Kidney inflammation and tissue injury induced by scorpion venom: comparison with a nephrotoxic model

Saidani, Chanez; Béchohra, Louisa; Laraba-Djebari, Fatima; Hammoudi-Triki, Djelila

doi:10.1080/15569543.2018.1446028

Cited by 9 publications

(5 citation statements)

References 50 publications

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“…This finding coheres with previous reports exhibiting a direct/indirect nephrotoxic outcome by the venom because, besides the information on last paragraph, it also produces the release of many modulators and mediators such as neurotransmitters, cytokines; oxygen-free radicals, and lipidic solutions [46][47][48]. This development is present in C. margaritatus [49], Hottentota gentili [50]; T. nororientalis [51], Androctonus australis hector [46]; Androctonus liouvillei [47], and T. caripintensis [48], along other specimens from the Buthidae family.…”

Section: Discussionsupporting

confidence: 92%

Comparison of the Scorpionism Caused by Centruroides margaritatus, Tityus pachyurus and Tityus n. sp. aff. metuendus Scorpion Venoms in Colombia

Mendoza-Tobar

Meza-Cabrera

Sepúlveda-Arias

et al. 2021

Toxins

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Among other scorpion species, Colombia has two genera of the Buthidae family Centruroides and Tityus, considered to be dangerous to humans. This research shares scientific knowledge aiming to a better understanding about the pathophysiological effects of such venoms. The venom of the three species: Centruroides margaritarus, Tityus pachyurus, and T. n. sp. aff. metuendus with biomedical interest were studied. An initial pre-glycemic sample was taken from ICR mice. They were later intraperitoneally inoculated with doses of 35% and 70% of LD50 of total venom. Poisoning signs were observed during a 6-h period to determine the level of scorpionism. After observation, a second glycemic sample was taken, and a histopathological evaluation of different organs was performed. This work revealed that all three venoms showed considerably notorious histopathological alterations in main organs such as heart and lungs; and inducing multiple organ failure, in relation to the glycemia values, only C. margaritatus and T. n. sp. aff. metuendus showed significant changes through manifestation of hyperglycemia. According to the Colombian scorpionism level; signs were mild to severe affecting the autonomous nervous system.

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Section: Discussionsupporting

confidence: 92%

Comparison of the Scorpionism Caused by Centruroides margaritatus, Tityus pachyurus and Tityus n. sp. aff. metuendus Scorpion Venoms in Colombia

Mendoza-Tobar

Meza-Cabrera

Sepúlveda-Arias

et al. 2021

Toxins

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“…The mice group treated with dexamethasone resulted in lower levels of AST and ALT yet it was not comparable to the A. Indica extract treatment showed highly diminished levels of AST and ALT suggesting that the liver damage was controlled in more proportion to administration of A. indica. The inflammation was confirmed by observing the enhanced activity of EPO, a marker of eosinophilic inflammation (Saidani et al, 2019). In this study, the activity of EPO enhanced in smoke-induced mice was suppressed on administration of A. indica extract at both doses and perhaps the bioactive compounds of A. indica were responsible for the anti-inflammatory effect.…”

Section: Discussion Discussion Discussionsupporting

confidence: 58%

Protective effect of neem leaf extract and dexamethasone in cigarette-smoke induced liver and kidney injury in Swiss mice: A comparative analysis

VERMA,

SUBHASHINI,

SRIVASHTAV

et al. 2024

Not Sci Biol

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Cigarette smoke (CS) is one of the leading causes of lung injury where co-morbidity in different organs including liver and kidney can be observed. CS contributes as one of the causes of mortality across the globe. Dexamethasone, a corticosteroid is widely used as an anti-inflammatory medication despite being associated with several side effects with long-term usage. Therefore, the present study focused on the comparison between dexamethasone and Azadirachta indica leaf extract (AILE) for treating hepatic and renal injury caused by CS in mice. The phytochemical screening of AILE revealed the abundance of phytocompounds as sterols, proteins, alkaloids, flavonoids and diterpenes that might have antioxidant and anti-inflammatory activity. In this context, Swiss mice were treated with CS, dexamethasone and AILE. CS-induced mice expressed elevated inflammatory cells, Reactive Oxygen Species (ROS) with higher levels of both liver and kidney function markers: Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and creatinine respectively which was reversed by AILE. No mortality was observed in CS or AILE-treated group while dexamethasone-treated mice exclusively resulted in 20% mortality. Moreover, CS-induced mice also exhibited declined SOD levels in the liver and kidney and higher Eosinophil peroxidase (EPO) which was modulated by AILE treatment. This is the first report demonstrating in vivo the effects of A. indica ethanolic leaf extract in treating CS-induced hepatic and renal chronic inflammation in an animal model which gave better results when compared to dexamethasone.

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“…The toxicity of Hemiscorpius lepturus scorpion venom to renal parenchyma induced signs of the damaged tubule, renal glomerulus 43 besides tubular inflammatory cell infiltration and hemorrhage by injection of Androctonus australis hector scorpion venom. 44 The neurological symptoms induced by the Am and Bo venoms are mostly related to nervous structures. These symptoms are observed after 60 min of envenomation, which were positively correlated to the time where severe damages in the brain tissue were detected.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Induced pathophysiological alterations by the venoms of the most dangerous Moroccan scorpions Androctonus mauretanicus and Buthus occitanus: A comparative pathophysiological and toxic-symptoms study

et al. 2022

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Scorpion envenomation is a serious public health issue. Androctonus mauretanicus ( Am) and Buthus occitanus ( Bo) are the most dangerous scorpions in Morocco. Despite their medical relevance, no study has yet related their kinetics of symptom apparition and the consequent tissue disorders at the same interval post-injection. This work achieved the first comparative pathophysiological and toxic-symptoms study between the Am and Bo venoms from a biochemical, toxicological and physiopathological standpoint. The activity of venoms and their subletal dose were determined by administration of increasing concentrations of the venoms. 30, 60 and 120 min following the experimental envenomation in mice, the profile of clinical symptoms was underlined and the main organs: brain, heart, lungs, liver and kidneys were removed for histological examination. The Am venom is a rich source of proteins and three-times more toxic than the Bo. The most observed clinical symptoms are neurological and cardiopulmonary. The Am venom caused histopathological alterations at 30, 60, and 120 min which were more important than the Bo. This study highlighted that both venoms exhibited a strong toxicity with variable intensities. Moreover, we showed the presence of correlation between the level of histopathological disorders observed and the intensity of signs appeared at the same time following venom inoculation.

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Kidney inflammation and tissue injury induced by scorpion venom: comparison with a nephrotoxic model

Cited by 9 publications

References 50 publications

Comparison of the Scorpionism Caused by Centruroides margaritatus, Tityus pachyurus and Tityus n. sp. aff. metuendus Scorpion Venoms in Colombia

Comparison of the Scorpionism Caused by Centruroides margaritatus, Tityus pachyurus and Tityus n. sp. aff. metuendus Scorpion Venoms in Colombia

Protective effect of neem leaf extract and dexamethasone in cigarette-smoke induced liver and kidney injury in Swiss mice: A comparative analysis

Induced pathophysiological alterations by the venoms of the most dangerous Moroccan scorpions Androctonus mauretanicus and Buthus occitanus: A comparative pathophysiological and toxic-symptoms study

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