Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure

Fotheringham, Amelia K.; Solon-Biet, Samantha M.; Bielefeldt‐Ohmann, Helle; McCarthy, Domenica A.; McMahon, Aisling C.; Ruohonen, Kari; Li, Isaac T. S.; Sullivan, Mitchell A.; Whiddett, Rani; Borg, Danielle J.; Cogger, Victoria C.; Ballard, J. William O.; Turner, Nigel; Melvin, Richard G; Raubenheimer, David; Couteur, David G. Le; Simpson, Stephen J.; Forbes, Josephine M.

doi:10.1016/j.isci.2021.103308

Cited by 6 publications

(4 citation statements)

References 125 publications

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“…Thus, the cross‐talk between rostafuroxin‐sensitive signaling pathways and RAAS deserves further studies. Moreover, the possibility of cortical lesions that aggravate hypertension in chronic needs to be considered because low‐protein intake decreases the glomerular filtration rate and leads to more significant tubular injury and inflammation (Fotheringham et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Different antihypertensive and metabolic responses to rostafuroxin in undernourished and normonourished male rats: Outcomes on bodily Na⁺ handling

Pereira‐Acácio,

Veloso‐Santos,

Alves‐Bezerra

et al. 2023

Physiological Reports

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Hypertension is a pandemic nowadays. We aimed to investigate whether chronic undernutrition modifies the response to the antihypertensive drug rostafuroxin in juvenile hypertensive rats. Chronic undernutrition was induced in male rats using a multideficient diet known as the Regional Basic Diet (RBD), mimicking alimentary habits in impoverished regions worldwide. Animals were given RBD—or a control/CTRL normal diet for rodents—from weaning to 90 days, and rostafuroxin (1 mg/kg body mass) was orally administered from day 60 onwards. For the last 2 days, the rats were hosted in metabolic cages to measure food/energy, water, Na+ ingestion, and urinary volume. Rostafuroxin increased food/energy/Na+ intake in CTRL and RBD rats but had opposite effects on Na+ balance (intake minus urinary excretion). The drug normalized the decreased plasma Na+ concentration in RBD rats, increased urinary volume in RBD but not in CTRL, and decreased and increased urinary Na+ concentration in the RBD and CTRL groups, respectively. Rostafuroxin decreased the ouabain‐sensitive (Na++K+)ATPase and increased the ouabain‐resistant Na+‐ATPase from proximal tubule cells in both groups and normalized the systolic blood pressure in RBD without effect in CTRL rats. We conclude that chronic undernutrition modifies the response of blood pressure and metabolic responses to rostafuroxin.

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Section: Discussionmentioning

confidence: 99%

Different antihypertensive and metabolic responses to rostafuroxin in undernourished and normonourished male rats: Outcomes on bodily Na⁺ handling

Pereira‐Acácio,

Veloso‐Santos,

Alves‐Bezerra

et al. 2023

Physiological Reports

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“…Питання порушень метаболічних процесів за умов надлишку сахарози або дефіциту протеїну в харчовому раціоні заслуговує на особливу увагу [1,2]. Показано, що хронічне споживання низькопротеїнового раціону може призводити до зниження маси нирок, зміни фільтраційної здатності клубочків, запалення ниркових канальців [3]. Так само надлишкове споживання сахарози сприяє прогресуванню хронічної ниркової недостатності, в основі виникнення якої лежить порушення окисновідновного балансу та внутрішньониркове запалення [4].…”

Section: вступunclassified

Activity of Poliolytic Pathway Enzymes in Rat Kidneys Under Conditions of Different Protein and Sucrose Supply in the Diet

Voloshchuk,

Kopylchuk

2024

Fiziol Zh

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The study examined the activity of enzymes in the polyol pathway and the status of free radical processes in the kidneys of rats subjected to different dietary protein and sucrose levels. It was found that the kidneys of animals consuming a highsucrose diet, irrespective of protein content, exhibited the highest increase in the activity of polyol pathway enzymes, namely aldose reductase and sorbitol dehydrogenase. Consumption of a high-sucrose diet enhances the generation of O2 •- in the kidneys by almost twofold, and hydroxyl radical by over fourfold compared to control indicators. This is accompanied by a twofold increase in the content of TBARS-active products and a threefold increase in the content of carbonyl derivatives of proteins, against the background of a decrease in the content of free thiol groups in proteins. The pronounced generation of hydroxyl radicals, accumulation of TBARS-active products, and reduction in the content of free SH-groups in proteins are characteristic of animals that consumed a high-sucrose diet in the context of dietary protein deficiency. It has been demonstrated that excessive sucrose consumption is a critical factor, influencing the activity of enzymes in the polyol pathway and the intensity of free radical processes. The obtained results may be considered as predisposing factors for disruptions in the structural and functional organization of the kidneys under conditions of nutrient imbalance.

