2021
DOI: 10.1038/s41581-021-00394-7
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Kidney physiology and susceptibility to acute kidney injury: implications for renoprotection

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Cited by 171 publications
(173 citation statements)
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“… 72 Further, the kidney’s unique vascularization leads to regional heterogeneity of oxygen supply and differential susceptibility to hypoxia. 61 Renal biopsies have demonstrated vascular changes, including cortical necrosis, tubular necrosis, and thrombotic microangiopathy in kidney tissue of patients with AKI, supporting a central role for vascular involvement in AKI. 66 An accumulation of uremic toxins is associated with endothelial damage and microvascular injury in AKI.…”
Section: What Is Known About the Etiology And Pathophysiology Of Severe Malaria-associated Aki?mentioning
confidence: 92%
See 2 more Smart Citations
“… 72 Further, the kidney’s unique vascularization leads to regional heterogeneity of oxygen supply and differential susceptibility to hypoxia. 61 Renal biopsies have demonstrated vascular changes, including cortical necrosis, tubular necrosis, and thrombotic microangiopathy in kidney tissue of patients with AKI, supporting a central role for vascular involvement in AKI. 66 An accumulation of uremic toxins is associated with endothelial damage and microvascular injury in AKI.…”
Section: What Is Known About the Etiology And Pathophysiology Of Severe Malaria-associated Aki?mentioning
confidence: 92%
“…Proximal tubular cells have a high metabolic rate and are susceptible to injury from ischemia or endogenous or exogenous toxins. 61 Endogenous nephrotoxins are a frequent etiological factor of AKI in children in sub-Saharan Africa. 62 Ultrastructural examination of kidney tissue of adults with fatal severe malaria reveals parasite sequestration in glomerular and tubulointerstitial vessels and monocyte accumulation in glomerular capillaries.…”
Section: What Is Known About the Etiology And Pathophysiology Of Severe Malaria-associated Aki?mentioning
confidence: 99%
See 1 more Smart Citation
“…The most common causes of AKI, characterized by a sudden decrease in renal function, include ischemic insults, sepsis and poisoning, wherein hypoxia, pathogen- or damage-associated molecular patterns, inflammatory cytokines and environmental toxins or drugs damage the kidney, and particularly the tubular epithelium [ 251 , 252 , 253 ]. Its incidence is high (estimated to be 2–20% in hospitalized patients) and its mortality remains around 20% [ 251 ]. Of recent interest, AKI develops in 10% of hospitalized Covid-19 patients [ 254 ].…”
Section: Mrtf In Kidney Diseasesmentioning
confidence: 99%
“…It has been established that tubular dilatation, tubular epithelial damage, cast formation, and debris accumulation were all found in the renal medulla of ARF [9,26,27]. To confirm the effect of JGE administration on tubular injury, PAS staining analysis was performed.…”
Section: Discussionmentioning
confidence: 99%