Kidney cancer mortality disparities among Hispanics in the US

Pinheiro, Paulo Sérgio; Medina, Heidy N.; Callahan, Karen E.; Koru‐Sengul, Tulay; Sharma, Janaki; Kobetz, Erin; Penedo, Frank J.

doi:10.1016/j.canep.2021.101938

Cited by 13 publications

(18 citation statements)

References 37 publications

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“…We previously reported inconsistent findings for mortality between NCDB and Arizona Cancer Registry data in HAs [ 39 ]. Arizona Cancer Registry data showed an increased risk of mortality in Mexican Americans, which is consistent with other studies [ 2 , 43 ], but lack of association for Mexican Americans and reduced risk for HA as a group in NCDB. Regional differences or incomplete follow-up in the administrative data may have contributed to this difference, and further investigation is necessary for HAs [ 44 ].…”

Section: Discussionsupporting

confidence: 91%

“…Unlike this study in a single-payer healthcare system, our sub-analysis focusing on HA subgroups showed that Mexicans/Chicanos had higher odds of undergoing radical nephrectomy and South or Central Americans had lower odds of undergoing radical nephrectomy. Higher kidney cancer mortality rates in Mexicans when compared to non-Mexican Hispanic groups or NHWs have been reported [ 2 , 39 ]. However, in NCDB, HAs tend to have a lower risk of overall mortality.…”

Section: Discussionmentioning

confidence: 99%

“…Racial/ethnic minority groups in the United States (U.S.) have a disproportionate kidney cancer burden with high incidence and mortality rates [ 1 , 2 , 3 ]. Many small renal masses, as well as early-stage kidney cancer, can be resected through partial nephrectomy, a less invasive surgical treatment than radical nephrectomy [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Impacts of Neighborhood Characteristics and Surgical Treatment Disparities on Overall Mortality in Stage I Renal Cell Carcinoma Patients

Cruz

Dickerson

Pulling

et al. 2022

IJERPH

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Racial/ethnic minority groups in the United States have high renal cell carcinoma (RCC) mortality rates. This study assessed surgical treatment disparities across racial/ethnic groups and impacts of neighborhood socioeconomic characteristics on surgical treatments and overall mortality. Stage I RCC patients diagnosed between 2004 and 2016 from National Cancer Database were included (n = 238,141). We assessed differences in associations between race/ethnicity and treatment patterns using logistic regression and between race/ethnicity and overall mortality using Cox regression with and without neighborhood characteristics in the regression models. When compared to non-Hispanic Whites (NHWs), American Indians/Alaska Natives and non-Hispanic Blacks (NHBs) were more likely not to receive surgical care and all racial/ethnic minority groups had significantly increased odds of undergoing radical rather than partial nephrectomy, even after adjusting for neighborhood characteristics. Including surgical treatment and neighborhood factors in the models slightly attenuated the association, but NHBs had a significantly increased risk of overall mortality. NHBs who underwent radical nephrectomy had an increased risk of mortality (HR 1.15, 95% CI: 1.08–1.23), but not for NHBs who underwent partial nephrectomy (HR 0.92, 95% CI: 0.84–1.02). Neighborhood factors were associated with surgical treatment patterns and overall mortality in both NHBs and NHWs. Neighborhood socioeconomic factors may only partly explain RCC disparities.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Impacts of Neighborhood Characteristics and Surgical Treatment Disparities on Overall Mortality in Stage I Renal Cell Carcinoma Patients

Cruz

Dickerson

Pulling

et al. 2022

IJERPH

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“…Information on recurrence and mortality was not collected as a part of this study, and we were not able to evaluate the long-term effects of prolonged SWT. However, this study is unique and has a high representation of racial/ethnic minority groups, such as HAs and AIs/ANs with high RCC mortality, that have been previously underrepresented in RCC studies [ 5 , 8 , 39 ]. In our state, a large part of the state is categorized as medically underserved, including areas with high proportions of racial/ethnic minority residents.…”

