Ki-67 Expression in Endometrial Hyperplasia

Shalini, P; Suresh, Natrajan; Ganapathy, Hemalatha

doi:10.5958/0976-5506.2019.04232.3

Cited by 2 publications

(9 citation statements)

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“…On the contrary, this work concluded that the highest mean of percentage of Ki67 expression was in sections of proliferative endometrium. These findings are similar to those of other studies which revealed that similar pattern of high proliferative activity in glandular epithelium in cases of proliferative endometrium 29,38 . The expression of Ki67 normally enhanced throughout the proliferative phase of the menstrual cycle, 11 .…”

Section: Discussionsupporting

confidence: 92%

“…This work showed variable expressions of Ki67 among spectrum of endometrial lesions. These findings are similar to those of Adomaitiene et al, 2019 11 , and those of Shalini et al, 2019 29 . Analysis of immunohistochemical expression of Ki67 in sections of women presented with AUB revealed that there is a relation with the age of patients.…”

Section: Discussionsupporting

confidence: 92%

“…There a potential correlation between breast malignant tumor's aggressiveness and the neoplastic cells' proliferation, and this identified via immunohistochemical detection of proliferative index (Ki67). American Society of Clinical Oncology (ASCO) has not recommend utility of Ki-67 as a routine for prediction of the endometrial cancer's outcomes Among the proteins that in general is associated with proliferation and growth of tumor cells is a nuclear protein-Ki67, so it is considered as an excellent marker as the cancer cells are characterized by their higher proliferation rate 29,38 . Physically, the quantification of Ki67 is a direct measurement of the proliferative activity of a cell.…”

Section: Discussionmentioning

confidence: 99%

“…Immunohistochemical stains is an effective method to assess the proportion of tumor cells. Nowadays, various techniques are present to count Ki67 in different forms of cancer 23,29 . The most widely measurement of the proliferation status of tumors via Ki67 as a good clinical marker for decisions for treatment 11 .…”

Section: Discussionmentioning

confidence: 99%

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Clarification of Ki67 Expression in Association with the Histological Picture of Endometrium in Cases with Abnormal Uterine Bleeding in Nineveh Province

Alnuaimy¹,

Al-Allaf²,

Al-Omar³

2021

Ann Coll Med Mosul

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Background: Among the frequent daily challenges in the practice of gynecology are abnormal uterine bleeding (AUB) beside the distinction of fundamental endometrial lesions that stand behind it .Ki67 is among the excellent markers as the higher proliferation rate is one of the features of cancer cells. Aim: This study aims to clarify the expression of Ki67 in the endometrium of women suffering from abnormal uterine bleeding in Nineveh Province and to correlate its expression with the histological picture. Subjects, Materials, and Methods: This is a case series study that was enrolled analysis of data (retrospectively and prospectively) of 51 females who were presented with history of abnormal uterine bleeding and they were underwent an elective D&C and or hysterectomy after admission in several Hospitals, in Nineveh Province, Northern Iraq from 1 st January, 2020 to 30 th December, 2020. The selected paraffin blocks (n-=51) were cut into 3-4 micrometers thick sections and mounted on poly-L-lysine glass slides for immunohistochemical staining with using of positive and negative control sections at Unit of Immunohistochemistry in Vin Hospital -Duhok-North of Iraq. Staining was performe using the optimized protocol recommended by the International Ki67 in Breast Cancer Working Group together with Dako Autostainer according to manufacturer instructions. Results: This work revealed that 23(45%) out of 51 cases were aged >50 years. The highest mean of percentage of Ki67expression was in sections of proliferative endometrium. In fact, sections of 3/7 of cases which were exhibited a percentage of Ki67 expression from 76% to 100% aged >50 years, while sections of 3/7 of cases of menopause women showed percentage of Ki67 expression from 26% to 75 %. Further, 12 cases out of 17 showed an intensity of staining score of 2 were aged ˂50 years, while 3 out of 5 cases (which revealed an intensity of 3 ) were aged < 50 years. Five cases out of 17 which showed an intensity of staining score of 2 were aged >50 years, while 2 out of 5 cases which exhibited an intensity score of 3 were aged > 50 years. The current study showed that 11/16 cases of benign conditions presented with percentage of Ki67 expression of less than 25%,while 14/15 cases of endometrial hyperplasia presented with Ki67 expression of <25%. In contrary, 8 cases out of 20 of cases of endometrial adenocarcinoma showed Ki67 expression of >25%. Further, the intensity of Ki67 immunostaining of more than 2 was shown in 4 cases of endometrial adenocarcinoma. Regarding cases of endometrial hyperplasia, the current work revealed that 7 cases (46%) out of 15 cases were aged more than 50 years. About 4 cases (26%) of them are of atypical type with no significant differences between the percentage and intensity of Ki67 expression in cases of endometrial hyperplasia. In fact, 15 cases (75%) of endometrial adenocarcinoma were aged more than 50 years. Four (20%) of them were of grade 3, while six cases (30%) of them were of grade 2. According to the grade of endometrial adenocarcin...

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Clarification of Ki67 Expression in Association with the Histological Picture of Endometrium in Cases with Abnormal Uterine Bleeding in Nineveh Province

Alnuaimy¹,

Al-Allaf²,

Al-Omar³

2021

Ann Coll Med Mosul

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“…Also, there was a significantly higher Ki-67 expression in grade1 endometrial carcinoma cases (76.5%) than that of atypical endometrial hyperplasia cases (30%). This finding was in coincidence with that of Shalini et al, (2019) who found that there was a significant positive relationship between Ki-67 expression in endometrial hyperplasia and endometrial carcinoma. So, the Ki-67 labelling index could be used in differentiation between endometrial hyperplasia with atypia and grade 1 endometrial carcinoma.…”

Section: Discussionsupporting

confidence: 84%

OCT4, Ki-67 and VEGF as Prognostic Factors in Endometrial Carcinoma and Their Role in The Differentiation between Atypical Endometrial Hyperplasia and Grade 1 Endometrial Carcinoma: an Immunohistochemical study

El‐Anwar

Amer

2021

International Journal of Cancer and Biomedical Research

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It is with great pleasure that I write this editorial to welcome you to the IJCBR. This journal provides a platform for publication of original and reviews research articles, short communications, letter to editor, thesis abstract, conference report, and case studies. These types of publication are directed at the interface of the fields of cancer and biomedical research.The IJCBR relies on a distinguished expert of the Advisory and Editorial Board Members from the top international league covering in depth the related topics. They timely review all manuscripts and maintain highest standards of quality and scientific methodology and ethical concepts. Meanwhile, we take all possible means to keep the time of the publication process as short as possible.I take this chance to welcome your contributions to the IJCBR and have every expectation that it will soon become one of the most respected journals in both the fields of cancer and biomedical research.

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Ki-67 Expression in Endometrial Hyperplasia

Cited by 2 publications

References 0 publications

Clarification of Ki67 Expression in Association with the Histological Picture of Endometrium in Cases with Abnormal Uterine Bleeding in Nineveh Province

Clarification of Ki67 Expression in Association with the Histological Picture of Endometrium in Cases with Abnormal Uterine Bleeding in Nineveh Province

OCT4, Ki-67 and VEGF as Prognostic Factors in Endometrial Carcinoma and Their Role in The Differentiation between Atypical Endometrial Hyperplasia and Grade 1 Endometrial Carcinoma: an Immunohistochemical study

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