Kidney sparing giant retroperitoneal liposarcoma: Case report and literature review

Argadjendra, Masjensen; Napitupulu, Rudi; Yudadi, Redemptus; Hoetama, Sakti; Wibowo, Heru Seno

doi:10.1016/j.ijscr.2019.02.008

Cited by 10 publications

(11 citation statements)

References 9 publications

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“…In a case series of 228 patients undergoing surgery for RLPS, the group of those not requiring multi-organ resection had a higher 10-year survival rate as opposed to those requiring multi-organ resection (35% vs 26%) (49). This suggests that, although invasion to renal parenchyma and the possibility of future recurrence from that site, the choice of performing a nephron-sparing resection must be balanced on the tumor's histologic type, patient's age, and increased morbidity from resection (50).…”

Section: Discussionmentioning

confidence: 99%

R0 Surgical Resection of Giant Dedifferentiated Retroperitoneal Liposarcomas in the COVID era: Nephrectomy or Not Nephrectomy?

Pegoraro

Santangelo

Alfonso

et al. 2022

Preprint

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Background: Retroperitoneal sarcomas (RPS) are rare findings that can grow into large masses without eliciting severe symptoms. Nowadays surgical resection is the only radical therapy, whenever possible. We present two consecutive cases of RPSs that resulted in dedifferentiated liposarcomas (DDLPS) and underwent R0 surgical resection with and without a nephron-sparing procedure. The diagnostic workup, the surgical approach, the impact of late surgical management due to the COVID pandemic, and the latest literature on the topic will be discussed and analyzed. Case Presentation: The patients, who refused to undergo any medical examination during the prior two years due to the COVID pandemic, were admitted to our Institution complaining about weight loss and general abdominal discomfort. In the first case, we observed a primitive giant abdominal right neoplasm of retroperitoneal origin enveloping and medializing the right kidney. The second patient had a similar primitive retroperitoneal giant left neoplasm which didn’t affect the kidney. Given the masses’ characteristics and the absence of distant metastases, after a multidisciplinary discussion, radical surgical removal was carried out for both patients. The lesions appeared well-defined from the surrounding tissues, and significantly compressed all the adjacent organs, without signs of infiltration. In the first patient, the right kidney was surrounded and undetachable from the tumor and it was removed en bloc with the mass. The second patient benefited from a nephron-sparing resection, thanks to the existence of a clear cleavage plane. The postoperative courses were uneventful. Both the histological examinations were oriented towards a DDLPS. And both patients were addressed with adjuvant chemotherapy. Conclusions: The treatment of giant RPS is still challenging and requires multidisciplinary treatment as well as, when possible, radical surgical removal. The lack of tissue infiltration and the avoidance of major organs’ excision or reconstruction (including the kidney) could lead to an easier postoperative course and a better prognosis. When possible, surgical management of recurrences or incompletely resected masses must be pursued. As the COVID pandemic caused limited medicalization of many population groups and delayed diagnosis of other oncologic diseases, an increased number of DDLPSs could be expected in the near future.

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Section: Discussionmentioning

confidence: 99%

R0 Surgical Resection of Giant Dedifferentiated Retroperitoneal Liposarcomas in the COVID era: Nephrectomy or Not Nephrectomy?

Pegoraro

Santangelo

Alfonso

et al. 2022

Preprint

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“…1 The histological variants are well-differentiated, dedifferentiated, pleomorphic, myxoid and round cell liposarcomas. 2 The tumours tend to be asymptomatic initially followed by a late presentation when the tumour has outgrown the retroperitoneal space. The most common symptom is abdominal mass or fullness, which is unilateral and progressively increasing.…”

Section: Descriptionmentioning

confidence: 99%

“…3 At a later stage of the disease, patients can present with gastrointestinal or urinary or neurological complaints owing to the compression or invasion of adjacent structures. 2 CECT remains the investigation of choice and allows us to identify the location, extension and the proximity to the neurovascular structures. Image-guided core-needle biopsy via retroperitoneal approach is the gold standard for diagnosis.…”

Section: Descriptionmentioning

confidence: 99%

Pictorial essay on a case of giant retroperitoneal liposarcoma

2020

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“…Intra-abdominal soft tissue sarcoma is a rare kind of tumor, which accounts for less 1 % of all malignant tumors. Retropertioneum is the primary site in about 15 % of soft tissue sarcomas [1] , [2] . Of all the kinds, liposarcoma presents the most common type of arising soft tissue sarcomas, taking up about 45 % [3] and about 41 % at lower extremities, and about 11 % chiefly in thighs [4] .…”

Section: Introductionmentioning

confidence: 99%

Surgery of intraabdominal giant dedifferentiated liposarcoma of ascending colon mesentery: A rare case report

Park

Kuk²,

Lim³

2022

International Journal of Surgery Case Reports

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Kidney sparing giant retroperitoneal liposarcoma: Case report and literature review

Cited by 10 publications

References 9 publications

R0 Surgical Resection of Giant Dedifferentiated Retroperitoneal Liposarcomas in the COVID era: Nephrectomy or Not Nephrectomy?

R0 Surgical Resection of Giant Dedifferentiated Retroperitoneal Liposarcomas in the COVID era: Nephrectomy or Not Nephrectomy?

Pictorial essay on a case of giant retroperitoneal liposarcoma

Surgery of intraabdominal giant dedifferentiated liposarcoma of ascending colon mesentery: A rare case report

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