Kidney injury molecule-1 inhibits metastasis of renal cell carcinoma

Lee, Jasper C.; Yotis, Demitra M.; Lee, Ji Yun; Sarabusky, Marie A.; Shrum, Bradly; Champagne, Audrey; Ismail, Ola Z.; Tutunea-Fatan, Elena; Leong, Hon S.; Gunaratnam, Lakshman

doi:10.1038/s41598-021-90919-8

Cited by 5 publications

(6 citation statements)

References 35 publications

(35 reference statements)

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“…KIM1, a type-I cell surface glycoprotein, negatively correlated with creatinine. As an acute marker of early acute kidney injury, KIM1 is predictive of long-term renal outcome [97] and is reported to have protective functions in renal ischemia-reperfusion injury, promote renal graft recovery, have a role in renal cancer pathophysiology and serve as a biomarker for sepsis-induced acute kidney injury [98][99][100][101][102]. The tumor necrosis and transforming growth factor protein families have well-known roles in cellular migration, growth, differentiation, and tissue repair [103], as well as critical roles in mediating the cytokine storm in sepsis [104].…”

Section: Discussionmentioning

confidence: 99%

Novel plasma protein biomarkers from critically ill sepsis patients

et al. 2022

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Background Despite the high morbidity and mortality associated with sepsis, the relationship between the plasma proteome and clinical outcome is poorly understood. In this study, we used targeted plasma proteomics to identify novel biomarkers of sepsis in critically ill patients. Methods Blood was obtained from 15 critically ill patients with suspected/confirmed sepsis (Sepsis-3.0 criteria) on intensive care unit (ICU) Day-1 and Day-3, as well as age- and sex-matched 15 healthy control subjects. A total of 1161 plasma proteins were measured with proximal extension assays. Promising sepsis biomarkers were narrowed with machine learning and then correlated with relevant clinical and laboratory variables. Results The median age for critically ill sepsis patients was 56 (IQR 51–61) years. The median MODS and SOFA values were 7 (IQR 5.0–8.0) and 7 (IQR 5.0–9.0) on ICU Day-1, and 4 (IQR 3.5–7.0) and 6 (IQR 3.5–7.0) on ICU Day-3, respectively. Targeted proteomics, together with feature selection, identified the leading proteins that distinguished sepsis patients from healthy control subjects with ≥ 90% classification accuracy; 25 proteins on ICU Day-1 and 26 proteins on ICU Day-3 (6 proteins overlapped both ICU days; PRTN3, UPAR, GDF8, NTRK3, WFDC2 and CXCL13). Only 7 of the leading proteins changed significantly between ICU Day-1 and Day-3 (IL10, CCL23, TGFα1, ST2, VSIG4, CNTN5, and ITGAV; P < 0.01). Significant correlations were observed between a variety of patient clinical/laboratory variables and the expression of 15 proteins on ICU Day-1 and 14 proteins on ICU Day-3 (P < 0.05). Conclusions Targeted proteomics with feature selection identified proteins altered in critically ill sepsis patients relative to healthy control subjects. Correlations between protein expression and clinical/laboratory variables were identified, each providing pathophysiological insight. Our exploratory data provide a rationale for further hypothesis-driven sepsis research.

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Section: Discussionmentioning

confidence: 99%

Novel plasma protein biomarkers from critically ill sepsis patients

et al. 2022

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“…The innovation of gene editing technologies has significantly reduced the time needed to establish a GEMM ( 34 ). GEMM has been used in the study of colorectal cancer ( 35 ), renal cell carcinoma ( 36 ) and breast cancer ( 37 ). In addition, it can be used in preclinical trials for hormonal and targeted therapies as well as immunotherapy.…”

Section: Tumor Mouse Modelmentioning

confidence: 99%

Obesity and cancer: Mouse models used in studies

Zhang

Wang

et al. 2023

Front. Oncol.

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There is increasing evidence that obesity is associated with the occurrence and development of malignant tumors. When studying the relationship between obesity and malignant tumors, it is very important to choose an appropriate animal model. However, BALB/c nude mice and other animals commonly used to study tumor xenograft (human-derived tumor cell lines) transplantation models are difficult to induce obesity, while C57BL/6 mice and other model animals commonly used for obesity research are not suitable for tumor xenograft transplantation. Therefore, it is difficult to replicate both obesity and malignancy in animal models at the same time. This review summarizes several experimental animal models and protocols that can simultaneously induce obesity and tumor xenografts.

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“…The time to metastatic relapse is variable, usually several years after surgical treatment. Our case report has an early filing of 4 months, which is below the average (24 months) in a series of cases [1] and for other case reports [2,[7][8][9], also the initial size of the mass is unusual with a commitment of 100% of the lumen, which is greater than the reported cases, where a solitary nodule or polyp is generally reported that does not occupy the entire esophageal diameter [2,9,10], the treatment is multidisciplinary, with surgical treatment as the first option and a combination of radiotherapy and chemotherapy [8,9], with the increasingly widespread use of tyrosine kinase inhibitors such as pazopanib [2][3][4][5][6], or checkpoint inhibitors.…”

Section: Ccrc: Clear Cell Renal Cell Carcinomamentioning

confidence: 99%

“…The metastases secondary to clear cell renal cell carcinomas (CCRC) are present in approximately 30% of patients with advanced stages and this is associated with <15% 5-year survival [ 3 ]. The most common sites of metastasis are the lungs (70%) and bone (32%), on the other hand, the less frequent metastases are thyroid (0.7%) and gastric (0-7%), which represent <5% of the metastases of CCR [ 4 - 5 ].…”

Section: Introductionmentioning

confidence: 99%

Early Metastasis of Clear Cell Renal Cell Carcinoma to the Esophagus: A Case Report

Quintero¹,

Cabezas²,

Hidalgo³

et al. 2023

Cureus

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Metastatic involvement of clear cell renal cancer in the esophagus has been described in the literature as an uncommon condition. These usually present as late relapse causing clinical manifestations such as dysphagia and melena. We present the case of a 57-year-old man with a history of renal cell carcinoma who presented an early metastasis to the esophagus. In addition, we made a comparison of the reason for examination, time of relapse, and metastasis in other anatomical places of all the cases reported in the literature of esophageal involvement due to clear cell metastasis.

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Kidney injury molecule-1 inhibits metastasis of renal cell carcinoma

Cited by 5 publications

References 35 publications

Novel plasma protein biomarkers from critically ill sepsis patients

Novel plasma protein biomarkers from critically ill sepsis patients

Obesity and cancer: Mouse models used in studies

Early Metastasis of Clear Cell Renal Cell Carcinoma to the Esophagus: A Case Report

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