Kidney Outcomes and Hypertension in Survivors of Wilms Tumor: A Prospective Cohort Study

Chu, David I.; Ehlayel, Abdulla M.; Ginsberg, Jill P.; Meyers, Kevin; Benton, Maryjane; Thomas, Melissa; Carlson, Claire A.; Kolon, Thomas F.; Tasian, Gregory E.; Greenberg, Jason; Furth, Susan L.

doi:10.1016/j.jpeds.2020.12.005

Cited by 19 publications

(10 citation statements)

References 33 publications

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“…In our ABPM-pilot study, MH was observed in 7.8% and WCH in 2.6%. In other CCS studies, MH was seen in 0% [23] up to 34% of Wilms tumour survivors [26]. Comparison of our findings is difficult because these studies were mainly performed on children and cohorts are heterogeneous.…”

Section: Discussionmentioning

confidence: 48%

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Hypertension in long-term childhood cancer survivors after treatment with potentially nephrotoxic therapy; DCCSS-LATER 2: Renal study

Kooijmans

Pal

Pluijm

et al. 2022

European Journal of Cancer

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Section: Discussionmentioning

confidence: 48%

“…It better reflects actual BP, and nocturnal BP is the most significant predictor of CVD [19e21]. Studies in various cohorts of CCS using ABPM [15,22e26] reported insufficient nocturnal dipping [23,24,26] or deviant night-time diastolic BP (DBP) [15,22,25]. Unfortunately, these studies included small patient numbers.…”

Section: Introductionmentioning

confidence: 99%

Hypertension in long-term childhood cancer survivors after treatment with potentially nephrotoxic therapy; DCCSS-LATER 2: Renal study

Kooijmans

Pal

Pluijm

et al. 2022

European Journal of Cancer

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“…11,19 High risk for selective reporting was associated with three studies. 8,10,15 Furthermore, 30% of the studies were associated with low risk, 50% with high risk for other types of bias, 7,8,[11][12][13][14][15]17 and the remaining 20% with unclear risk for other bias 18,20 (►Fig. 2).…”

Section: Resultsmentioning

confidence: 99%

Meta-Analysis on Long-Term Outcomes of Pediatric Renal Cancer Survivors Following COG and SIOP Protocols

et al. 2022

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Background Pediatric renal cancer survivors have higher rate of chronic renal disease and hypertension. These patients have similar survival rates when treated according to either Children's Oncology Group (COG) or International Society of Pediatric Oncology (SIOP) protocols. We aimed to compare the late outcome of these two approaches. Methods We performed a meta-analysis of all studies from 2000 to 2021; database search using keywords: long-term outcomes OR late effects, nephrectomy, pediatric renal cancer. For each protocol, data were collected, and the “pooled” outcomes were compared. Continuous and dichotomous variables were obtained with a 95% odds ratio. Results Sixteen studies with a total of 715 pediatric renal cancer survivors were analyzed. The mean follow-up time was 17.4 (standard deviation 5.6) years. Reduced renal function and hypertension were the most encountered long-term complications. The mean estimated glomerular filtration rate was similar in both protocols (101.62 vs. 101.70 mL/min/1.73 m2), while the prevalence of hypertension was 23% in COG and 10% in SIOP. The prevalence of secondary malignancy was 1.1% in COG and 6.7% in SIOP (1.1% vs. 6.7%, p ≤ 0.001). Chronic kidney disease was similar in both groups. Conclusion A high prevalence of hypertension was observed among pediatric renal cancer survivors, as well as an increased risk of a secondary tumor. These results emphasize the importance of long-term follow-up into adulthood, to promptly diagnose any long-term side effects of the treatment. Thanks to the increased overall survival, future protocols will pay attention to the reduction of long-term sequelae.

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“…El Tumor de Wilms o nefroblastoma es el segundo cáncer intraabdominal más común de la infancia y la quinta neoplasia maligna más frecuente en la edad pediátrica. Representa aproximadamente el 6% de todos los cánceres pediátricos y es el tumor renal más frecuente (más del 95% del total de tumores renales pediátricos) 4 . Se produce entre los 2 a 5 años de edad, siendo el 95% de los niños diagnosticados antes de los 10 años 5 , la edad de nuestro paciente es de 3 años.…”

Section: Discussionunclassified

Artritis tuberculosa del tobillo. Reporte de caso

Bouchentouf¹

2021

Rev. Fac. Cienc. Méd. Univ. Cuenca.

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Introducción: la tuberculosis del astrágalo no es una patología frecuente, por esta razón se retarda su diagnóstico y tratamiento oportunos, necesarios para evitar la destrucción de las articulaciones y la deformidad esquelética. Caso clínico: paciente masculino de 45 años de edad presenta traumatismo del tobillo derecho de 5 años de evolución, antecedentes familiares de tuberculosis pulmonar; acude a emergencia por presentar en el tobillo derecho tumefacción dolorosa y fístula cutánea, además de fiebre, sudoración y malestar general. La radiografía y la Tomografía Axial Computarizada (TAC) del pie muestran una lesión osteolítica del astrágalo derecho. Es tratado con antibióticos para estafilococo sin mejorar la sintomatología. Se puncionó la herida, tomando muestras con resultado negativo en tinción Ziehl-Neelsen, cultivos de aerobios, anaerobios y citología. Se decide el abordaje quirúrgico de la lesión con drenaje. El estudio histopatólogico reveló la presencia de granulomas necrosantes. Se evidencia mejora clínica y de seguimiento radiológico 9 meses luego de tratamiento para tuberculosis. Conclusión: el presente caso nos muestra que en una lesión crónica inflamatoria de tobillo debe descartarse el diagnóstico de tuberculosis sobre todo en pacientes originarios de regiones endémicas de tuberculosis.

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Kidney Outcomes and Hypertension in Survivors of Wilms Tumor: A Prospective Cohort Study

Cited by 19 publications

References 33 publications

Hypertension in long-term childhood cancer survivors after treatment with potentially nephrotoxic therapy; DCCSS-LATER 2: Renal study

Hypertension in long-term childhood cancer survivors after treatment with potentially nephrotoxic therapy; DCCSS-LATER 2: Renal study

Meta-Analysis on Long-Term Outcomes of Pediatric Renal Cancer Survivors Following COG and SIOP Protocols

Artritis tuberculosa del tobillo. Reporte de caso

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