Kidney dysfunction as a risk factor for first symptomatic stroke events in a general Japanese population--the Ohasama study

Nakayama, Masaaki; Metoki, Hirohito; Terawaki, Hiroyuki; Ohkubo, Takayoshi; Kikuya, Masahiro; Sato, Toshinobu; Nakayama, Keiichi I.; Asayama, Kei; Inoue, Ryusuke; Hashimoto, Junichiro; Totsune, Kazuhito; Hoshi, Hiroyuki; Ito, Sadayoshi; Imai, Yutaka

doi:10.1093/ndt/gfm051

Cited by 188 publications

(122 citation statements)

References 18 publications

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“…Renal dysfunction is an independent risk factor for death and/or cardiovascular disease (CVD) events among the general population [1,2]. Although the reason why renal dysfunction increases CVD mortality and morbidity is unclear, the accumulated evidence suggests the major participation of oxidative stress (OS) [3].…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Xanthine Oxidoreductase and Xanthine Oxidase Activities in Plasma and Kidney Dysfunction

Terawaki¹,

Murase²,

Nakajima³

et al. 2017

J Clin Exp Nephrol

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Background: Oxidative stress (OS) is thought to play a role in detrimental events among patients with chronic kidney disease (CKD). Although the mechanism of OS increases in CKD patients is unclear, it has been suggested that increased activity of xanthine oxidase (XO), the superoxideproducing form of xanthine oxidoreductase (XOR), plays a large role in enhancing OS. Therefore, we measured the activities of plasma XOR and XO among CKD patients.

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Section: Introductionmentioning

confidence: 99%

The Relationship between Xanthine Oxidoreductase and Xanthine Oxidase Activities in Plasma and Kidney Dysfunction

Terawaki¹,

Murase²,

Nakajima³

et al. 2017

J Clin Exp Nephrol

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“…Accumulative evidence has revealed that a decreased glomerular filtration rate (GFR) and the presence of proteinuria are independent risk factors for death and/or cardiovascular disease (CVD) events among general populations (1)(2)(3). Thus, it is now recognized that chronic kidney disease (CKD) (4) is an emerging new target for investigation from the viewpoint of public health.…”

Section: Introductionmentioning

confidence: 99%

Masked Hypertension Determined by Self-Measured Blood Pressure at Home and Chronic Kidney Disease in the Japanese General Population: The Ohasama Study

et al. 2008

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, Takayoshi OHKUBO 4), 5) , Masahiro KIKUYA 6) , Kei ASAYAMA 4), 5) , Ryusuke INOUE 5) , Haruhisa HOSHI 7) , Sadayoshi ITO 1) , and Yutaka IMAI 59.6 mL/min, and 57.3 mL/min for CCr, 4.2%, 8.9%, 10.3%, and 12.8% for the prevalence of positive proteinuria, and 2.3%, 3.0%, 6.3%, and 9.8% for the proportion with CCr <60 mL/min with proteinuria. Compared with the SNBP group, the MHT and SHT groups exhibited significant differences in these parameters (p <0.05, for each). The adjusted odds ratios for CCr <60 mL/min with proteinuria were significantly higher in the MHT (2.56) and SHT (3.60) groups compared with the SNBP group (reference IntroductionAccumulative evidence has revealed that a decreased glomerular filtration rate (GFR) and the presence of proteinuria are independent risk factors for death and/or cardiovascular disease (CVD) events among general populations (1-3). Thus, it is now recognized that chronic kidney disease (CKD) (4) is an emerging new target for investigation from the viewpoint of public health. Hypertension, a classic risk factor for CVD events, can be clinically classified into subgroups: sustained hypertension (SHT), white-coat hypertension (WCHT), and masked hypertension (MHT) (5), which is characterized by normal casual blood pressure (CBP) and elevated home blood pressure (HBP) or ambulatory blood pressure (BP) levels. Among the subtypes, it has been revealed that patients with MHT are at a high risk for CVD morbidity and mortality similar to that of patients with SHT (6, 7). Accordingly, it is clinically important to clarify the relationship between CKD and MHT in terms of screening high-risk populations and targeting therapeutic levels of BP in CKD patients; however, little is known regarding this issue.The present cross-sectional study examined the CKD incidence in subjects with MHT in the Japanese general population. Methods DesignThis study was a part of the Ohasama study, a longitudinal BP measurement project initiated in 1986. The socio-economic and demographic characteristics of this region and full details of the project have been described previously (8). The study was approved by the Institutional Review Board of Tohoku University School of Medicine and the Department of Health of the Ohasama Town Government. Study PopulationIn Japan, annual health checkups are available for farmers, the self-employed, retirees, and dependents aged ≥ 35 years. Among the 7,496 residents of Ohasama, 3,076 were eligible for annual health checkups in 1992. A total of 2,192 residents participated in checkups from 1992 to 1997. Of the 2,192 participants, 215 were excluded due to missing serum creatinine levels, missing dipstick tests for spot-urine, and other confounding factors (age, gender, body mass index [BMI], current smoking, diabetes mellitus, hypercholesterolemia, antihypertensive treatment, and history of CVD). Participants who were hospitalized, mentally ill, or bedridden were also excluded (n= 185). In addition, participants with less than 14 d of HBP measurements and participan...

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“…3,4 A number of prospective studies have also disclosed CKD as a risk factor for another vascular disease: Stroke. [5][6][7] In the Rotterdam study, having CKD was a risk factor for only hemorrhagic but not for ischemic stroke. 8 A recent study showed sex difference as a risk factor in CKD that was associated with hemorrhagic stroke in men but ischemic stroke in women.…”

Section: Introductionmentioning

confidence: 99%

CKD is associated with recurrent ischemia but not with hemorrhagic transformation in acute ischemic stroke patients

Micozkadıoğlu¹,

Özelsancak²,

Gıray

et al. 2013

Renal Failure

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Background: We investigated the associations of Recurrent Ischemic Stroke (RIS) and Hemorrhagic Transformation (HT) with CKD in acute ischemic stroke patients. Method: The subjects were 160 patients, divided into two groups: with eGFR 560 mL/min/1.73 m 2 (CKD), with eGFR !60 mL/min/1.73 m 2 (without CKD). Results: Subjects having DM (p ¼ 0.018), CKD (p ¼ 0.025) and treated with ACEI/ARB (p ¼ 0.039) revealed association with RIS. Regression analysis disclosed only CKD (p ¼ 0.04). Carotid artery stenosis (p ¼ 0.030) and serum calcium levels (p ¼ 0.013) showed significant association with HT. Conclusion: Our results disclosed that CKD could be a risk factor for RIS. There is no relation between CKD and HT.

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Kidney dysfunction as a risk factor for first symptomatic stroke events in a general Japanese population--the Ohasama study

Abstract: Decreased kidney function increased the risk of first symptomatic stroke events in a general Japanese population. The high prevalence of stroke in this population prompts the need for greater public awareness about risks for CKD.

Cited by 188 publications

References 18 publications

The Relationship between Xanthine Oxidoreductase and Xanthine Oxidase Activities in Plasma and Kidney Dysfunction

The Relationship between Xanthine Oxidoreductase and Xanthine Oxidase Activities in Plasma and Kidney Dysfunction

Masked Hypertension Determined by Self-Measured Blood Pressure at Home and Chronic Kidney Disease in the Japanese General Population: The Ohasama Study

CKD is associated with recurrent ischemia but not with hemorrhagic transformation in acute ischemic stroke patients

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