Kidney growth and renal functions under the growth hormone replacement therapy in children

Ece, Aydın; Çeti̇nkaya, Semra; Ekşioğlu, Seçil; Şenel, Saliha; Özkasap, Serdar; Giniş, Tayfur; Şen, Velat; Şahin, Cahit

doi:10.3109/0886022x.2013.875834

Cited by 14 publications

(16 citation statements)

References 22 publications

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“…Similar to the current study, a previous study [24] reported non-significant differences in weight values between GH deficient patients and the control. In contrast, the present result disagrees with that of a previous investigation [25]. The reason for the discrepancies between the studies may be related to the sample size,nutritional habits and life style factors.…”

Section: Anthropometric Measurements Of Ghdeficient Patients and The contrasting

confidence: 99%

“…Concerning the present results of BMI,they are similar to those of other studies [24,25] which reported non-significant differences in BMI between the GH deficient patients and the control group,while theyare indisagreement with other reports [29] . The reason might be that BMI depends on the weight and height and thatit is not clear whether there is a similar association between BMI and peak GH level in healthy children [24].…”

Section: Anthropometric Measurements Of Ghdeficient Patients and The supporting

confidence: 92%

“…These studies stated that GHD in pubertyis not associated with metabolic abnormalities that are known to cause osteopenia. It has been reported that intestinal calcium absorption, serum calcium and phosphorus levels as well as bone formation activity were normal in patients with GHD [41].Regarding the urea and creatinine levels, the present findings are similar to those of a previous study [25]which reported no significant differences in serum urea and creatinine. This may be caused by any chronic disease, but not GHD, which would lead to delay of growth, chronic renal failure are often associated with short stature [34].…”

Section: Biochemical Parameters Of the Gh Deficient Patients And Contsupporting

confidence: 91%

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Evaluation of Calcium Regulating Hormones and Some Biochemical Parameters in Growth Hormone Deficient Patients

Aldabagh

Al-Lami

Al-Samarriae

2020

eijs

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The present study aims to evaluate levels of calcium regulating hormones and some biochemical parameters in a sample of growth hormone (GH) deficient patients. Seventy five GH deficient patients and twenty healthy subjects used as a control group have been involved in this study during their attendance at the National Diabetic Centerfor Treatment and Research /Al-Mustansiriya University. The studied subjects were in an age range of 3-15 years. Blood samples were collected from the studied subjects to determine levels of basal GH,GH 2. and GH 3 after 60 mins. and 90mins. of provocation with clonidine. The study also included the measurement of the levels of insulin like growth factor (IGF-1); calcium regulating hormones [parathyroid hormone (PTH) and vitamin D],and some biochemical parameters [calcium (Ca), phosphorus (P), urea, and creatinine].Distribution of the studied groups according to gender revealed that most of the GH deficientpatients (60 %) were males while 40 % were females,with the difference being statistically significant (P<0.05), while the control included two equal subgroups (50 % males and 50 % females). Distribution of the studied groups according to BMI values showed that the percentage of underweight was significantly (P<0.01) higher in the patients (48%) compared to the control (10%), while the percentage of normal weight was significantly (P<0.01) higher in the control (85%) as compared to the patients (40%).The results showed highly significant decreases (P<0.01) in the levels of basal GH, GH 2 and GH 3 in the patients as compared to the control group. Also, IGF-1 levels showed a high significant (P<0.01) decrease in the patients as compared to the control group.The findings of calcium regulating hormones revealed non-significant differences in the levels of PTH and vitamin D between the patients and the control group. Also, the results of the biochemical parameters (Ca, P, urea, and creatinine) showed non-significant differences in their values between the patients and the control group.It can be concluded from the present study that GH deficiency (GHD) seems to be dominating in the males under weighted patients. The diagnosis of GHD cannot be achieved at the basal GH level.IGF-1 is a reliable marker of GH functions. Finally, levels of calcium regulating hormones are not affected by GHD.

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Section: Anthropometric Measurements Of Ghdeficient Patients and The contrasting

confidence: 99%

Section: Anthropometric Measurements Of Ghdeficient Patients and The supporting

confidence: 92%

Section: Biochemical Parameters Of the Gh Deficient Patients And Contsupporting

confidence: 91%

See 1 more Smart Citation

Evaluation of Calcium Regulating Hormones and Some Biochemical Parameters in Growth Hormone Deficient Patients

