Kibra Modulates Learning and Memory via Binding to Dendrin

Ji, Zeyang; Li, Hao; Zhou, Yang; Huang, Xiji; Ke, Xiao; Ma, Sehui; Lin, Zhijie; Lu, Youming; Zhang, Mingjie

doi:10.1016/j.celrep.2019.01.097

Cited by 37 publications

(90 citation statements)

References 47 publications

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“…Notably, the extensive interactions between the inter-domain linker and the C-terminal helix stabilize the supramodular structure of the MAGI2 WW tandem, and the Dendrin PY23 binds to the MAGI2 WW tandem following almost the exactly same detailed interactions as those observed in the KIBRA WW12/Dendrin PY23 complex ( Fig. 3E) (Ji et al, 2019).…”

Section: The Ww Tandems Of Magi2/3 and Kibra Resemble With Each Othermentioning

confidence: 73%

“…We have also demonstrated that bindings of short PY motif containing peptides to WW tandems can be readily enhanced to sub-nanomolar affinities (Fig. 6B), and these super-strong WW tandem binding peptides may be used as effective tools for studying the role of specific interactions between WW tandem proteins and target proteins (see (Ji et al, 2019) for an example). As for the very weak WW domain/target interactions, cautions are required in interpreting potential functional implications of such bindings.…”

Section: Discussionmentioning

confidence: 87%

“…Presumably, those highly affinity WW tandem-mediated target interactions should play specific functions. For example, we recently showed that the tight binding between KIBRA and Dendrin (Kd ~2.1 nM) is critical for KIBRA (and its associated AMPA receptors) localization in neuronal synapses and for synaptic plasticity (Ji et al, 2019). We have also demonstrated that bindings of short PY motif containing peptides to WW tandems can be readily enhanced to sub-nanomolar affinities (Fig.…”

Section: Discussionmentioning

confidence: 95%

“…single point mutations such as I35D, F47A, L57D, and W88A, or deletion of the α2 helix) invariably weakened the binding of the WW tandem to its targets ( Fig. 3B), indicating that formation of the WW12 supramodule is critical for high affinity bindings to the three targets studied here as well as to PY23 of Dendrin (Ji et al, 2019).…”

Section: Structures Of the Kibra Ww Tandem In Complex With Py-motifsmentioning

confidence: 87%

“…We also included another PY-motif containing protein Dendrin in the study, serving as a reference for super strong binding involving WW domains (Kd ~2.1 nM, Fig. 1D; also see our recent work by (Ji et al, 2019)). Similar to the two PY-motifs of Dendrin that are separated by only two residues, the first two PY-motifs of PTPN14 are also next to each other with only two residues in between, and the PY12 motif sequence is evolutionarily conserved (Fig.…”

Section: Ww Tandem-mediated Bindings To Py-motif Proteins Can Be Extrmentioning

confidence: 99%

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Decoding WW Domain Tandem-mediated Target Recognitions in Tissue Growth and Cell Polarity

Lin

Zhou

Xie

et al. 2019

Preprint

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WW domain tandem-containing proteins such as KIBRA, YAP, and MAGI play critical roles in cell growth and polarity via binding to and positioning target proteins in specific subcellular regions. An immense disparity exists between promiscuity of WW domain-mediated target bindings and specific roles of WW domain scaffold proteins in cell growth regulation. Here, we discovered that WW domain tandems of KIBRA and MAGI, but not YAP, bind to specific target proteins with extremely high affinity and exquisite specificity. Via systematic structural biology and biochemistry approaches, we decoded the target binding rules of WW domain tandems from cell growth regulatory proteins and uncovered a list of previously unknown WW tandem binding proteins such as β-Dystroglycan, JCAD, and PTPN21. The WW tandemmediated target recognition mechanisms elucidated here can guide functional studies of WW domain proteins in cell growth and polarity as well as in other cellular processes including neuronal synaptic signaling.

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Section: The Ww Tandems Of Magi2/3 and Kibra Resemble With Each Othermentioning

confidence: 73%

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 95%

Section: Structures Of the Kibra Ww Tandem In Complex With Py-motifsmentioning

confidence: 87%

Section: Ww Tandem-mediated Bindings To Py-motif Proteins Can Be Extrmentioning

confidence: 99%

See 3 more Smart Citations

Decoding WW Domain Tandem-mediated Target Recognitions in Tissue Growth and Cell Polarity

Lin

Zhou

Xie

et al. 2019

Preprint

Self Cite

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Brain microstructural alterations in the left precuneus mediate the association between KIBRA polymorphism and working memory in healthy adults: a diffusion kurtosis imaging study

Wang

Sun

et al. 2022

Brain Imaging and Behavior

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Kidney and brain expressed protein (KIBRA) rs17070145 is associated with working memory function and cognitive processes. However, the neural mechanisms underlying these associations are not fully understood. This study aimed to explore the effect of KIBRA polymorphism on brain microstructure and blood oxygenation level dependent (BOLD) fluctuations using diffusion kurtosis imaging (DKI) and resting-state functional magnetic resonance imaging (fMRI) in 163 young adults. We also investigated that whether the imaging alterations mediated the association between KIBRA gene and working memory performance. Voxel-based analysis of DKI data showed that KIBRA C-allele carriers exhibited increased axial diffusivity (AD), radial diffusivity (RD) and mean diffusivity (MD) as well as decreased fractional anisotropy (FA), mean kurtosis (MK) and radial kurtosis (RK) compared with KIBRA TT homozygotes, primarily involving the prefrontal lobe, left precuneus and the left superior parietal white matter. Meanwhile, KIBRA C-allele carriers exhibited decreased amplitude of low-frequency fluctuation (ALFF) in the left precuneus compared to KIBRA TT homozygotes. Mediation analysis revealed that the DKI metrics (MK and RK) of the left precuneus mediated the effect of the KIBRA polymorphism on working memory performance. Moreover, the MK and RK in the left precuneus were positively correlated with ALFF in the same brain region. These findings suggest that abnormal DKI parameters may provide a gene-brain-behavior pathway in which KIBRA rs17070145 affects working memory by modulating brain microstructure in the left precuneus. This illustrates that DKI may provide additional biological information and reveal new insights into the neural mechanisms of the KIBRA polymorphism.

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SNX17 Mediates Dendritic Spine Maturation via p140Cap

Cui,

Liang,

et al. 2023

Mol Neurobiol

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Kibra Modulates Learning and Memory via Binding to Dendrin

Cited by 37 publications

References 47 publications

Decoding WW Domain Tandem-mediated Target Recognitions in Tissue Growth and Cell Polarity

Decoding WW Domain Tandem-mediated Target Recognitions in Tissue Growth and Cell Polarity

Brain microstructural alterations in the left precuneus mediate the association between KIBRA polymorphism and working memory in healthy adults: a diffusion kurtosis imaging study

SNX17 Mediates Dendritic Spine Maturation via p140Cap

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