Kidney disease in patients with obesity: It is not always obesity-related glomerulopathy alone

Salvatore, Steven; Chevalier, James M.; Kuo, Sheng Feng; Audia, Pat; Seshan, Surya V.

doi:10.1016/j.orcp.2017.04.003

Cited by 19 publications

(18 citation statements)

References 18 publications

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“…A recent study identified obesity (defined as BMI >30 kg/ m 2 ) in 287 (4%) of all 6702 patients undergoing kidney biopsy over a 12-year period from the pathology archives of Weill Cornell Medical Center, New York, New York. 22 Among 255 biopsies with adequate tissue, 40% showed ORG alone and 60% showed another disease process. In this study it also was found that DN was the most common other disease.…”

Section: Discussionmentioning

confidence: 99%

The spectrum of kidney biopsy findings in patients with morbid obesity

Choung

Bomback

Stokes

et al. 2019

Kidney International

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Section: Discussionmentioning

confidence: 99%

The spectrum of kidney biopsy findings in patients with morbid obesity

Choung

Bomback

Stokes

et al. 2019

Kidney International

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“…ORG progresses to renal failure slower. 19,21,22 Although ORG has a better prognosis than idiopathic FSGS, it is a serious disease with long-term poor prognosis. 21,23 It is important to prevent the damage and depletion of podocytes by treatment.…”

Section: Renal Abnormalitiesmentioning

confidence: 99%

“…Creatinine levels were highest in tubulointerstitial diseases and progressive diabetic nephropathy. 22 Various renal pathologies such as diabetic nephropathy, hypertensive nephrosclerosis, mesangial cell proliferation and matrix expansion can be seen in patients with hypertension and obesity. Obesity may worsen proteinuria in non-glomerulonephritis, IgA nephropathy and benign nephrosclerosis.…”

Section: Renal Abnormalitiesmentioning

confidence: 99%

Obesity and Hypertension

Ersoy

2019

Turkish Journal of Internal Medicine

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Obesity is an important public health problem with increasing frequency, leading to different comorbidities including hypertension and can cause mortality. Possible mechanisms that increase blood pressure in overweight and obese people are renal damage, activation of the renin-angiotensin-aldosterone system, insulin resistance, hyperinsulinemia, sleep apnea syndrome, leptin-melanocortin pathway and genetic predisposition. Most of these mechanisms stimulate the sympathetic nervous system. Medical nutrition therapy, lifestyle interventions, medical and/or surgical antiobesity treatment modalities contribute to the control of blood pressure via weight loss. Besides antihypertensive medications should be chosen carefully in overweight and obese patients and drug groups preventing weight loss should not be preferred if possible.

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“…Its features include glomerulomegaly and the perihilar variant of focal segmental glomerulosclerosis (FSGS); from a clinical point of view, nephrotic proteinuria is common, while full-blown nephrotic syndrome is rare. Progression to kidney failure may occur, even in the absence of other lesions and diseases [ 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Weight Loss in Advanced Chronic Kidney Disease: Should We Consider Individualised, Qualitative, ad Libitum Diets? A Narrative Review and Case Study

Capizzi

Teta²,

Vigotti

et al. 2017

Nutrients

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In advanced chronic kidney disease, obesity may bring a survival advantage, but many transplant centres demand weight loss before wait-listing for kidney graft. The case here described regards a 71-year-old man, with obesity-related glomerulopathy; referral data were: weight 110 kg, Body Mass Index (BMI) 37 kg/m2, serum creatinine (sCr) 5 mg/dL, estimated glomerular filtration rate (eGFR) 23 mL/min, blood urea nitrogen (BUN) 75 mg/dL, proteinuria 2.3 g/day. A moderately restricted, low-protein diet allowed reduction in BUN (45–55 mg/dL) and good metabolic and kidney function stability, with a weight increase of 6 kg. Therefore, he asked to be enrolled in a weight-loss program to be wait-listed (the two nearest transplant centres required a BMI below 30 or 35 kg/m2). Since previous low-calorie diets were not successful and he was against a surgical approach, we chose a qualitative, ad libitum coach-assisted diet, freely available in our unit. In the first phase, the diet is dissociated; he lost 16 kg in 2 months, without need for dialysis. In the second maintenance phase, in which foods are progressively combined, he lost 4 kg in 5 months, allowing wait-listing. Dialysis started one year later, and was followed by weight gain of about 5 kg. He resumed the maintenance diet, and his current body weight, 35 months after the start of the diet, is 94 kg, with a BMI of 31.7 kg/m2, without clinical or biochemical signs of malnutrition. This case suggests that our patients can benefit from the same options available to non-CKD (chronic kidney disease) individuals, provided that strict multidisciplinary surveillance is assured.

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Kidney disease in patients with obesity: It is not always obesity-related glomerulopathy alone

Cited by 19 publications

References 18 publications

The spectrum of kidney biopsy findings in patients with morbid obesity

The spectrum of kidney biopsy findings in patients with morbid obesity

Obesity and Hypertension

Weight Loss in Advanced Chronic Kidney Disease: Should We Consider Individualised, Qualitative, ad Libitum Diets? A Narrative Review and Case Study

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