Kidney membrane proteins and epithelial transport

Recent advances in kidney research

“…In addition, it is also highly dependent on an accurate estimation of kidney function, which is the focus of a recent work by Claudel et al 7 Tightly controlled epithelial transport mechanisms in the kidney are fundamental for regulating the balance of electrolytes, water, and waste products crucial for maintaining proper physiological function and systemic homeostasis. 8 One of the important molecules might be the Two-pore channels protein 1 (TPC1) which was the focus of the work of Just et al 9 The methofds here include immunohistological stainings as well as functional studies in TPC1-deficient mice and their controls. The authors find that TPC1 is involved in regulating phosphate excretion through parathyroid hormone (PTH) signaling.…”