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“…formation, fibrosis in the glomeruli and interstitial space, and tubular damage have been reported in the kidneys of protein-deficient mice. [10][11][12] The consumption of legumes with high protein contents can improve malnutrition. Most residents of developing countries consume legumes, such as soybean, peanuts, peas, and chickpeas, 13 as an alternative protein source to replace expensive animal protein and meet their protein intake needs.…”

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confidence: 99%

Bambara groundnut ameliorates kidney histology in female mice with protein deficiency

Firdiana,

Gunanegara,

Sunarti

et al. 2023

Med J Indones

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BACKGROUND Protein deficiency (PD) can lead to kidney damage. Consuming plant-based proteins may improve this condition. Bambara groundnut (Vigna subterranea)has an essential amino acid score of 80%, which is higher than other legumes; thus, it is potent in overcoming malnutrition. This study aimed to determine the effect of Bambara groundnut supplementation on kidney histology in adult female mice with PD. METHODS The study was conducted for 2 months in randomly selected female mice. These mice were grouped into the control, PD, and PD supplemented with Bambara groundnuts at 100, 200, and 300 g/kg of feed. 1 day after the last treatment, the kidneys of the mice were collected and processed histologically using the paraffin method (stained with hematoxylin and eosin and Masson’s trichrome). Parameters for observation included histopathological scoring (glomerular and interstitial space fibrosis and tubular damage), kidney histomorphometry, and organ index. Semi-quantitative data were analyzed using the Kruskal–Wallis test, while quantitative data were analyzed using one-way ANOVA (followed by Tukey’s test) and nested t-test. Statistical analysis was performed using SPSS software version 20 (IBM Corp., USA) (p≤0.05). RESULTS PD caused cell sloughing (moderate level) and dilatation (severe level) of the kidney tubules. It also reduced glomerular diameter and area by approximately 17.66% and 29%, respectively. PD and Bambara groundnut administration had no significant effects on the glomerular number, cortex and medulla thickness, distal and proximal tubule diameter, and kidney organ index (p>0.05). CONCLUSIONS Bambara groundnut (V. subterranea) administration prevented damage to the kidney’s histological structure of protein-deficient mice.

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Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure

Cited by 6 publications

References 125 publications

Different antihypertensive and metabolic responses to rostafuroxin in undernourished and normonourished male rats: Outcomes on bodily Na⁺ handling

Different antihypertensive and metabolic responses to rostafuroxin in undernourished and normonourished male rats: Outcomes on bodily Na⁺ handling

Activity of Poliolytic Pathway Enzymes in Rat Kidneys Under Conditions of Different Protein and Sucrose Supply in the Diet

Bambara groundnut ameliorates kidney histology in female mice with protein deficiency

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Kidney disease risk factors do not explain impacts of low dietary protein on kidney function and structure

Cited by 6 publications

References 125 publications

Different antihypertensive and metabolic responses to rostafuroxin in undernourished and normonourished male rats: Outcomes on bodily Na+ handling

Different antihypertensive and metabolic responses to rostafuroxin in undernourished and normonourished male rats: Outcomes on bodily Na+ handling

Activity of Poliolytic Pathway Enzymes in Rat Kidneys Under Conditions of Different Protein and Sucrose Supply in the Diet

Bambara groundnut ameliorates kidney histology in female mice with protein deficiency

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Product

Resources

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Different antihypertensive and metabolic responses to rostafuroxin in undernourished and normonourished male rats: Outcomes on bodily Na⁺ handling

Different antihypertensive and metabolic responses to rostafuroxin in undernourished and normonourished male rats: Outcomes on bodily Na⁺ handling