2005
DOI: 10.1093/bja/aei018
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Kidney dysfunction in the postoperative period

Abstract: The development of perioperative acute renal failure is associated with a high incidence of morbidity and mortality. Although this incidence varies with different surgical procedures and with the definition used for renal failure, we now understand better the aetiology of the underlying problem. However, successful strategies to provide renal protection or strategies for 'rescue therapy' are either lacking, unsubstantiated by randomized clinical trials, or show no significant efficacy. The present review consi… Show more

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Cited by 252 publications
(173 citation statements)
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References 98 publications
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“…Glomerular function declines with age, but studies show that renal failure during heart surgery is a frequent complication; noted more often when CPB time exceeds 90 minutes, confirming the findings of the sample [26][27][28].…”
Section: Discussionsupporting
confidence: 71%
“…Glomerular function declines with age, but studies show that renal failure during heart surgery is a frequent complication; noted more often when CPB time exceeds 90 minutes, confirming the findings of the sample [26][27][28].…”
Section: Discussionsupporting
confidence: 71%
“…[13,17,18] Because there was no increase in its levels, we can assume that there was no clinically significant decrease in GFR during the study period in either group. The Cochrane meta-analysis of effects of nonsteroidal anti-inflammatory drugs on postoperative renal function in adults with normal renal function did not find any clinically meaningful difference between NSAIDs and placebo.…”
Section: Discussionmentioning
confidence: 90%
“…Severe renal hypoperfusion, if not corrected, will ultimately lead to ischemic ATN 8 . The oxygen tension in the renal cortex is about 50 mmHg higher than that of the inner medulla, as a result of heterogeneity of flow and oxygen requirement 9 . Medullary oxygenation is strictly balanced by a series of control mechanisms, which match regional oxygen supply and consumption.…”
Section: Discussionmentioning
confidence: 99%
“…Ht was studied in Ml and M4. For each attributes the Profile Analysis was performed 9 . The histological data were also analyzed (Mann-Whitney proof).…”
Section: Discussionmentioning
confidence: 99%