KIBRA Co-Localizes with Protein Kinase Mζ (PKMζ) in the Mouse Hippocampus

Yoshihama, Yohei; Hirai, Takanori; Ohtsuka, Takashi; Chida, Kazuhiro

doi:10.1271/bbb.80564

Cited by 36 publications

(44 citation statements)

References 31 publications

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“…The KIBRA protein has been linked to memory-related processes through interaction with several postsynaptic proteins involved in synaptic plasticity and induction of long-term potentiation, including dendrin, synaptopodin, and PKC molecules (Büther et al, 2004;Schneider et al, 2010). Yoshihama et al (2009) recently showed, in the mouse hippocampus, that KIBRA colocalizes with PKM, the only known molecule both necessary and sufficient for long-term potentiation maintenance (Sacktor, 2008), and this interaction was suggested as the functional role of KIBRA in memory.…”

Section: Discussionmentioning

confidence: 99%

KIBRA Polymorphism Is Related to Enhanced Memory and Elevated Hippocampal Processing

Kauppi

Nilsson²,

Adolfsson³

et al. 2011

J. Neurosci.

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Several studies have linked the KIBRA rs17070145 T polymorphism to superior episodic memory in healthy humans. One study investigated the effect of KIBRA on brain activation patterns (Papassotiropoulos et al., 2006) and observed increased hippocampal activation in noncarriers of the T allele during retrieval. Noncarriers were interpreted to need more hippocampal activation to reach the same performance level as T carriers. Using large behavioral (N ϭ 2230) and fMRI (N ϭ 83) samples, we replicated the KIBRA effect on episodic memory performance, but found increased hippocampal activation in T carriers during episodic retrieval. There was no evidence of compensatory brain activation in noncarriers within the hippocampal region. In the main fMRI sample, T carriers performed better than noncarriers during scanning but, importantly, the difference in hippocampus activation remained after post hoc matching according to performance, sex, and age (N ϭ 64). These findings link enhanced memory performance in KIBRA T allele carriers to elevated hippocampal functioning, rather than to neural compensation in noncarriers.

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Section: Discussionmentioning

confidence: 99%

KIBRA Polymorphism Is Related to Enhanced Memory and Elevated Hippocampal Processing

Kauppi

Nilsson²,

Adolfsson³

et al. 2011

J. Neurosci.

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show abstract

“…KIBRA RNA is expressed in the whole brain with a peak in memory-related structures such as the hippocampus and the temporal lobe (Papassotiropoulos et al, 2006). As a component of the neuronal cytoskeleton, KIBRA might have a role in brain development connecting cytoskeletal and signaling molecules (Johannsen et al, 2008;Yoshihama et al, 2009). KIBRA is also a substrate for protein kinase Cz, which is crucially involved in synaptic plasticity and memory formation (Buther et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…The KIBRA protein is discussed to be involved in brain development and memory formation as a postsynaptic scaffold protein connecting cytoskeletal and signaling molecules (Johannsen et al, 2008;Yoshihama et al, 2009). However, results for episodic memory have been inconsistent across studies, ranging from the originally reported beneficial effects of the T-allele on memory functions (Almeida et al, 2008;Papassotiropoulos et al, 2006;Schaper et al, 2008;Yasuda et al, 2010;Vassos et al, 2010) to null findings (Need et al, 2008) and to even poorer memory in T-allele carriers (Nacmias et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Impact of Common KIBRA Allele on Human Cognitive Functions

Wersching

Guske

Hasenkamp

et al. 2011

Neuropsychopharmacol

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The rs17070145 polymorphism (C-T substitution, intron 9) of the KIBRA gene has recently been associated with episodic memory and cognitive flexibility. These findings were inconsistent across reports though, and largely lacked gene-gene or gene-environment interactions. The aim of the present study was to determine the impact of the rs17070145 polymorphism on clinically relevant cognitive domains and its interaction with the modifiers 'lifestyle' and 'cardiovascular risk factors'. Five-hundred forty-five elderly volunteers (mean age 64 years, ± 7 years, 56% women) accomplished a comprehensive cognitive testing. Principal component analysis was used to reveal the internal structure of the data, rendering four composite scores: verbal memory, word fluency, executive function/psychomotor speed, and working memory. Lifestyle was assessed with a detailed questionnaire, age-associated risk factors by clinical interview and examination. There was no main effect of the rs17070145 genotype on any cognitive composite scores. However, we found worse performance in executive functions for T-allele carriers in the presence of arterial hypertension (b ¼ À0.365, p ¼ 0.0077 and 0.031 after Bonferroni correction). This association was further modified by gender, showing the strongest association in hypertensive females (b ¼ À0.500, p ¼ 0.0072 and 0.029 after Bonferroni correction). The effect of KIBRA on cognitive function seems to be complex and modified by gender and arterial hypertension.

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“…It interacts with dynein light chain 1 to activate the oestrogen receptor (Rayala et al 2006) and discoidin domain receptor 1 to modulate collagen-induced signalling (Hilton et al 2008). Recently, protein kinase Mζ, a brain-specifi c variant of PKCζ, was reported to be combined with KIBRA and supposed to modulate molecular pathways of memory formation (Yoshihama et al 2009). …”

Section: Cognitive Testsmentioning

confidence: 99%