³⁺ levels, calcium crystal formation in renal tubules and MUC4 positive expression rate. Finally, RT-qPCR, Western blot analysis, and ELISA were employed to access oxidative stress state and CaOx crystal formation in RTEC. Results: Initially, MUC4 was found to have an influence on the process of nephrolithiasis. MUC4 was upregulated in the CaOx nephrolithiasis model rats. We proved that the silencing of MUC4 triggered the inactivation of ERK signaling pathway. Following the silencing of MUC4 or the inhibition of ERK signaling pathway, the oxalic acid and calcium contents in rat urine, BUN, Cr, Ca²⁺ and P³⁺ levels in rat serum, p-ERK1/2, MCP-1 and OPN expressions in RTEC and H₂O₂ and MDA levels in the cultured supernatant were downregulated, but the GSH-Px, CAT and SOD levels in the cultured supernatant were increased. Moreover, MUC4 silencing or ERK signaling pathway inactivation may decrease the formation of CaOx crystals. Conclusion: Taken together, silencing of MUC4 can inactivate the ERK signaling pathway and further restrain oxidative stress and CaOx crystal formation in RTEC. Thus, MUC4 represents a potential investigative focus target in nephrolithiasis.

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Therapeutic potential of medicinal plants for the management of renal stones: A review

Rasool

Mousa

Alhamadani³

et al. 2022

Baghdad J. Biochem. Appl. Biol. Sci.

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Kidney stones are among the oldest and most widespread urinary tract ailments, impacting people all over the globe with a high recurrence rate. The mechanism of kidney stone formation includes events such as urine supersaturation, aggregation, retention, nucleation, and growth of crystals in the cells of the renal tubular epithelium. Kidney stones may cause extreme pain and blockage of urine flow. They are usually treated with synthetic drugs and extracorporeal shock wave lithotripsy (ESWL) as well as a variety of medications that may cause several adverse effects. The remaining stone fragments and the risk of infection following ESWL are severe problems in the treatment of kidney stones. Recently, despite the emergence of synthetic drugs, medicinal plants have been recognized and utilized in many nations due to their safety profile, efficiency, cultural acceptance, and fewer side effects than synthetic drugs. Medicinal plants are used in different cultures as a reliable source of natural remedies. The aim of this review is to provide comprehensive information about traditionally used antiurolithiatic plants as well as their scientifically proven pharmacological activities, their primary chemical ingredients, and potential mechanisms of action, such as analgesic, astringent, demulcent, diuretic activity, antioxidant activity, inhibition of the inflammatory process, nucleation inhibition, crystallization inhibition, inhibition of crystal aggregation, reducing hyperoxaluria, reducing stone size, and reducing urine supersaturation.

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Kidney stone disease

Cited by 3 publications

References 6 publications

Assessment of health equity consideration in Cochrane systematic reviews and primary studies on urolithiasis

Assessment of health equity consideration in Cochrane systematic reviews and primary studies on urolithiasis

Mucin 4 Gene Silencing Reduces Oxidative Stress and Calcium Oxalate Crystal Formation in Renal Tubular Epithelial Cells Through the Extracellular Signal-Regulated Kinase Signaling Pathway in Nephrolithiasis Rat Model

Therapeutic potential of medicinal plants for the management of renal stones: A review

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