Kidney Injury Molecule-1 (KIM-1) in Blood Plasma of Patients with Clear-Cell Carcinoma

Novel Liquid Biomarkers and Innovative Imaging for Kidney Cancer Diagnosis: What Can Be Implemented in Our Practice Today? A Systematic Review of the Literature

“…[18]. Clear-cell RCC (ccRCC) and renal oncocytoma (RO) were the most frequent malignant and benign masses, respectively, in all but two studies [18,19]. The majority of patients had nonmetastatic RCC of pT1 stage.…”

“…Of these, 11 935 were excluded by title and abstract screening, with a further 367 excluded after full-text assessment. Of the records screened, 15 studies (six on liquid biomarkers [15][16][17][18][19][20] and nine on innovative imaging [21][22][23][24][25][26][27][28][29]) and eight clinical trials (one on liquid biomarkers, six on innovative imaging, and one on both) focused on RCC diagnosis and fulfilling all the PICOS criteria were included in the qualitative analysis. An additional 56 studies and ten clinical trials focused on either biomarkers for RCC screening (n = 26) or innovative imaging for RCC characterisation (n = 32) were used for supplementary qualitative analyses, despite being excluded.…”

“…A detailed overview of the results of the six studies assessing novel urinary [15,17,20] or serum/plasma [16,18,19] biomarkers for RCC diagnosis is shown in Table 2. Butz et al [15] examined urinary cell-free and exosomal miRNA expression as a noninvasive biomarker.…”

“…Kushlinskii et al [19] analysed plasma expression of KIM, a transmembrane protein involved in innate and adaptive immunity, in patients with ccRCC and those with benign renal tumours. Previous studies suggested that KIM-1 may represent a potential marker for ccRCC diagnosis [93,94].…”

KIM-1 (kidney injury molecule 1) in the urine of renal cell carcinoma patients

“…У больных ПКР, по сравнению со здоровыми лицами, наблюдается достоверное повышение концентрации KIM-1 в плазме крови, коррелирующее с распространенностью опухолевого процесса [3,17]. По данным многоцентрового проспективного когортного исследования EPIC (European Prospective Investigation into Cancer and Nutrition), повышение уровня KIM-1 в плазме крови может служить предиктором риска ПКР, а также фактором плохого прогноза течения заболевания [18].…”