Section: Discussionmentioning

confidence: 99%

Racial and Ethnic Disparities in Preoperative Surgical Wait Time and Renal Cell Carcinoma Tumor Characteristics

et al. 2021

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Racial/ethnic minority groups have a disproportionate burden of kidney cancer. The objective of this study was to assess if race/ethnicity was associated with a longer surgical wait time (SWT) and upstaging in the pre-COVID-19 pandemic time with a special focus on Hispanic Americans (HAs) and American Indian/Alaska Natives (AIs/ANs). Medical records of renal cell carcinoma (RCC) patients who underwent nephrectomy between 2010 and 2020 were retrospectively reviewed (n = 489). Patients with a prior cancer diagnosis were excluded. SWT was defined as the date of diagnostic imaging examination to date of nephrectomy. Out of a total of 363 patients included, 34.2% were HAs and 8.3% were AIs/ANs. While 49.2% of HA patients experienced a longer SWT (≥90 days), 36.1% of Non-Hispanic White (NHW) patients experienced a longer SWT. Longer SWT had no statistically significant impact on tumor characteristics. Patients with public insurance coverage had increased odds of longer SWT (OR 2.89, 95% CI: 1.53–5.45). Public insurance coverage represented 66.1% HA and 70.0% AIs/ANs compared to 56.7% in NHWs. Compared to NHWs, HAs had higher odds for longer SWT in patients with early-stage RCC (OR, 2.38; 95% CI: 1.25–4.53). HAs (OR 2.24, 95% CI: 1.07–4.66) and AIs/ANs (OR 3.79, 95% CI: 1.32–10.88) had greater odds of upstaging compared to NHWs. While a delay in surgical care for early-stage RCC is safe in a general population, it may negatively impact high-risk populations, such as HAs who have a prolonged SWT or choose active surveillance.

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“…Across the United States (U.S.), American Indians/Alaska Natives (AI/AN) and Hispanic Americans (HA) have higher kidney cancer incidence and mortality rates compared to non-Hispanic Whites (NHW) [1][2][3]. Additionally, in Arizona, AI/AN and HA experience a significantly higher incidence of kidney cancer compared to NHW, with AI/AN men having kidney cancer as the second most commonly diagnosed cancer with a 1.9-fold higher incidence [4].…”

Section: Introductionmentioning

confidence: 99%

Renal Cell Carcinoma Surgical Treatment Disparities in American Indian/Alaska Natives and Hispanic Americans in Arizona

Gachupin

Lee

Chipollini

et al. 2022

IJERPH

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American Indians/Alaska Natives (AI/AN) and Hispanic Americans (HA) have higher kidney cancer incidence and mortality rates compared to non-Hispanic Whites (NHW). Herein, we describe the disparity in renal cell carcinoma (RCC) surgical treatment for AI/AN and HA and the potential association with mortality in Arizona. A total of 5111 stage I RCC cases diagnosed between 2007 and 2016 from the Arizona Cancer Registry were included. Statistical analyses were performed to test the association of race/ethnicity with surgical treatment pattern and overall mortality, adjusting for patients’ demographic, healthcare access, and socioeconomic factors. AI/AN were diagnosed 6 years younger than NHW and were more likely to receive radical rather than partial nephrectomy (OR 1.49 95% CI: 1.07–2.07) compared to NHW. Mexican Americans had increased odds of not undergoing surgical treatment (OR 1.66, 95% CI: 1.08–2.53). Analysis showed that not undergoing surgical treatment and undergoing radical nephrectomy were statistically significantly associated with higher overall mortality (HR 1.82 95% CI: 1.21–2.76 and HR 1.59 95% CI: 1.30–1.95 respectively). Mexican Americans, particularly U.S.-born Mexican Americans, had an increased risk for overall mortality and RCC-specific mortality even after adjusting for neighborhood socioeconomic factors and surgical treatment patterns. Although statistically not significant after adjusting for neighborhood-level socioeconomic factors and surgical treatment patterns, AI/AN had an elevated risk of mortality.

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Kidney cancer mortality disparities among Hispanics in the US

Cited by 13 publications

References 37 publications

Impacts of Neighborhood Characteristics and Surgical Treatment Disparities on Overall Mortality in Stage I Renal Cell Carcinoma Patients

Impacts of Neighborhood Characteristics and Surgical Treatment Disparities on Overall Mortality in Stage I Renal Cell Carcinoma Patients

Racial and Ethnic Disparities in Preoperative Surgical Wait Time and Renal Cell Carcinoma Tumor Characteristics

Renal Cell Carcinoma Surgical Treatment Disparities in American Indian/Alaska Natives and Hispanic Americans in Arizona

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