Kidney Injury Molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury

Han, Won Kon; Bailly, Véronique; Abichandani, Rekha; Thadhani, Ravi; Bonventre, Joseph V.

doi:10.1046/j.1523-1755.2002.00433.x

Cited by 1,551 publications

(1,155 citation statements)

References 22 publications

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“…In the past years, besides NGAL, several AKI and DGF biomarkers have been extensively investigated, including urinary KIM‐1, IL‐18, heat shock protein 72 (uHsp72), L‐FABP, calprotectin, CXCL9, CXCL10, CCL2, IL‐18, cystatin C, T‐cell immunoglobulin, and mucin domain‐3 (Tim‐3), tissue inhibitor of metalloproteinase 2 (TIMP‐2), insulin‐like growth factor‐binding protein 7 (IGFBP‐7) 57, 58, 59, 60, 61, 62, 63.…”

Section: Ngal and Other Candidate Biomarkers In Kidney Transplant Setmentioning

confidence: 99%

Neutrophil Gelatinase‐Associated Lipocalin as a Biomarker of Allograft Function After Renal Transplantation: Evaluation of the Current Status and Future Insights

et al. 2017

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Neutrophil gelatinase‐associated lipocalin (NGAL), a protein belonging to the lipocalin superfamily initially found in activated neutrophils, is expressed by several cell types, including kidney tubule. The increase in NGAL production and release from tubular cells in response to various insults has been proven to predict acute kidney injury (AKI). For this reason, it has emerged as a valuable noninvasive biomarker of AKI in clinical nephrology. Also in the renal transplant setting, different studies have indicated NGAL as a valuable tool, especially in the early postoperative period, since the currently available clinical and laboratory parameters remain poorly sensitive to monitor immediate posttransplant graft function. This is an analysis of the recent literature to assess the utility of plasma and urinary NGAL, exosomal mRNA for NGAL, and NGAL levels in the perfusate of machine‐perfused kidneys for the prediction of graft function recovery in the early postsurgery phase after renal transplantation. We found that NGAL appears as a promising troponin‐like biomarker to detect short‐term impairment of graft function after renal transplant, but there are still some limitations in its clinical application, essentially related to its low specificity. Moreover, comparing NGAL assayed in serum, urine, machine‐perfusate, or as exosomal mRNA, each one has shown limitations and benefits in terms of predictive performance for DGF, according to various existing studies, feasibly due to different cut‐off levels, designs and patient sample sizes.

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Section: Ngal and Other Candidate Biomarkers In Kidney Transplant Setmentioning

confidence: 99%

Neutrophil Gelatinase‐Associated Lipocalin as a Biomarker of Allograft Function After Renal Transplantation: Evaluation of the Current Status and Future Insights

et al. 2017

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“…Herein, we observed that only renal Nlrp3 mediates renal dysfunction on the basis of plasma creatinine levels (Supplemental Figure S1, A and B). We next investigated the renal damage markers KIM-1 22 and NGAL 23 to investigate proximal versus distal damage. Both chimeras showed an expression pattern similar to plasma urea and creatinine with respect to KIM-1 ( Figure 2C) and NGAL ( Figure 2D), confirming that both leukocyte-and renalassociated Nlrp3s are detrimental after renal IR injury and indicating that distinct Nlrp3 expression has no differential effect on proximal versus distal tubular damage.…”

Section: Both Renal-and Leukocyte-associated Nlrp3 Mediates Renal Dysmentioning

confidence: 99%

A Tissue-Specific Role for Nlrp3 in Tubular Epithelial Repair after Renal Ischemia/Reperfusion

Bakker

Butter

Claessen

et al. 2014

The American Journal of Pathology

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“…The soluble form of KIM-1 can be easily detected in the urine of patients with AKI and can be used as an important biomarker for tubular injury [19]. In a casecontrol study of 40 children undergoing cardiac surgery, including 20 children with AKI (defined as a 50 % increase in SCr) and 20 without AKI, urinary KIM-1 levels were significantly increased, with an area under the time-concentration curve of 0.83 at the 12-h time-point [20].…”

Section: Kidney Injury Moleculementioning

confidence: 99%

Early markers of obesity-related renal injury in childhood

Ding

Mak

2014

Pediatr Nephrol

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Childhood obesity has become a global epidemic. Recent epidemiological data suggest that obesity is associated with increased risk of renal injury in children. The onset of obesity-associated renal disease is insidious and asymptomatic, so early markers will be extremely useful in its prevention and treatment. Biomarker discovery can be focused on unbiased or biased (candidate) approaches. Unbiased approaches using innovative technologies, such as proteomics and metabolomics, have uncovered candidates that are emerging as plausible biomarkers for such renal disorders as obstructive uropathy and diabetic nephropathy. Biased approaches are based on hypotheses related to glomerular or tubular injury pathophysiology in obesity. Goknar et al. (Pediatric Nephrology 2014; doi: 10.1007/s00467-014-2829 recently evaluated early urine renal injury markers, namely, microalbuminuria, N-acetyl-beta-D-glucosaminidase (NAG), neutrophil gelatinase-associated lipocalin, and kidney injury molecule (KIM)-1, in obese children. They reported that obese children had higher urinary NAG and KIM-1 levels than healthy controls. Longitudinal observation studies are needed to evaluate whether these tubular damage markers are useful as early markers of renal injury in obese children.

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Kidney Injury Molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury

Abstract: A soluble form of human KIM-1 can be detected in the urine of patients with ATN and may serve as a useful biomarker for renal proximal tubule injury facilitating the early diagnosis of the disease and serving as a diagnostic discriminator.

Cited by 1,551 publications

References 22 publications

Neutrophil Gelatinase‐Associated Lipocalin as a Biomarker of Allograft Function After Renal Transplantation: Evaluation of the Current Status and Future Insights

Neutrophil Gelatinase‐Associated Lipocalin as a Biomarker of Allograft Function After Renal Transplantation: Evaluation of the Current Status and Future Insights

A Tissue-Specific Role for Nlrp3 in Tubular Epithelial Repair after Renal Ischemia/Reperfusion

Early markers of obesity-related renal injury in childhood

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