Kidney adaptation in nitric oxide-deficient Wistar and spontaneously hypertensive rats

Pereira, Leila Maria Meirelles; Almeida, Jorge Reis; Mandarim-de-Lacerda, Carlos Alberto

doi:10.1016/j.lfs.2003.08.015

Cited by 7 publications

(2 citation statements)

References 46 publications

(47 reference statements)

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“…Changes in glomerular and vascular densities were also observed in this model using stereological analysis 41. The BPs achieved in the animals used in these previous studies were 212 and 200–225 mmHg, respectively.…”

Section: Discussionmentioning

confidence: 52%

Rosuvastatin prevents proteinuria and renal inflammation in nitric oxide–deficient rats

Girardi

Farias

Ferreira

et al. 2011

Clinics

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OBJECTIVE:The aim of the present study was to assess the effects of rosuvastatin on renal injury and inflammation in a model of nitric oxide deficiency.METHODS:Male Wistar rats were randomly divided into four groups (n = 10/group) and treated for 28 days with saline (CTRL); 30 mg/kg/day L-NAME (L-name); L-NAME and 20 mg/kg/day rosuvastatin (L-name+ROS-20); or L-NAME and 2 mg/kg/day rosuvastatin (L-name+ROS-2). Systolic blood pressure was measured by plethysmography in the central artery of the tail. The serum total cholesterol, triglycerides, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, creatinine, nitric oxide, interleukin-6, and tumor necrosis factor alpha levels were analyzed. Urine samples were taken to measure the albumin∶urinary creatinine ratio. Kidneys were sectioned and stained with hematoxylin/eosin and Masson's trichrome. Immunohistochemical analysis of the renal tissue was performed to detect macrophage infiltration of the glomeruli.RESULTS:The systolic blood pressure was elevated in the L-name but not the L-name+rosuvastatin-20 and L-name+rosuvastatin-2 groups. The L-name group had a significantly reduced nitric oxide level and an increased interleukin-6 and tumor necrosis factor alpha level, albumin∶urinary creatinine ratio and number of macrophages in the renal glomeruli. Rosuvastatin increased the nitric oxide level in the L-name+rosuvastatin-2 group and reduced the interleukin-6 and tumor necrosis factor alpha levels, glomerular macrophage number and albumin∶urinary creatinine ratio in the L-name+rosuvastatin-20 and L-name+rosuvastatin-2 groups.CONCLUSION:Rosuvastatin treatment reduced glomerular damage due to improvement in the inflammatory pattern independent of the systolic blood pressure and serum lipid level. These effects may lead to improvements in the treatment of kidney disease.

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Section: Discussionmentioning

confidence: 52%

Rosuvastatin prevents proteinuria and renal inflammation in nitric oxide–deficient rats

Girardi

Farias

Ferreira

et al. 2011

Clinics

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“…L-NAME is one of l-arginine analogues, by binding competitively to NO synthase (NOS), was shown to attenuate both production and metabolic pathway of NO and to cause tissue injuries (Sanada et al, 2003) characterized by cardiac remodeling (Bernàtovà et al, 2002;Opie et al, 2006), an impairment of endothelial dependent relaxation (Katoh et al, 2000;Vardi et al, 2003), renal function alteration and a decrease in baroreflex responsiveness (Lantelme et al, 1994;Scrogin et al, 1998;Souza et al, 2001;Peotta et al, 2001). Several studies have shown that the antihypertensive treatment with angiotensinconverting enzyme inhibitors (ACEI) such as enalapril, captopril and perindopril (Pechanova and Bernatova, 2000;Vapaatalo et al, 2000;Schiffrin, 2001;De Gennaro Colonna et al, 2002;Pereira et al, 2003Pereira et al, , 2004Khattab et al, 2005) would be able to regress or counterbalance these changes and prevent the development of hypertension. The same result was observed by the use of l-arginine, the precursor of NO synthesis that can increase endothelium activity (Katoh et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Arbutus unedo prevents cardiovascular and morphological alterations in L-NAME-induced hypertensive rats

Afkir

Nguelefack

Aziz

et al. 2008

Journal of Ethnopharmacology

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Chlorella pyrenoidosa ameliorated L-NAME-induced hypertension and cardiorenal remodeling in rats

Yang

et al. 2012

Eur J Nutr

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Kidney adaptation in nitric oxide-deficient Wistar and spontaneously hypertensive rats

Cited by 7 publications

References 46 publications

Rosuvastatin prevents proteinuria and renal inflammation in nitric oxide–deficient rats

Rosuvastatin prevents proteinuria and renal inflammation in nitric oxide–deficient rats

Arbutus unedo prevents cardiovascular and morphological alterations in L-NAME-induced hypertensive rats

Chlorella pyrenoidosa ameliorated L-NAME-induced hypertension and cardiorenal remodeling in rats

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