Kidney Injury Molecule-1 in the detection of early kidney injury in dogs with leptospirosis

Dias, Camila Carneiro; Paz, Lucas Nogueira; Solcà, Manuela da Silva; Portela, Ricardo Wagner; Bittencourt, Marta Vasconcelos; Pinna, Melissa Hanzen

doi:10.1016/j.cimid.2021.101637

Cited by 8 publications

(6 citation statements)

References 48 publications

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“…A cross-sectional study by Nisansala et al found elevated urine KIM-1 levels in patients with leptospirosis related AKI 28 . Another cross-sectional study on naturally infected dogs by Dias et al showed an association between high levels of urine KIM-1 and AKI as well as evidence that KIM-1 is an early marker of kidney injury 29 .…”

Section: Resultsmentioning

confidence: 97%

Kidney Injury Biomarkers in Leptospirosis

Uribe-Restrepo

Muñoz-Zanzi

Agudelo‐Flórez

2023

Rev. Soc. Bras. Med. Trop.

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Leptospirosis is a zoonotic infection with a global distribution, though it has a greater impact on marginalized rural agricultural and urban communities in developing countries. Kidney injury, which can lead to severe and lethal infections, is the most frequent complication associated with leptospirosis. Novel biomarkers are being studied as tools for assessing kidney injury in different pathological processes to improve early detection. This review aimed to gather information on the use of novel kidney biomarkers for human leptospirosis. A search of the literature was carried out in September 2021 using the parameters “((kidney) OR (renal) OR (chronic kidney disease) OR (acute kidney injury)) AND ((biomarker) OR (marker)) AND (( Leptospira ) OR (leptospirosis))”. The review identified 11 original studies that evaluated the performance of 15 kidney biomarkers related to leptospirosis. Assessment of the evidence for biomarker utility was limited because of the small number of studies and sample sizes. Although some biomarkers were associated with kidney disease, no specific biomarker appeared to be ready for clinical practice, and more research in this field is necessary.

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Section: Resultsmentioning

confidence: 97%

Kidney Injury Biomarkers in Leptospirosis

Uribe-Restrepo

Muñoz-Zanzi

Agudelo‐Flórez

2023

Rev. Soc. Bras. Med. Trop.

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“…The canine model presents a unique opportunity to study dehydration-induced renal damage. Assessing KIM-1 levels in the urine of canine patients successfully identified tubular injury during the initial stages of non-azotemic infections [13].…”

Section: Introductionmentioning

confidence: 99%

Early Detection of Renal Damage Using Kidney Injury Molecule -1 (KIM-1) In Dogs Associated with Dehydration

Ryad,

Ramadan,

El khiat

et al. 2025

Egyptian Journal of Veterinary Sciences

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B ACKGROUND: Dehydration may be associated with a declined kidney function and serious signs of kidney injury. The kidney response differently to dehydration levels which are not yet known. Aim: detection of the effect of dehydration on kidney functions levels and kidney injury biomarkers in dehydrated dogs and compare it to normal. Material and methods: A total number of 12 dogs were enrolled in this study (6 dehydrated and 6 controls). Inclusion criteria was presence of history of fluid loss for 48-hour, dehydration stage based on clinical assessment and the assessment of urine specific gravity. Blood samples were withdrawn from each animal on Ethylenediamine tetraacetic acid tube for hematology and plain tube to estimate total protein, albumin, BUN and creatinine. Ultrasonography was conducted on non-sedated dogs using a micro convex 5-8 MHz transducer. Urine samples were acquired through catheterization to determine urine specific gravity, then urine sediment was derived by centrifugation and commercially available Enzyme-linked immunoassay test was utilized to assess the levels of kidney injury molecule-1. Results: Hematological parameters showed nonsignificant elevation in packed cell volume in association with significant elevation in mean corpuscular volume were recorded in dehydrated dogs. Non-significant elevation in blood urea nitrogen, creatinine, and total protein were recorded in dehydrated dogs compared with control dogs. Urinalysis showed significant elevation in urine specific gravity and KIM-1 (P value ≤0.05) in urine samples of dehydrated dogs compared to control dogs. Conclusion, dehydration state might be impact the reading of urinary KIM-1 even in the absence of apparent azotemia.

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“…Kidney injury molecule‐1 (KIM‐1) is another well‐established marker of tubular injury. Its expression is low in normal kidneys, 16 but increases substantially with tubular injury, therefore KIM‐1 is a potential diagnostic marker for AKI in human patients and in dogs 16‐22 …”

Section: Introductionmentioning

confidence: 99%

“…Its expression is low in normal kidneys, 16 but increases substantially with tubular injury, therefore KIM-1 is a potential diagnostic marker for AKI in human patients and in dogs. [16][17][18][19][20][21][22] Since presence of injury markers have been documented in animals with CKD, it is possible that monitoring these injury markers will allow identification of active kidney damage in animals with CKD, and animals prone to rapid CKD progression. This will facilitate closer monitoring and timely therapeutic intervention.…”

Section: Introductionmentioning

confidence: 99%

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Short‐term intra‐individual variation of urinary biomarkers in dogs with stable chronic kidney disease

Chen

Maron

Segev

2023

Veterinary Internal Medicne

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Background Active‐ongoing kidney damage is present in animals with stable chronic kidney disease (CKD), as reflected by biomarkers in urine. Interpretation of serial messurements of biomarkers requires knowledge of its intra‐individual variation. Aims To evaluate the short‐term intra‐individual variation of urinary neutrophil gelatinase‐associated lipocalin and kidney injury molecule‐1 (uNGAL, uKIM‐1, respectively) in dogs with stable CKD, and to determine whether normalization to urinary creatinine (uCr) decreases variation. Animals Twenty‐five dogs with naturally‐occurring stable CKD. Methods Prospective, observational study. Dogs were diagnosed with CKD based on the International Renal Interest Society guidelines. Dogs were included only if the variation in serum creatinine concentration was <25% on at least 2 measurements during the 3 months preceding inclusion, and only if serum creatinine variation was <20% during the 14‐day study period. Urine samples were collected on days 0, 4, 10 and 14. uNGAL and uKIM‐1 were measured using ELISA. Results The median coefficients of variation (CV) of uNGAL and uNGAL/uCr were 42% (range, 7%‐127%), and 44% (range, 8%‐100%), respectively, and the CV 90th percentiles were 97% and 83%, respectively. The median CV of uKIM‐1 and uKIM‐1/uCr were 29% (range, 16%‐91%), and 23% (range, 6%‐76%), respectively, and the CV 90th percentiles were 56% and 52%, respectively. Conclusions and Clinical Importance Changes of >100% and >60% for uNGAL and uKIM‐1, respectively, in serial measurements are higher than the normal expected variation and therefore might indicate need for further investigation for underlying causes of kidney damage.

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Kidney Injury Molecule-1 in the detection of early kidney injury in dogs with leptospirosis

Cited by 8 publications

References 48 publications

Kidney Injury Biomarkers in Leptospirosis

Kidney Injury Biomarkers in Leptospirosis

Early Detection of Renal Damage Using Kidney Injury Molecule -1 (KIM-1) In Dogs Associated with Dehydration

Short‐term intra‐individual variation of urinary biomarkers in dogs with stable chronic kidney disease

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