Ki-67, p53 and epidermal growth factor receptor expression in early glottic cancer involving the anterior commissure treated with radiotherapy

Ahmed, Wael A.; Suzuki, Kenji; Imaeda, Yoshihiro; Horibe, Yoshimune

doi:10.1016/j.anl.2007.08.011

Cited by 16 publications

(19 citation statements)

References 32 publications

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“…Many recent studies have suggested novel markers of radiosensitivity, such as DNA ploidy [21], expression of epidermal growth factor [22], p53 [22,23], Bcl-2 [24], and microvessel density [25]. Regarding microvessel density, the biological effects of ionizing radiation are critically dependent on the existence of oxygen in tissues, which may be another reason for the poor responses.…”

Section: Discussionmentioning

confidence: 99%

Radiotherapy with or without chemotherapy for patients with T1-T2 glottic carcinoma: retrospective analysis

et al. 2010

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BackgroundTo assess the results for local control (LC) and survival in patients with early-stage glottic cancer (GC) who were treated by radiotherapy (RT) with or without chemotherapy.MethodsFifty-eight patients with T1-T2 squamous cell carcinoma of the glottis who were treated between 2001 and 2006 were analyzed retrospectively. Potential prognostic factors for LC were evaluated by univariate analysis.ResultsThe 5-year LC rate in all patients was 84.3%. The overall 5-year LC rates for patients with T1a, Tb, and T2 GC were 85.9%, 83%, and 85%, respectively. Of the 58 patients, eight developed recurrent disease at the primary site, and one had lymph node recurrences on the neck. In the final analysis, the total laryngectomy-free survival rate was 93% at five years, and the ultimate LC rates for T1a, Tb, and T2 were 100%, 90.9%, and 95.2%, respectively. In a univariate analysis of 55 patients, there was no statistical significance between the LC rate for RT alone and that for chemoradiation. Only two patients died of laryngeal carcinoma, and one died of intercurrent disease. Fifty-five patients were living disease-free at the end of the study period. The 5-year overall survival (OS) rate for all patients was 88.1%, and the 5-year OS rates for T1a, Tb, and T2 were 91.6%, 77.8%, and 89.9%, respectively.ConclusionsThe retrospective analysis showed a high rate of LC and larynx preservation in patients with T1-T2 GC by means of RT with or without chemotherapy. There was, however, no statistical difference in LC rates for the two types of therapy.

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Section: Discussionmentioning

confidence: 99%

Radiotherapy with or without chemotherapy for patients with T1-T2 glottic carcinoma: retrospective analysis

et al. 2010

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“…Some human cancers have been shown to have higher Ki-67 tumors and were linked to better outcomes with radiation therapy [ 2 , 7 , 10 , 18 ]. A study on feline squamous cell carcinoma also found that cats with higher Ki-67 had markedly favorable prognosis than cats with lower Ki-67 [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…Ki-67 is a non-histone nuclear protein that is expressed in actively proliferating cells during all phases of cell cycle, except G0, resting phase. In previous studies, high Ki-67-positive tumors responded better to radiation therapy than tumors with lower level of Ki-67 in several human cancers [ 2 , 7 , 10 , 18 ]. Therefore, a high Ki-67-positive tumor is believed to be associated with radiosensitivity, because it is likely to be radioresistant in the G0 phase.…”

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confidence: 99%

Apoptosis and Ki-67 as predictive factors for response to radiation therapy in feline nasal lymphomas

Kato

Endo

et al. 2016

The Journal of Veterinary Medical Science

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Nasal lymphoma is the most common nasal tumor in cats and is generally a solitary and radiosensitive tumor. We retrospectively evaluated the response to radiation and survival time in relation to apoptosis and Ki-67 indices in feline nasal lymphomas treated with radiation therapy. The apoptotic and Ki-67 indices were evaluated with TUNEL and immunohistochemical staining in 30 biopsy tissues that were taken before any treatment. These two indices were compared, and differences between different treatment response groups were analyzed. The correlation between the median survival times (MST) and the indices was estimated using the Kaplan Meier method, and statistical differences between survival curves were analyzed using a log-rank method. With regard to apoptotic index, a statistical difference was observed between the samples taken from cats with complete response and stable disease (1.22% vs. 0.45%; P=0.045). The Ki-67 index in cats with both complete response and partial response was significantly higher than in cats with stable disease (44.4% and 39.6% vs. 16.3%; P<0.001 and P=0.008, respectively). The cats with a high level of apoptosis (>0.9%) nasal lymphoma were not significantly prolonged MSTs (P=0.202), however, high Ki-67-positive (>40%) cats experienced a statistically significant relationship with longer survival time (P=0.015). Our results indicate that spontaneous apoptotic and Ki-67 indices are strong predictors for response to radiation therapy in feline nasal lymphomas.

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“…In contrast, in hundreds of studies p53 immunohistochemistry was reported using different kinds of antibodies, procedures, and scoring criteria. For this study, we focused on those studies using immunostaining of p53 in relation with response to radiotherapy in LSCC and found clone DO‐07 was used in most studies For all three antibodies we assessed immunoreactivity only in the nucleus of neoplastic cells and nuclear staining above the level of any cytoplasmic background was considered as positive staining. The percentages of positively stained neoplastic cells in total neoplastic area were scored by two separated teams.…”

Section: Methodsmentioning

confidence: 99%

High pATM is Associated With Poor Local Control in Supraglottic Cancer Treated With Radiotherapy

et al. 2020

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Objectives Most early stage laryngeal squamous cell carcinomas (LSCC) are treated with radiotherapy. Discovery of new biomarkers are needed to improve prediction of outcome after radiotherapy and to identify potential targets for systemic targeted therapy. The ataxia telangiectasia mutated (ATM) gene plays a critical role in DNA damage response induced by ionizing radiation. Methods The prognostic value of immunohistochemical expression of pATM, pChk2, and p53 were investigated in 141 patients with T1‐T2 LSCC curatively treated with external beam radiotherapy. Uni‐ and multivariable Cox regression analyses were performed to examine the relation between expression levels of markers and local control. Results Local control was significantly worse in cases with high levels of pATM (HR 2.14; 95% CI, 1.08–4.24; P = .03). No significant associations with local control were found for pChk2 and p53 expression. The association of high pATM expression with poor local control was only found for supraglottic LSCC (HR 10.9; 95% CI, 1.40–84.4; P = .02). Conclusion Our findings suggest a potential role for ATM in response to radiotherapy in early stage supraglottic LSCC and imply ATM inhibition as a possibility to improve response to radiotherapy. Level of Evidence NA Laryngoscope, 130: 1954–1960, 2020

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Ki-67, p53 and epidermal growth factor receptor expression in early glottic cancer involving the anterior commissure treated with radiotherapy

Cited by 16 publications

References 32 publications

Radiotherapy with or without chemotherapy for patients with T1-T2 glottic carcinoma: retrospective analysis

Radiotherapy with or without chemotherapy for patients with T1-T2 glottic carcinoma: retrospective analysis

Apoptosis and Ki-67 as predictive factors for response to radiation therapy in feline nasal lymphomas

High pATM is Associated With Poor Local Control in Supraglottic Cancer Treated With Radiotherapy

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