Aldabagh

Al-Lami

Al-Samarriae

2020

eijs

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“…Although both growth hormone (produced by the anterior pituitary gland) and insulin-like growth factor 1 are growth stimulants for many organs, including kidney, 10,21,67 a key question is why these hormones might be retained after transplantation in the kidney but not the heart, which, in the abdominal heterotopic position, apparently does not continue to grow rapidly. 37,[48][49][50] The fact that the kidney grafts are life-supporting, whereas heterotopic (that is, abdominally placed) heart grafts do not support a vascular circulatory system (and therefore are not fully functional), may be relevant.…”

mentioning

confidence: 99%

Physiologic Aspects of Pig Kidney Transplantation in Nonhuman Primates

2018

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Xenotransplantation can provide a solution to the current shortage of human organs for patients with terminal renal failure. The increasing availability of genetically engineered pigs, effective immunosuppressive therapy, and antiinflammatory therapy help to protect pig tissues from the primate immune response and can correct molecular incompatibilities. Life-supporting pig kidney xenografts have survived in NHP for more than 6 mo in the absence of markers of consumptive coagulopathy. However, few reports have focused on the physiologic aspects of life-supporting pig kidney xenografts. We have reviewed the literature regarding pig kidney xenotransplantation in NHP. The available data indicate (1) normal serum creatinine, (2) normal serum electrolytes, except for a trend toward increased calcium levels and a transient rise in phosphate followed by a fall to slightly subnormal values, (3) minimal or modest proteinuria without hypoalbuminemia (suggesting that previous reports of proteinuria likely were due to a low-grade immune response rather than physiologic incompatibilities), (4) possible discrepancies between pig erythropoietin and the primate erythropoietin receptor, and (5) significant early increase in kidney graft size, which might result from persistent effects of pig growth hormone. Further study is required regarding identification and investigation of physiologic incompatibilities. However, current evidence suggests that, in the absence of an immune response, a transplanted pig kidney likely would satisfactorily support a human patient.

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“…[4][5][6] Also, in GH deficient children, GH treatment has been shown to increase kidney length and total kidney volume. [7][8][9][10] It is essential to ascertain longitudinal data after cessation of GH treatment, to investigate the possible effects of higher serum IGF-I levels during childhood on GFR in adulthood.…”

Section: Introductionmentioning

confidence: 99%

Glomerular filtration rate, blood pressure and microalbuminuria in adults born SGA: A 5‐year longitudinal study after cessation of GH treatment

Goedegebuure¹,

Kerkhof²,

Hokken-Koelega³

2019

Clinical Endocrinology

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Background: Growth hormone treatment increases glomerular filtration rate (GFR), as serum IGF-I stimulates the renin-angiotensin system. Infants born with a low birth weight have a smaller number of nephrons, which cause a lower GFR, a higher blood pressure and a higher albumin-to-creatinine ratio in early adulthood. Method:A total of 261 young adults born SGA, previously treated with growth hormone (SGA-GH), were longitudinally followed. Glomerular filtration rate, based on serum creatinine levels, was determined at cessation of GH treatment and at 6 months, 2 years and 5 years thereafter. Glomerular filtration rate, blood pressure and urinary albumin-to-creatinine ratio at 5 years after cessation of GH were compared with untreated age-matched controls (56 untreated short subjects born SGA [SGA-S], 118 subjects born SGA with spontaneous catch-up growth [SGA-CU], 135 subjects born appropriate for gestational age [AGA]).Results: Glomerular filtration rate decreased significantly only during the first 6 months after cessation of GH treatment, while remaining well within the normal range (124.6 vs 120.2 mL/min/1.73 m 2 , P < .001). SGA-GH adults had a similar GFR, blood pressure and urinary albumin-to-creatinine ratio as the healthy controls born SGA and AGA. Conclusion:In conclusion, our 5 years longitudinal follow-up study shows a decrease in GFR during 6 months after GH cessation, but thereafter GFR remained stable and within the normal range. Glomerular filtration rate, blood pressure and urinary albumin-to-creatinine ratio at 21 years of age were similar in GH-treated young adults born SGA and untreated controls born SGA or AGA. We conclude that long-term GH treatment in children born SGA has no unfavourable effects on kidney function in early adulthood. Précis:We present a longitudinal study on kidney function in the follow-up of growth hormone-treated young adults who were born small for gestational age. K E Y W O R D Sgrowth hormone, kidney function, microalbuminuria, SGA | 893 GOEDEGEBUURE Et al.

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Kidney growth and renal functions under the growth hormone replacement therapy in children

Cited by 14 publications

References 22 publications

Evaluation of Calcium Regulating Hormones and Some Biochemical Parameters in Growth Hormone Deficient Patients

Evaluation of Calcium Regulating Hormones and Some Biochemical Parameters in Growth Hormone Deficient Patients

Physiologic Aspects of Pig Kidney Transplantation in Nonhuman Primates

Glomerular filtration rate, blood pressure and microalbuminuria in adults born SGA: A 5‐year longitudinal study after cessation of GH treatment

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